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• W2884295246 abstract "In the era of precision medicine, the prediction of ovarian function recovery from chemotherapy-induced amenorrhoea using feasible biological markers may be helpful to optimise the treatment strategy for young patients with hormone receptor-positive breast cancer. The purpose of this study was to investigate the accuracy of post-chemotherapy biological markers for predicting the recovery of ovarian function in breast cancer patients of the ASTRRA trial, with chemotherapy-induced amenorrhoea. Using data of 82 participants from a single institution in the ASTRRA trial, the post-chemotherapy serum levels of the anti-Müllerian hormone (AMH), oestradiol, inhibin B and other clinical factors associated with chemotherapy-induced amenorrhoea were evaluated. Recovery of ovarian function was defined by the resumption of menstruation manifested by vaginal bleeding. Fifty-two patients regained menstruation within 55 months after enrolment. In univariate analysis, <40 years of age ( P = 0.009), oestradiol ≥37 pg/mL ( P = 0.003) or AMH ≥800 pg/mL ( P = 0.026) were associated with recovery of menstruation. On multivariate analysis, oestradiol (hazard ratio: 3.171, 95% CI: 1.306–7.699, P = 0.011) and AMH (hazard ratio: 2.853, 95% CI: 1.011–8.046, P = 0.048) remained as significant independent predictors for resumption of menstruation. The diagnostic accuracy of age, oestradiol and AMH in predicting the resumption of menstruation was 38.3, 23.3 and 86.7%, respectively. In conclusion, post-chemotherapy AMH level might be a relatively accurate predictor of the recovery of ovarian function, presented by resumption of menstruation in breast cancer patients with chemotherapy-induced amenorrhoea." @default.
• W2884295246 created "2018-08-03" @default.
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• W2884295246 date "2018-08-01" @default.
• W2884295246 modified "2023-10-18" @default.
• W2884295246 title "Post-chemotherapy serum anti-Müllerian hormone level predicts ovarian function recovery" @default.
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• W2884295246 doi "https://doi.org/10.1530/ec-18-0180" @default.
• W2884295246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6144937" @default.
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