FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884317587> ?p ?o ?g. }

• W2884317587 endingPage "1006" @default.
• W2884317587 startingPage "999" @default.
• W2884317587 abstract "Abstract Understanding how tumor cells fundamentally alter their identity is critical to identify specific vulnerabilities for use in precision medicine. In B-cell malignancy, knowledge of genetic changes has resulted in great gains in our understanding of the biology of tumor cells, impacting diagnosis, prognosis, and treatment. Despite this knowledge, much remains to be explained as genetic events do not completely explain clinical behavior and outcomes. Many patients lack recurrent driver mutations, and said drivers can persist in nonmalignant cells of healthy individuals remaining cancer-free for decades. Epigenetics has emerged as a valuable avenue to further explain tumor phenotypes. The epigenetic landscape is the software that powers and stabilizes cellular identity by abridging a broad genome into the essential information required per cell. A genome-level view of B-cell malignancies reveals complex but recurrent epigenetic patterns that define tumor types and subtypes, permitting high-resolution classification and novel insight into tumor-specific mechanisms. Epigenetic alterations are guided by distinct cellular processes, such as polycomb-based silencing, transcription, signaling pathways, and transcription factor activity, and involve B-cell-specific aspects, such as activation-induced cytidine deaminase activity and germinal center–specific events. Armed with a detailed knowledge of the epigenetic events that occur across the spectrum of B-cell differentiation, B-cell tumor–specific aberrations can be detected with improved accuracy and serve as a model for identification of tumor-specific events in cancer. Insight gained through recent efforts may prove valuable in guiding the use of both epigenetic- and nonepigenetic-based therapies." @default.
• W2884317587 created "2018-08-03" @default.
• W2884317587 creator A5044008222 @default.
• W2884317587 creator A5089967077 @default.
• W2884317587 date "2018-09-06" @default.
• W2884317587 modified "2023-10-17" @default.
• W2884317587 title "Insight into origins, mechanisms, and utility of DNA methylation in B-cell malignancies" @default.
• W2884317587 cites W1255676896 @default.
• W2884317587 cites W1504303645 @default.
• W2884317587 cites W1549870670 @default.
• W2884317587 cites W1571666545 @default.
• W2884317587 cites W1878239255 @default.
• W2884317587 cites W1907569406 @default.
• W2884317587 cites W1967224500 @default.
• W2884317587 cites W1968931043 @default.
• W2884317587 cites W1969334905 @default.
• W2884317587 cites W1969670934 @default.
• W2884317587 cites W1973946419 @default.
• W2884317587 cites W1975272871 @default.
• W2884317587 cites W1984046622 @default.
• W2884317587 cites W1984562049 @default.
• W2884317587 cites W1986560938 @default.
• W2884317587 cites W1990986028 @default.
• W2884317587 cites W1991017737 @default.
• W2884317587 cites W2003455246 @default.
• W2884317587 cites W2006795991 @default.
• W2884317587 cites W2011730338 @default.
• W2884317587 cites W2011988545 @default.
• W2884317587 cites W2014203515 @default.
• W2884317587 cites W2015845481 @default.
• W2884317587 cites W2017202925 @default.
• W2884317587 cites W2019655196 @default.
• W2884317587 cites W2020658841 @default.
• W2884317587 cites W2027544745 @default.
• W2884317587 cites W2029742174 @default.
• W2884317587 cites W2031192472 @default.
• W2884317587 cites W2031925819 @default.
• W2884317587 cites W2035419765 @default.
• W2884317587 cites W2042087070 @default.
• W2884317587 cites W2044627735 @default.
• W2884317587 cites W2046623240 @default.
• W2884317587 cites W2055986128 @default.
• W2884317587 cites W2056677678 @default.
• W2884317587 cites W2060822327 @default.
• W2884317587 cites W2071549499 @default.
• W2884317587 cites W2076154138 @default.
• W2884317587 cites W2079302244 @default.
• W2884317587 cites W2086323499 @default.
• W2884317587 cites W2087366831 @default.
• W2884317587 cites W2087785865 @default.
• W2884317587 cites W2088580309 @default.
• W2884317587 cites W2092116145 @default.
• W2884317587 cites W2098958008 @default.
• W2884317587 cites W2101491950 @default.
• W2884317587 cites W2117792884 @default.
• W2884317587 cites W2123032740 @default.
• W2884317587 cites W2125154191 @default.
• W2884317587 cites W2127305605 @default.
• W2884317587 cites W2128919238 @default.
• W2884317587 cites W2131314720 @default.
• W2884317587 cites W2131793839 @default.
• W2884317587 cites W2134811927 @default.
• W2884317587 cites W2136784327 @default.
• W2884317587 cites W2137147070 @default.
• W2884317587 cites W2141125218 @default.
• W2884317587 cites W2141869972 @default.
• W2884317587 cites W2152807349 @default.
• W2884317587 cites W2163327652 @default.
• W2884317587 cites W2164327622 @default.
• W2884317587 cites W2170210082 @default.
• W2884317587 cites W2173885591 @default.
• W2884317587 cites W2200034306 @default.
• W2884317587 cites W2275847773 @default.
• W2884317587 cites W2284954245 @default.
• W2884317587 cites W2408036343 @default.
• W2884317587 cites W2488297479 @default.
• W2884317587 cites W2514915762 @default.
• W2884317587 cites W2553488063 @default.
• W2884317587 cites W2587989857 @default.
• W2884317587 cites W2589386142 @default.
• W2884317587 cites W2605327281 @default.
• W2884317587 cites W2617540636 @default.
• W2884317587 cites W2748203881 @default.
• W2884317587 cites W2783139678 @default.
• W2884317587 cites W2795164082 @default.
• W2884317587 cites W2804868427 @default.
• W2884317587 cites W3023120669 @default.
• W2884317587 cites W4213257593 @default.
• W2884317587 cites W4244151789 @default.
• W2884317587 cites W4376999543 @default.
• W2884317587 doi "https://doi.org/10.1182/blood-2018-02-692970" @default.
• W2884317587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30037886" @default.
• W2884317587 hasPublicationYear "2018" @default.
• W2884317587 type Work @default.
• W2884317587 sameAs 2884317587 @default.
• W2884317587 citedByCount "22" @default.
• W2884317587 countsByYear W28843175872018 @default.
• W2884317587 countsByYear W28843175872019 @default.

• next