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- W2884449100 abstract "On the surface of many infectious pathogens, a dense array of complex carbohydrate structures are presented. These glycans can be seen as possible targets for the body’s immune system to recognize and elicit protection against infection. However, vaccination with a sole polysaccharide antigen does not confer long-lasting protective immunity, as most carbohydrates are T-cell independent antigens. Glycoconjugate vaccines, in which the polysaccharide is covalently attached to a protein, allows for activation of the adaptive immune system and recognition of the antigen in a T-cell dependent manner. In this chapter, an overview of carbohydrate vaccinology will be discussed, with an emphasis on T-cell immunity elicited by glycoconjugate vaccines." @default.
- W2884449100 created "2018-08-03" @default.
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- W2884449100 date "2018-01-01" @default.
- W2884449100 modified "2023-09-26" @default.
- W2884449100 title "Immunological Mechanisms of Glycoconjugate Vaccines" @default.
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- W2884449100 doi "https://doi.org/10.1021/bk-2018-1290.ch003" @default.
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