Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884480312> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2884480312 abstract "Elevated brain myo‐inositol (m‐Ins) concentration (a putative marker of neuroinflammation) has been reported in patients suffering from type 2 diabetes mellitus (T2DM). Obesity alone and T2DM have been found to be associated with a lower concentration of N‐acetyloaspartate and N‐acetylaspartylglutamate (tNAA, a marker of neuronal integrity, reflecting neuronal loss or metabolic derangement). It is not clear if these changes reverse with weight loss. The intra‐gastric balloon (IGB) is an endoscopic bariatric therapy that leads to massive weight loss and improvement of glycemic control. In this study we evaluated if tNAA/tCr and m‐Ins/tCr metabolite ratios are affected by weight loss, where tCr is the signal of creatine containing compounds. Twenty‐three morbidly obese patients, 12 of them with T2DM (OD) and 11 without T2DM (OB), as well as 11 healthy controls of normal weight (CON), underwent single voxel spectroscopy at 3 T. Spectra were obtained within a region in the left parietal white matter one month before IGB insertion, three months after IGB insertion, and one month after IGB removal. Before IGB insertion, m‐Ins/tCr was 15% higher in OD than in OB ( p = 0.005) and 12% higher in OD than in CON ( p = 0.03). m‐Ins/tCr decreased significantly by 8% over the first three months after IGB insertion ( p = 0.01) and remained normal after IGB removal. tNAA/tCr was normal in all groups throughout the study, pointing to normal brain metabolism. Normalization of m‐Ins/tCr is consistent with remission of neuroinflammation in patients with T2DM. An evaluation of long‐term effects of IGB treatment is necessary." @default.
- W2884480312 created "2018-08-03" @default.
- W2884480312 creator A5016753773 @default.
- W2884480312 creator A5023092729 @default.
- W2884480312 creator A5027587347 @default.
- W2884480312 creator A5029089999 @default.
- W2884480312 creator A5032910478 @default.
- W2884480312 creator A5042968272 @default.
- W2884480312 creator A5058438054 @default.
- W2884480312 creator A5059435980 @default.
- W2884480312 date "2018-07-16" @default.
- W2884480312 modified "2023-10-16" @default.
- W2884480312 title "Intragastric balloon therapy leads to normalization of brain magnetic resonance spectroscopic markers of diabetes in morbidly obese patients" @default.
- W2884480312 cites W1241013975 @default.
- W2884480312 cites W1730237872 @default.
- W2884480312 cites W1827986439 @default.
- W2884480312 cites W1984842633 @default.
- W2884480312 cites W1985884903 @default.
- W2884480312 cites W1995987678 @default.
- W2884480312 cites W2009214062 @default.
- W2884480312 cites W2017522259 @default.
- W2884480312 cites W2019886911 @default.
- W2884480312 cites W2039383985 @default.
- W2884480312 cites W2051344348 @default.
- W2884480312 cites W2059320693 @default.
- W2884480312 cites W2095348888 @default.
- W2884480312 cites W2102118295 @default.
- W2884480312 cites W2129304323 @default.
- W2884480312 cites W2144326540 @default.
- W2884480312 cites W2153594538 @default.
- W2884480312 cites W2154592647 @default.
- W2884480312 cites W2167996855 @default.
- W2884480312 cites W2169942790 @default.
- W2884480312 cites W2188762270 @default.
- W2884480312 cites W2291087819 @default.
- W2884480312 cites W2480854865 @default.
- W2884480312 cites W2607679012 @default.
- W2884480312 cites W2742158051 @default.
- W2884480312 cites W3211161140 @default.
- W2884480312 doi "https://doi.org/10.1002/nbm.3957" @default.
- W2884480312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30011110" @default.
- W2884480312 hasPublicationYear "2018" @default.
- W2884480312 type Work @default.
- W2884480312 sameAs 2884480312 @default.
- W2884480312 citedByCount "6" @default.
- W2884480312 countsByYear W28844803122020 @default.
- W2884480312 countsByYear W28844803122021 @default.
- W2884480312 countsByYear W28844803122023 @default.
- W2884480312 crossrefType "journal-article" @default.
- W2884480312 hasAuthorship W2884480312A5016753773 @default.
- W2884480312 hasAuthorship W2884480312A5023092729 @default.
- W2884480312 hasAuthorship W2884480312A5027587347 @default.
- W2884480312 hasAuthorship W2884480312A5029089999 @default.
- W2884480312 hasAuthorship W2884480312A5032910478 @default.
- W2884480312 hasAuthorship W2884480312A5042968272 @default.
- W2884480312 hasAuthorship W2884480312A5058438054 @default.
- W2884480312 hasAuthorship W2884480312A5059435980 @default.
- W2884480312 hasConcept C126322002 @default.
- W2884480312 hasConcept C126838900 @default.
- W2884480312 hasConcept C134018914 @default.
- W2884480312 hasConcept C143409427 @default.
- W2884480312 hasConcept C2779896295 @default.
- W2884480312 hasConcept C2781192897 @default.
- W2884480312 hasConcept C2910068830 @default.
- W2884480312 hasConcept C511355011 @default.
- W2884480312 hasConcept C544821477 @default.
- W2884480312 hasConcept C555293320 @default.
- W2884480312 hasConcept C71924100 @default.
- W2884480312 hasConceptScore W2884480312C126322002 @default.
- W2884480312 hasConceptScore W2884480312C126838900 @default.
- W2884480312 hasConceptScore W2884480312C134018914 @default.
- W2884480312 hasConceptScore W2884480312C143409427 @default.
- W2884480312 hasConceptScore W2884480312C2779896295 @default.
- W2884480312 hasConceptScore W2884480312C2781192897 @default.
- W2884480312 hasConceptScore W2884480312C2910068830 @default.
- W2884480312 hasConceptScore W2884480312C511355011 @default.
- W2884480312 hasConceptScore W2884480312C544821477 @default.
- W2884480312 hasConceptScore W2884480312C555293320 @default.
- W2884480312 hasConceptScore W2884480312C71924100 @default.
- W2884480312 hasIssue "9" @default.
- W2884480312 hasLocation W28844803121 @default.
- W2884480312 hasLocation W28844803122 @default.
- W2884480312 hasOpenAccess W2884480312 @default.
- W2884480312 hasPrimaryLocation W28844803121 @default.
- W2884480312 hasRelatedWork W1998028654 @default.
- W2884480312 hasRelatedWork W2181139296 @default.
- W2884480312 hasRelatedWork W2274316730 @default.
- W2884480312 hasRelatedWork W2331740731 @default.
- W2884480312 hasRelatedWork W2561547506 @default.
- W2884480312 hasRelatedWork W2978002788 @default.
- W2884480312 hasRelatedWork W3005123775 @default.
- W2884480312 hasRelatedWork W3008089983 @default.
- W2884480312 hasRelatedWork W3175905583 @default.
- W2884480312 hasRelatedWork W643687585 @default.
- W2884480312 hasVolume "31" @default.
- W2884480312 isParatext "false" @default.
- W2884480312 isRetracted "false" @default.
- W2884480312 magId "2884480312" @default.
- W2884480312 workType "article" @default.