Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884308191> ?p ?o ?g. }
- W2884308191 endingPage "301" @default.
- W2884308191 startingPage "279" @default.
- W2884308191 abstract "The pathological phenomenon of somatopause, noticeable in hypogonadal ageing subjects, is based on the growth hormone (GH) production and secretion decrease along with the fall in GH binding protein and insulin-like growth factor 1 (IGF-1) levels, causing different musculoskeletal, metabolic and mental issues. From the perspective of safety and efficacy, GH treatment is considered to be highly controversial, while some other therapeutic approaches (application of IGF-1, GH secretagogues, gonadal steroids, cholinesterase-inhibitors or various combinations) exhibit more or less pronounced weaknesses in this respect. Soy isoflavones, phytochemicals that have already demonstrated the health benefits in treated elderly, at least experimentally reveal their potential for the somatopausal symptoms remediation. Namely, genistein enhanced GHRH-stimulated cAMP accumulation and GH release in rat anterior pituitary cells; refreshed and stimulated the somatotropic system (hypothalamic nuclei and pituitary GH cells) function in a rat model of the mild andropause, and stimulated the GH output in ovariectomized ewes as well as the amplitude of GH pulses in the rams. Daidzein, on the other hand, increased body mass, trabecular bone mass and decreased bone turnover in the animal model of severe andropause, while both isoflavones demonstrated blood cholesterol-lowering effect in the same model. These data, which necessarily need to be preclinically and clinically filtered, hint some cautious optimism and call for further innovative designing of balanced soy isoflavone-based therapeutics." @default.
- W2884308191 created "2018-08-03" @default.
- W2884308191 creator A5001563380 @default.
- W2884308191 creator A5006257248 @default.
- W2884308191 creator A5023683886 @default.
- W2884308191 creator A5026062513 @default.
- W2884308191 creator A5039575336 @default.
- W2884308191 creator A5051947980 @default.
- W2884308191 creator A5056665434 @default.
- W2884308191 creator A5076097439 @default.
- W2884308191 creator A5083446466 @default.
- W2884308191 date "2018-01-01" @default.
- W2884308191 modified "2023-09-23" @default.
- W2884308191 title "Somatopause, weaknesses of the therapeutic approaches and the cautious optimism based on experimental ageing studies with soy isoflavones." @default.
- W2884308191 cites W100498014 @default.
- W2884308191 cites W1023966312 @default.
- W2884308191 cites W1553456894 @default.
- W2884308191 cites W1564169413 @default.
- W2884308191 cites W1656644300 @default.
- W2884308191 cites W1850592943 @default.
- W2884308191 cites W1895814136 @default.
- W2884308191 cites W191093306 @default.
- W2884308191 cites W1939905704 @default.
- W2884308191 cites W194212139 @default.
- W2884308191 cites W1963672621 @default.
- W2884308191 cites W1963876620 @default.
- W2884308191 cites W1966090958 @default.
- W2884308191 cites W1966470614 @default.
- W2884308191 cites W1966537913 @default.
- W2884308191 cites W1967083598 @default.
- W2884308191 cites W1971860231 @default.
- W2884308191 cites W1972517743 @default.
- W2884308191 cites W1974148190 @default.
- W2884308191 cites W1976853911 @default.
- W2884308191 cites W1978137874 @default.
- W2884308191 cites W1979535902 @default.
- W2884308191 cites W1979939179 @default.
- W2884308191 cites W1980766143 @default.
- W2884308191 cites W1988513299 @default.
- W2884308191 cites W1989517150 @default.
- W2884308191 cites W1990435889 @default.
- W2884308191 cites W1994843056 @default.
- W2884308191 cites W1994903876 @default.
- W2884308191 cites W1995739512 @default.
- W2884308191 cites W1996288386 @default.
- W2884308191 cites W1996905895 @default.
- W2884308191 cites W2002748611 @default.
- W2884308191 cites W2003868618 @default.
- W2884308191 cites W2006708516 @default.
- W2884308191 cites W2008210901 @default.
- W2884308191 cites W2008687666 @default.
- W2884308191 cites W2020099117 @default.
- W2884308191 cites W2020525292 @default.
- W2884308191 cites W2021549266 @default.
- W2884308191 cites W2021805888 @default.
- W2884308191 cites W2025308095 @default.
- W2884308191 cites W2025454481 @default.
- W2884308191 cites W2025558014 @default.
- W2884308191 cites W2028137086 @default.
- W2884308191 cites W2029468511 @default.
- W2884308191 cites W2029978377 @default.
- W2884308191 cites W2030684674 @default.
- W2884308191 cites W2031098338 @default.
- W2884308191 cites W2034870004 @default.
- W2884308191 cites W2038435910 @default.
- W2884308191 cites W2038622831 @default.
- W2884308191 cites W2042134024 @default.
- W2884308191 cites W2044351326 @default.
- W2884308191 cites W2044797618 @default.
- W2884308191 cites W2047433850 @default.
- W2884308191 cites W2054299085 @default.
- W2884308191 cites W2055720658 @default.
- W2884308191 cites W2057085338 @default.
- W2884308191 cites W2058626751 @default.
- W2884308191 cites W2059113657 @default.
- W2884308191 cites W2062369866 @default.
- W2884308191 cites W2062782039 @default.
- W2884308191 cites W2063701256 @default.
- W2884308191 cites W2064356721 @default.
- W2884308191 cites W2064557280 @default.
- W2884308191 cites W2064634599 @default.
- W2884308191 cites W2066151347 @default.
- W2884308191 cites W2066519654 @default.
- W2884308191 cites W2072099001 @default.
- W2884308191 cites W2073031659 @default.
- W2884308191 cites W2074239119 @default.
- W2884308191 cites W2074943467 @default.
- W2884308191 cites W2076489992 @default.
- W2884308191 cites W2078801161 @default.
- W2884308191 cites W2081692073 @default.
- W2884308191 cites W2081975982 @default.
- W2884308191 cites W2082850458 @default.
- W2884308191 cites W2084412587 @default.
- W2884308191 cites W2087672051 @default.
- W2884308191 cites W2088207247 @default.
- W2884308191 cites W2089530774 @default.
- W2884308191 cites W2089845502 @default.
- W2884308191 cites W2090540664 @default.