FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884385219> ?p ?o ?g. }

• W2884385219 abstract "Proper migration and invasion of trophoblast cells into endometrium is vital for successful embryo implantation during early pregnancy. Benzo[a]pyrene-7, 8-diol-9, 10-epoxide (BPDE) is an ultimate carcinogenic product of benzo[a]pyrene (BaP), which causes multiple trophoblast-related diseases. However, the mechanism of BPDE-inhibited migration/invasion of trophoblast cells is still unclear. In this work, we found that BPDE significantly inhibited the filopodia formation and migration/invasion of human trophoblast Swan 71 cells. BPDE up-regulated the level of miR-194-3p, which further inhibited the phosphoinositide 3-kinase (PI3K)/AKT/ cell division cycle 42/ p21 (RAC1) activated kinase 1 signaling pathway and depressed the filophdia formation of Swan71 cells. Addition of 740 Y-P, the activator of phosphoinositide 3-kinase, could stimulate cell migration/invasion, confirming the involvement of this pathway. Knock-down of miR-194-3p up-regulated this pathway and promoted filopodia formation and migration/invasion. Conversely, overexpression of miR-194-3p down-regulated this pathway and inhibited cell migration/invasion. Therefore, miR-194-3p takes important roles in the BPDE-inhibited filopodia formation and cell migration/invasion, providing valuable information in the BPDE-induced dysfunctions of human extravillous trophoblast cells." @default.
• W2884385219 created "2018-08-03" @default.
• W2884385219 creator A5001211136 @default.
• W2884385219 creator A5004483141 @default.
• W2884385219 creator A5007006789 @default.
• W2884385219 creator A5011534683 @default.
• W2884385219 creator A5041588764 @default.
• W2884385219 creator A5050000861 @default.
• W2884385219 creator A5070538645 @default.
• W2884385219 creator A5078217728 @default.
• W2884385219 creator A5085322583 @default.
• W2884385219 date "2018-07-16" @default.
• W2884385219 modified "2023-10-16" @default.
• W2884385219 title "Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast Swan 71 cells due to the inhibited filopodia formation and down-regulated PI3K/AKT/CDC42/PAK1 pathway mediated by the increased miR-194-3p" @default.
• W2884385219 cites W1204907234 @default.
• W2884385219 cites W1228554575 @default.
• W2884385219 cites W14098964 @default.
• W2884385219 cites W1534883357 @default.
• W2884385219 cites W169992884 @default.
• W2884385219 cites W1907523206 @default.
• W2884385219 cites W1968719918 @default.
• W2884385219 cites W1989374522 @default.
• W2884385219 cites W1998604466 @default.
• W2884385219 cites W2006292913 @default.
• W2884385219 cites W2011756230 @default.
• W2884385219 cites W2013717277 @default.
• W2884385219 cites W2017291633 @default.
• W2884385219 cites W2023656180 @default.
• W2884385219 cites W2027623923 @default.
• W2884385219 cites W2038520092 @default.
• W2884385219 cites W2040153845 @default.
• W2884385219 cites W2043182261 @default.
• W2884385219 cites W2059533825 @default.
• W2884385219 cites W2067677546 @default.
• W2884385219 cites W2068496842 @default.
• W2884385219 cites W2070397931 @default.
• W2884385219 cites W2079260294 @default.
• W2884385219 cites W2080360745 @default.
• W2884385219 cites W2082905388 @default.
• W2884385219 cites W2083605403 @default.
• W2884385219 cites W2087966784 @default.
• W2884385219 cites W2090801178 @default.
• W2884385219 cites W2103002807 @default.
• W2884385219 cites W2122167615 @default.
• W2884385219 cites W2123508838 @default.
• W2884385219 cites W2129277563 @default.
• W2884385219 cites W2136612732 @default.
• W2884385219 cites W2142184585 @default.
• W2884385219 cites W2145923695 @default.
• W2884385219 cites W2171553175 @default.
• W2884385219 cites W2280978409 @default.
• W2884385219 cites W2328145836 @default.
• W2884385219 cites W2328524037 @default.
• W2884385219 cites W2352815694 @default.
• W2884385219 cites W2418449526 @default.
• W2884385219 cites W2461096438 @default.
• W2884385219 cites W2464767256 @default.
• W2884385219 cites W2567353769 @default.
• W2884385219 cites W2586440237 @default.
• W2884385219 cites W2594340041 @default.
• W2884385219 cites W2599709405 @default.
• W2884385219 cites W2606991993 @default.
• W2884385219 cites W2616030410 @default.
• W2884385219 cites W2781734491 @default.
• W2884385219 cites W2783952484 @default.
• W2884385219 doi "https://doi.org/10.1093/toxsci/kfy182" @default.
• W2884385219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30011042" @default.
• W2884385219 hasPublicationYear "2018" @default.
• W2884385219 type Work @default.
• W2884385219 sameAs 2884385219 @default.
• W2884385219 citedByCount "6" @default.
• W2884385219 countsByYear W28843852192019 @default.
• W2884385219 countsByYear W28843852192020 @default.
• W2884385219 countsByYear W28843852192021 @default.
• W2884385219 countsByYear W28843852192022 @default.
• W2884385219 crossrefType "journal-article" @default.
• W2884385219 hasAuthorship W2884385219A5001211136 @default.
• W2884385219 hasAuthorship W2884385219A5004483141 @default.
• W2884385219 hasAuthorship W2884385219A5007006789 @default.
• W2884385219 hasAuthorship W2884385219A5011534683 @default.
• W2884385219 hasAuthorship W2884385219A5041588764 @default.
• W2884385219 hasAuthorship W2884385219A5050000861 @default.
• W2884385219 hasAuthorship W2884385219A5070538645 @default.
• W2884385219 hasAuthorship W2884385219A5078217728 @default.
• W2884385219 hasAuthorship W2884385219A5085322583 @default.
• W2884385219 hasBestOaLocation W28843852191 @default.
• W2884385219 hasConcept C125705527 @default.
• W2884385219 hasConcept C137738243 @default.
• W2884385219 hasConcept C1491633281 @default.
• W2884385219 hasConcept C172680121 @default.
• W2884385219 hasConcept C185592680 @default.
• W2884385219 hasConcept C2776953305 @default.
• W2884385219 hasConcept C2777495146 @default.
• W2884385219 hasConcept C2779234561 @default.
• W2884385219 hasConcept C54355233 @default.
• W2884385219 hasConcept C55493867 @default.
• W2884385219 hasConcept C62478195 @default.
• W2884385219 hasConcept C75217442 @default.
• W2884385219 hasConcept C86554907 @default.
• W2884385219 hasConcept C86803240 @default.

• next