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• W2884341880 startingPage "9781" @default.
• W2884341880 abstract "Deoxyribonucleic acid (DNA) has been used as a material for a variety of applications, including surface functionalization for cell biological or in vitro reconstitution studies. Use of DNA-based surface functionalization eliminates limitations of multiplexing posed by traditionally used methods in applications requiring spatially segregated surface functionalization. Recently, we have reported a stochastic, membrane fusion-based strategy to fabricate multicomponent membrane array substrates displaying spatially segregated protein ligands using biotin–streptavidin and Ni-NTA–polyhistidine interactions. Here, we report the delivery of DNA oligonucleotide-conjugated lipid molecules to membrane corrals, allowing spatially segregated membrane corral functionalization in a membrane microarray. Incubation of microbeads coated with the supported membrane resulted in an exchange of lipid contents with planar membrane corrals present on a micropatterned substrate. Increases in the system temperature and membrane corral size resulted in alterations in the rate constant of lipid exchange, which are in agreement with our previously developed analytical model and further confirm that lipid exchange is a diffusion-based process that takes place after the formation of a long “fusion-stalk” between the two membranes. We take advantage of the physical dimensions of the fusion-stalk with a large aspect ratio to deliver DNA oligonucleotide-conjugated lipid molecules to membrane corrals. We believe that the ability to functionalize membrane corrals with DNA oligonucleotides significantly increases the utility of the stochastic fusion-mediated lipid delivery strategy in the functionalization of biomolecules such as DNA or DNA-conjugated protein ligands." @default.
• W2884341880 created "2018-08-03" @default.
• W2884341880 creator A5011860224 @default.
• W2884341880 creator A5050023964 @default.
• W2884341880 creator A5066515999 @default.
• W2884341880 date "2018-07-23" @default.
• W2884341880 modified "2023-10-17" @default.
• W2884341880 title "Fabrication of Multicomponent, Spatially Segregated DNA and Protein-Functionalized Supported Membrane Microarray" @default.
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• W2884341880 doi "https://doi.org/10.1021/acs.langmuir.8b01364" @default.
• W2884341880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30032610" @default.
• W2884341880 hasPublicationYear "2018" @default.
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