Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884393381> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2884393381 endingPage "50.3" @default.
- W2884393381 startingPage "50.3" @default.
- W2884393381 abstract "Abstract Type-I Interferons (IFN-I), which are innate immune cytokines with broad-spectrum antiviral effects, are regulated by the host Ubiquitin (Ub) system. Evidence has shown that new forms of poly-Ub chains, which are not covalently attached to any protein (termed unanchored poly-Ub), are important activators of kinase activity in vitro. We recently reported that unanchored K48-linked poly-Ub synthesized by the E3-Ub ligase TRIM6 promote IFN-mediated antiviral innate immunity in vivo by activating the IKKɛ kinase. Intriguingly, we found that two different highly pathogenic viruses, Nipah (NiV; Paramyxoviridae family) and Ebola (EBOV; Filoviridae family), hijack TRIM6 to promote virus replication through mechanisms that involve both covalent and unanchored Ub. This indicates that host antiviral factors can have direct pro-viral functions. We also found that Zika virus (ZIKV; Flaviviridae family), which can cause congenital microcephaly in newborns, requires ubiquitination of viral proteins for efficient replication. Importantly, ZIKV ubiquitination occurs in vivo in a tissue-specific manner. Recombinant infectious ZIKV mutants that lack ubiquitination on specific sites are attenuated in mice and appear to differentially replicate in tissues. As compared to other flaviviruses, ZIKV acquired an additional ubiquitination site, which may be responsible for providing ZIKV an advantage to replicate in brain and reproductive tissue. This would be the first example of a flavivirus utilizing the Ub system for tissue tropism. Taken together, our work suggests that divergent viruses hijack similar innate immune host factors to enhance their replication. This information could help design novel broad-spectrum antiviral strategies" @default.
- W2884393381 created "2018-08-03" @default.
- W2884393381 creator A5008961608 @default.
- W2884393381 creator A5012810138 @default.
- W2884393381 creator A5019800098 @default.
- W2884393381 creator A5029224233 @default.
- W2884393381 creator A5038895852 @default.
- W2884393381 creator A5057764651 @default.
- W2884393381 creator A5070606892 @default.
- W2884393381 creator A5076149634 @default.
- W2884393381 creator A5081327494 @default.
- W2884393381 date "2018-05-01" @default.
- W2884393381 modified "2023-10-18" @default.
- W2884393381 title "The host ubiquitin system in innate immunity and virus replication: proviral and antiviral functions of the host E3-ubiquitin ligase TRIM family" @default.
- W2884393381 doi "https://doi.org/10.4049/jimmunol.200.supp.50.3" @default.
- W2884393381 hasPublicationYear "2018" @default.
- W2884393381 type Work @default.
- W2884393381 sameAs 2884393381 @default.
- W2884393381 citedByCount "1" @default.
- W2884393381 countsByYear W28843933812020 @default.
- W2884393381 crossrefType "journal-article" @default.
- W2884393381 hasAuthorship W2884393381A5008961608 @default.
- W2884393381 hasAuthorship W2884393381A5012810138 @default.
- W2884393381 hasAuthorship W2884393381A5019800098 @default.
- W2884393381 hasAuthorship W2884393381A5029224233 @default.
- W2884393381 hasAuthorship W2884393381A5038895852 @default.
- W2884393381 hasAuthorship W2884393381A5057764651 @default.
- W2884393381 hasAuthorship W2884393381A5070606892 @default.
- W2884393381 hasAuthorship W2884393381A5076149634 @default.
- W2884393381 hasAuthorship W2884393381A5081327494 @default.
- W2884393381 hasConcept C104317684 @default.
- W2884393381 hasConcept C134459356 @default.
- W2884393381 hasConcept C136449434 @default.
- W2884393381 hasConcept C137993225 @default.
- W2884393381 hasConcept C140704245 @default.
- W2884393381 hasConcept C159047783 @default.
- W2884393381 hasConcept C2522874641 @default.
- W2884393381 hasConcept C25602115 @default.
- W2884393381 hasConcept C2777053367 @default.
- W2884393381 hasConcept C2779635636 @default.
- W2884393381 hasConcept C2780568436 @default.
- W2884393381 hasConcept C54355233 @default.
- W2884393381 hasConcept C86803240 @default.
- W2884393381 hasConcept C8891405 @default.
- W2884393381 hasConceptScore W2884393381C104317684 @default.
- W2884393381 hasConceptScore W2884393381C134459356 @default.
- W2884393381 hasConceptScore W2884393381C136449434 @default.
- W2884393381 hasConceptScore W2884393381C137993225 @default.
- W2884393381 hasConceptScore W2884393381C140704245 @default.
- W2884393381 hasConceptScore W2884393381C159047783 @default.
- W2884393381 hasConceptScore W2884393381C2522874641 @default.
- W2884393381 hasConceptScore W2884393381C25602115 @default.
- W2884393381 hasConceptScore W2884393381C2777053367 @default.
- W2884393381 hasConceptScore W2884393381C2779635636 @default.
- W2884393381 hasConceptScore W2884393381C2780568436 @default.
- W2884393381 hasConceptScore W2884393381C54355233 @default.
- W2884393381 hasConceptScore W2884393381C86803240 @default.
- W2884393381 hasConceptScore W2884393381C8891405 @default.
- W2884393381 hasIssue "1_Supplement" @default.
- W2884393381 hasLocation W28843933811 @default.
- W2884393381 hasOpenAccess W2884393381 @default.
- W2884393381 hasPrimaryLocation W28843933811 @default.
- W2884393381 hasRelatedWork W2521741667 @default.
- W2884393381 hasRelatedWork W2605513659 @default.
- W2884393381 hasRelatedWork W2615109422 @default.
- W2884393381 hasRelatedWork W2791128717 @default.
- W2884393381 hasRelatedWork W2884393381 @default.
- W2884393381 hasRelatedWork W2943702971 @default.
- W2884393381 hasRelatedWork W2950929112 @default.
- W2884393381 hasRelatedWork W2951719746 @default.
- W2884393381 hasRelatedWork W2979739618 @default.
- W2884393381 hasRelatedWork W3032424987 @default.
- W2884393381 hasVolume "200" @default.
- W2884393381 isParatext "false" @default.
- W2884393381 isRetracted "false" @default.
- W2884393381 magId "2884393381" @default.
- W2884393381 workType "article" @default.