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• W2884485216 abstract "The mechanism of proton pump inhibitors (PPIs) suppressing intestinal Mg2+ uptake is unknown. The present study aimed to investigate the role of purinergic P2Y receptors in the regulation of Mg2+ absorption in normal and omeprazole-treated intestinal epithelium-like Caco-2 monolayers. Omeprazole suppressed Mg2+ transport across Caco-2 monolayers. An agonist of the P2Y2 receptor, but not the P2Y4 or P2Y6 receptor, suppressed Mg2+ transport across control and omeprazole-treated monolayers. Omeprazole enhanced P2Y2 receptor expression in Caco-2 cells. Forskolin and P2Y2 receptor agonist markedly enhanced apical HCO3- secretion by control and omeprazole-treated monolayers. The P2Y2 receptor agonist suppressed Mg2+ transport and stimulated apical HCO3- secretion through the Gq-protein coupled-phospholipase C (PLC) dependent pathway. Antagonists of cystic fibrosis transmembrane conductance regulator (CFTR) and Na+-HCO3- cotransporter-1 (NBCe1) could nullify the inhibitory effect of P2Y2 receptor agonist on Mg2+ transport across control and omeprazole-treated Caco-2 monolayers. Our results propose an inhibitory role of P2Y2 on intestinal Mg2+ absorption." @default.
• W2884485216 created "2018-08-03" @default.
• W2884485216 creator A5016386401 @default.
• W2884485216 creator A5038400877 @default.
• W2884485216 date "2018-07-21" @default.
• W2884485216 modified "2023-09-27" @default.
• W2884485216 title "The inhibitory role of purinergic P2Y receptor on Mg2+ transport across intestinal epithelium-like Caco-2 monolayer" @default.
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• W2884485216 doi "https://doi.org/10.1007/s12576-018-0628-2" @default.
• W2884485216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30032468" @default.
• W2884485216 hasPublicationYear "2018" @default.
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