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- W2884414521 abstract "Emerging evidence suggests that cellular metabolism plays a critical role in regulating immune activation. Alterations in energy and lipid and amino acid metabolism have been shown to contribute to type I interferon (IFN) responses in macrophages, but the relationship between metabolic reprogramming and the establishment of early antiviral function remains poorly defined. Here, we used transcriptional profiling datasets to develop global metabolic signatures associated with early IFN- α responses in two primary macrophage model systems: mouse bone marrow-derived macrophages (BMM) and human monocyte-derived macrophages (MDM). Short-term stimulation with IFN- α (<4 hours) was associated with significant metabolic rewiring, with >500 metabolic genes altered in mouse and human macrophage models. Pathway and network analysis identified alterations in genes associated with cellular bioenergetics, cellular oxidant status, cAMP/AMP and cGMP/GMP ratios, branched chain amino acid catabolism, cell membrane composition, fatty acid synthesis, and β -oxidation as key features of early IFN- α responses. These changes may have important implications for initial establishment of antiviral function in these cells." @default.
- W2884414521 created "2018-08-03" @default.
- W2884414521 creator A5005719112 @default.
- W2884414521 creator A5024683005 @default.
- W2884414521 creator A5065639469 @default.
- W2884414521 creator A5071692009 @default.
- W2884414521 creator A5073053551 @default.
- W2884414521 creator A5088839248 @default.
- W2884414521 date "2018-07-25" @default.
- W2884414521 modified "2023-10-18" @default.
- W2884414521 title "Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses" @default.
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