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- W2884489623 abstract "Background: It seems likely that many cases of ZIKV infection were unrecognized or misdiagnosed in the past including fatal cases. Notwithstanding, having in to account that study and description of fatal cases varies among reporting countries, it is necessary to evaluate with a systematic review (SR) the casualty linkage between infection and outcome, and the clinical spectrum of ZIKV associated deaths. Methods & Materials: Eligibility criteria were: peer-reviewed articles reporting fatal cases associated with ZIKV infection. We have included English-, Spanish-, Portuguese- and French-language studies. Eligible designs: case-control, cohort studies, case reports and case series. Information published in epidemiological reports and bulletins(CDC/ECDC/WHO/PAHO) and National Governments through their surveillance systems or Health Ministries were also included. In order to assess casualty linkage between ZIKV and fatal cases a modified version of the WHO Zika Causality Working Group casualty framework was used. Protocol was registered in PROSPERO(ID:58347). Results: The research initially rendered a total of 311 articles: duplicates across the databases and articles about other viruses were eliminated. Finally, 24 articles were selected based on their relevance and pertinence of the title or abstract to the severe disease that was being evaluated, with all of them mentioning fatal outcomes. A total of 84 deaths, from 575,677 cases were obtained, for a case fatality rate (CFR) of 1.5/10,000 cases. Country with the highest CFR was Dominican Republic(32.4 deaths/10,000 cases), followed by Suriname 11.46 and Bolivia 9.72. All the deaths begun to be reported since 2015. No deaths were [globally] reported before the 2015-2016. In > 70% diagnosed used RT-PCR, in the rest MAC-ELISA. The most of the reported cases assessed temporality, and analogy as casualty dimensions, only four fully discarded other possible causes, and only two stablished a dose/response relationship between ZIKV infection and death. Conclusion: Until 2015, in general, ZIKV was not considered a dangerous pathogen, but after the first death, reported by our group in EID 2016, an increasing number of fatal cases were published. Although the pathogenicity of severe infection is poorly understood, based on in vitro and animal evidence, it is possible that antibody dependent enhancement has a role." @default.
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- W2884489623 date "2018-08-01" @default.
- W2884489623 modified "2023-10-16" @default.
- W2884489623 title "Postnatal acquired fatal Zika Virus infection in the Americas: A systematic review" @default.
- W2884489623 doi "https://doi.org/10.1016/j.ijid.2018.04.3856" @default.
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