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• W2884480429 abstract "Liver kinase B1 ( LKB 1 ) as a tumor suppression gene that is associated with various kinds of cancers, including lung cancer. In this study, we found that the effect of LKB 1 on tumor growth was dependent on its subcellular expression in A549 and HCC 827 cells. Full‐length LKB 1 decreased the proliferation and clonogenicity of A549‐ LKB 1 and HCC 827‐ LKB 1 cells, but increased their apoptosis. Opposite effects were observed in A549‐ LKB 1 s and HCC 827‐ LKB 1 S cells that overexpressed truncated LKB 1 without the nuclear localization sequence. The truncated cytoplasmic LKB 1 enhanced the growth of implanted tumors in vivo. The truncated cytoplasmic LKB 1 promoted autophagy, which was independent of AMP ‐activated protein kinase and mTOR signaling in A549 and HCC 827 cells. Further characterization indicated that higher levels of cytoplasmic LKB 1 expression were associated with advanced TNM stage and reduced overall survival (OS) in 190 patients with adenocarcinoma. In contrast, high nuclear expression of LKB 1 is associated with early TNM stage and longer OS . The high level of cytoplasmic LKB 1 expression was an independent risk factor for poor overall survival in patients with adenocarcinoma. Together, our results revealed that cytoplasmic LKB 1 promotes the growth of lung adenocarcinoma and could be a prognostic marker for lung adenocarcinoma." @default.
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• W2884480429 date "2018-10-01" @default.
• W2884480429 modified "2023-10-14" @default.
• W2884480429 title "Cytoplasmic liver kinase B1 promotes the growth of human lung adenocarcinoma by enhancing autophagy" @default.
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• W2884480429 doi "https://doi.org/10.1111/cas.13746" @default.
• W2884480429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172065" @default.
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