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- W2884394723 endingPage "1800141" @default.
- W2884394723 startingPage "1800141" @default.
- W2884394723 abstract "Fluoroquinolones remain one of the most important kind of antibacterial agents used nowadays. The emergence of more virulent and resistant strains of bacteria by the development of either mutated DNA-binding proteins or efflux pump mechanism for drugs is considered the main problem associated with the therapeutic use of these drugs. This situation participated in pushing researchers to design new fluoroquinolone derivatives, mainly with different substituents at C-7 to withstand these resistant strains of bacteria and to obtain a wider spectrum of activity including activity against anaerobic organisms. Conjugation of fluoroquinolones with substitutions such as 1,2,4-triazoles, alkyl oximes, flavonoids, aryl furans, benzofuroxans, metronidazoles or even other antibiotics such as neomycin-B produced derivatives that have a superior and wider spectrum of activity and better resistance than the classical fluoroquinolone agents. Addition of a hydroxamic acid moiety to fluoroquinolones also increased the activity against Proteus mirabilis, which represents one of the most resistant strains of bacteria in urinary tract infections. This review aims to highlight the recent updates made for fluoroquinolones for broadening the spectrum of activity to become active not only against resistant strains of bacteria but also against anaerobic pathogens." @default.
- W2884394723 created "2018-08-03" @default.
- W2884394723 creator A5033562597 @default.
- W2884394723 creator A5034800239 @default.
- W2884394723 creator A5044481467 @default.
- W2884394723 creator A5072393450 @default.
- W2884394723 date "2018-07-26" @default.
- W2884394723 modified "2023-10-14" @default.
- W2884394723 title "Recent updates of fluoroquinolones as antibacterial agents" @default.
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