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- W2884441130 abstract "Background: Multi-drug resistant (MDR) pathogens are of increasing concern in clinical medicine. Patients with prosthetic joints as well as those with fractures are at risk of contracting infections. Extent and frequency of infections with MDR bacteria in patients with osteoarticular infections in Germany are largely unknown. Methods & Materials: A large case series of patients admitted to a specialized septic surgery ward in a tertiary referral center was analyzed for the presence of MDR bacteria in joint fluids, tissue samples and swabs taken from purulent secretions during surgery. Results: Patients admitted in 2014-2016 with osteoarticular infections with and without prosthetic material and positive microbiological samples were included in the analysis. In 274 individuals 554 microbiological samples were obtained which disclosed 656 pathogens. MDR bacteria were isolated in 43/656 (6.6%). The distribution of MDR pathogens comprised MRSA in 22 (3.4%) cases, VRE in 12 (1.8%), ESBL-producing Gram-negative bacteria (E. coli and K. pneumoniae) in 6 (0.9%), and non-fermenter with peculiar resistance patterns (MDR-Stenotrophomonas maltophilia, Colistin-resistant P. aeruginosa) in 3 (0.5%). Carbapenemase-producing bacteria were not retrieved. The numbers of detected MDR pathogens increased over the years (5.8% in 2014, 6.8% in 2015, and 8.3% in 2016) albeit not reaching statistical significance. Conclusion: MDR pathogens were frequently found in our large case series. Gram-positive pathogens (MRSA, VRE) are predominating the spectrum. Difficult-to-treat Gram-negative bacteria were rarely seen." @default.
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- W2884441130 date "2018-08-01" @default.
- W2884441130 modified "2023-09-25" @default.
- W2884441130 title "Frequency of multi-drug resistant (MDR) pathogens in patients with osteoarticular infections" @default.
- W2884441130 doi "https://doi.org/10.1016/j.ijid.2018.04.3780" @default.
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