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- W2884469415 abstract "It is often assumed that a hydrophobic drug will be entrapped in the hydrophobic environment of a micelle. Little attention is usually drawn to the actual location of the drug and the effect of the drug on properties. In this publication, we show how the chosen drug curcumin is not only unexpectedly located in the shell of the micelle but also that the accumulation in the hydrophilic block can lead to changes in morphology during self-assembly. A block copolymer poly(1-O-methacryloyl-β-d-fructopyranose)-b-poly(methyl methacrylate), poly(1-O-MAFru)36-b-PMMA192, was loaded with different amounts of curcumin. The resulting self-assembled nanoparticles were analyzed using transmission electron microscopy, small-angle X-ray scattering (SAXS), and small-angle neutron scattering (SANS). Initial microscopy evidence revealed that the presence of the drug induces morphology changes from cylindrical micelles (no drug) to polymersomes, which decreased in size with increasing amount of drug. SAXS and SANS analysis, supported by fluorescence studies, revealed that the drug is interacting with the glycopolymer block. The drug influenced not only the shape of the drug carrier but also the level of hydration of the shell. Increasing the amount of drug dehydrated the nanoparticle shell, which coincided with a lower nanoparticle uptake by MCF-7 breast cancer cells and noncancerous RAW 264.7 cells. As a result, we showed that the drug can influence the behavior of the nanoparticle in terms of shape and shell hydration, which could influence the performance in a biological setting. Although the depicted scenario may not apply to every drug carrier, it is worth evaluation if the drug will interfere in unexpected ways." @default.
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- W2884469415 date "2018-07-16" @default.
- W2884469415 modified "2023-10-16" @default.
- W2884469415 title "Drug-Induced Morphology Transition of Self-Assembled Glycopolymers: Insight into the Drug–Polymer Interaction" @default.
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- W2884469415 doi "https://doi.org/10.1021/acs.chemmater.8b01882" @default.
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