Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884466767> ?p ?o ?g. }
- W2884466767 abstract "Matrix-metalloproteinases, which are overexpressed in many types of cancer, can be applied to improve the bioavailability of chemotherapeutic drugs and guide therapeutic targeting. Thus, we aimed to develop enzyme-responsive nanoparticles based on a functionalized copolymer (mPEG-Peptide-PCL), which was sensitive to matrix metalloproteinase, as smart drug vesicles for enhanced biological specificity and reduced side effects.The rate of in vitro curcumin (Cur) release from Cur-P-NPs was not markedly accelerated in weakly acidic tumor microenvironment, indicating a stable intracellular concentration and a consistent therapeutic effect. Meanwhile, P-NPs and Cur-P-NPs displayed prominent biocompatibility, biostability, and inhibition efficiency in tumor cells. In addition, Cur-P-NPs showed higher fluorescence intensity than Cur-NPs in tumor cells, implying enhanced cell permeability and targeting ability. Moreover, the internalization and intracellular transport of Cur-P-NPs were mainly via macropinocytosis. Studies of pharmacodynamics and cellular uptake in vitro and biodistribution in vivo demonstrated that Cur-P-NPs had stronger target efficiency and therapeutic effect than Cur-DMSO and Cur-NPs in tumor tissue.Results indicate that Cur-P-NPs can be employed for active targeted drug delivery in cancer treatment and other biomedical applications." @default.
- W2884466767 created "2018-08-03" @default.
- W2884466767 creator A5001590828 @default.
- W2884466767 creator A5004242661 @default.
- W2884466767 creator A5026707180 @default.
- W2884466767 creator A5040658957 @default.
- W2884466767 creator A5052478015 @default.
- W2884466767 creator A5059241296 @default.
- W2884466767 creator A5065827229 @default.
- W2884466767 date "2018-07-16" @default.
- W2884466767 modified "2023-10-12" @default.
- W2884466767 title "PEGylated self-assembled enzyme-responsive nanoparticles for effective targeted therapy against lung tumors" @default.
- W2884466767 cites W1848342177 @default.
- W2884466767 cites W1965077945 @default.
- W2884466767 cites W1972179974 @default.
- W2884466767 cites W1973994764 @default.
- W2884466767 cites W1977290655 @default.
- W2884466767 cites W1989664813 @default.
- W2884466767 cites W1991327193 @default.
- W2884466767 cites W1995179792 @default.
- W2884466767 cites W2013205981 @default.
- W2884466767 cites W2023680279 @default.
- W2884466767 cites W2032760352 @default.
- W2884466767 cites W2043774753 @default.
- W2884466767 cites W2077166822 @default.
- W2884466767 cites W2085296436 @default.
- W2884466767 cites W2117786997 @default.
- W2884466767 cites W2132732108 @default.
- W2884466767 cites W2132949349 @default.
- W2884466767 cites W2144843667 @default.
- W2884466767 cites W2159497037 @default.
- W2884466767 cites W2235523093 @default.
- W2884466767 cites W2326797829 @default.
- W2884466767 cites W2332773279 @default.
- W2884466767 cites W2413184812 @default.
- W2884466767 cites W2492805479 @default.
- W2884466767 cites W2510654794 @default.
- W2884466767 cites W2568140571 @default.
- W2884466767 cites W2583257650 @default.
- W2884466767 cites W2585001669 @default.
- W2884466767 cites W2585814408 @default.
- W2884466767 cites W2588524377 @default.
- W2884466767 cites W2593229991 @default.
- W2884466767 cites W2604941614 @default.
- W2884466767 cites W2611363212 @default.
- W2884466767 cites W2617486555 @default.
- W2884466767 cites W2917837889 @default.
- W2884466767 doi "https://doi.org/10.1186/s12951-018-0384-8" @default.
- W2884466767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6048871" @default.
- W2884466767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30012166" @default.
- W2884466767 hasPublicationYear "2018" @default.
- W2884466767 type Work @default.
- W2884466767 sameAs 2884466767 @default.
- W2884466767 citedByCount "24" @default.
- W2884466767 countsByYear W28844667672019 @default.
- W2884466767 countsByYear W28844667672020 @default.
- W2884466767 countsByYear W28844667672021 @default.
- W2884466767 countsByYear W28844667672022 @default.
- W2884466767 countsByYear W28844667672023 @default.
- W2884466767 crossrefType "journal-article" @default.
- W2884466767 hasAuthorship W2884466767A5001590828 @default.
- W2884466767 hasAuthorship W2884466767A5004242661 @default.
- W2884466767 hasAuthorship W2884466767A5026707180 @default.
- W2884466767 hasAuthorship W2884466767A5040658957 @default.
- W2884466767 hasAuthorship W2884466767A5052478015 @default.
- W2884466767 hasAuthorship W2884466767A5059241296 @default.
- W2884466767 hasAuthorship W2884466767A5065827229 @default.
- W2884466767 hasBestOaLocation W28844667671 @default.
- W2884466767 hasConcept C109523444 @default.
- W2884466767 hasConcept C12554922 @default.
- W2884466767 hasConcept C126511603 @default.
- W2884466767 hasConcept C139770010 @default.
- W2884466767 hasConcept C141071460 @default.
- W2884466767 hasConcept C1491633281 @default.
- W2884466767 hasConcept C150903083 @default.
- W2884466767 hasConcept C178790620 @default.
- W2884466767 hasConcept C185592680 @default.
- W2884466767 hasConcept C202751555 @default.
- W2884466767 hasConcept C207001950 @default.
- W2884466767 hasConcept C2776107976 @default.
- W2884466767 hasConcept C2776694085 @default.
- W2884466767 hasConcept C2777230088 @default.
- W2884466767 hasConcept C2777807558 @default.
- W2884466767 hasConcept C2778250585 @default.
- W2884466767 hasConcept C2779820397 @default.
- W2884466767 hasConcept C2781303535 @default.
- W2884466767 hasConcept C3020616263 @default.
- W2884466767 hasConcept C502942594 @default.
- W2884466767 hasConcept C55493867 @default.
- W2884466767 hasConcept C71924100 @default.
- W2884466767 hasConcept C79879829 @default.
- W2884466767 hasConcept C86803240 @default.
- W2884466767 hasConcept C98274493 @default.
- W2884466767 hasConceptScore W2884466767C109523444 @default.
- W2884466767 hasConceptScore W2884466767C12554922 @default.
- W2884466767 hasConceptScore W2884466767C126511603 @default.
- W2884466767 hasConceptScore W2884466767C139770010 @default.
- W2884466767 hasConceptScore W2884466767C141071460 @default.
- W2884466767 hasConceptScore W2884466767C1491633281 @default.
- W2884466767 hasConceptScore W2884466767C150903083 @default.