Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884593741> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2884593741 endingPage "60" @default.
- W2884593741 startingPage "60" @default.
- W2884593741 abstract "Extracts of the Chinese plant Polygonum multiflorum (PME) are used for medicinal purposes as well as food supplement due to anti-aging effects. Despite of the common use of these food supplements, experimental data on physiological effects of PME and its underlying molecular mechanisms in vivo are limited. We used the model organism Caenorhabditis elegans to analyze anti-aging-effects of PME in vivo (life span, lipofuscin accumulation, oxidative stress resistance, thermal stress resistance) as well as the molecular signaling pathways involved. The effects of PME were examined in wildtype animals and mutants defective in the sirtuin-homologue SIR-2.1 (VC199) and the FOXO-homologue DAF-16 (CF1038). PME possesses antioxidative effects in vivo and increases oxidative stress resistance of the nematodes. While the accumulation of lipofuscin is only slightly decreased, PME causes a significant elongation (18.6%) of mean life span. DAF-16 is essential for the reduction of thermally induced ROS accumulation, while the resistance against paraquat-induced oxidative stress is dependent on SIR-2.1. For the extension of the life span, both DAF-16 and SIR-2.1 are needed. We demonstrate that PME exerts protective effects in C. elegans via modulation of distinct intracellular pathways." @default.
- W2884593741 created "2018-08-03" @default.
- W2884593741 creator A5005264712 @default.
- W2884593741 creator A5050797015 @default.
- W2884593741 creator A5060395922 @default.
- W2884593741 creator A5089407435 @default.
- W2884593741 date "2018-07-20" @default.
- W2884593741 modified "2023-09-26" @default.
- W2884593741 title "Polygonum multiflorum Extract Exerts Antioxidative Effects and Increases Life Span and Stress Resistance in the Model Organism Caenorhabditis elegans via DAF-16 and SIR-2.1" @default.
- W2884593741 cites W1485778651 @default.
- W2884593741 cites W1491571904 @default.
- W2884593741 cites W1581421889 @default.
- W2884593741 cites W1742880204 @default.
- W2884593741 cites W1897761685 @default.
- W2884593741 cites W1985779614 @default.
- W2884593741 cites W1987086384 @default.
- W2884593741 cites W1990703634 @default.
- W2884593741 cites W201251444 @default.
- W2884593741 cites W2013749723 @default.
- W2884593741 cites W2030504165 @default.
- W2884593741 cites W2071308173 @default.
- W2884593741 cites W2071898612 @default.
- W2884593741 cites W2084241292 @default.
- W2884593741 cites W2092489515 @default.
- W2884593741 cites W2132693695 @default.
- W2884593741 cites W2134979102 @default.
- W2884593741 cites W2262648582 @default.
- W2884593741 cites W2329218680 @default.
- W2884593741 cites W2460063639 @default.
- W2884593741 cites W2587676932 @default.
- W2884593741 doi "https://doi.org/10.3390/plants7030060" @default.
- W2884593741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6160924" @default.
- W2884593741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30036983" @default.
- W2884593741 hasPublicationYear "2018" @default.
- W2884593741 type Work @default.
- W2884593741 sameAs 2884593741 @default.
- W2884593741 citedByCount "13" @default.
- W2884593741 countsByYear W28845937412019 @default.
- W2884593741 countsByYear W28845937412020 @default.
- W2884593741 countsByYear W28845937412021 @default.
- W2884593741 countsByYear W28845937412022 @default.
- W2884593741 countsByYear W28845937412023 @default.
- W2884593741 crossrefType "journal-article" @default.
- W2884593741 hasAuthorship W2884593741A5005264712 @default.
- W2884593741 hasAuthorship W2884593741A5050797015 @default.
- W2884593741 hasAuthorship W2884593741A5060395922 @default.
- W2884593741 hasAuthorship W2884593741A5089407435 @default.
- W2884593741 hasBestOaLocation W28845937411 @default.
- W2884593741 hasConcept C104317684 @default.
- W2884593741 hasConcept C143065580 @default.
- W2884593741 hasConcept C185592680 @default.
- W2884593741 hasConcept C186198217 @default.
- W2884593741 hasConcept C207001950 @default.
- W2884593741 hasConcept C2776151105 @default.
- W2884593741 hasConcept C2778944004 @default.
- W2884593741 hasConcept C2780200714 @default.
- W2884593741 hasConcept C54355233 @default.
- W2884593741 hasConcept C55493867 @default.
- W2884593741 hasConcept C86803240 @default.
- W2884593741 hasConcept C95444343 @default.
- W2884593741 hasConceptScore W2884593741C104317684 @default.
- W2884593741 hasConceptScore W2884593741C143065580 @default.
- W2884593741 hasConceptScore W2884593741C185592680 @default.
- W2884593741 hasConceptScore W2884593741C186198217 @default.
- W2884593741 hasConceptScore W2884593741C207001950 @default.
- W2884593741 hasConceptScore W2884593741C2776151105 @default.
- W2884593741 hasConceptScore W2884593741C2778944004 @default.
- W2884593741 hasConceptScore W2884593741C2780200714 @default.
- W2884593741 hasConceptScore W2884593741C54355233 @default.
- W2884593741 hasConceptScore W2884593741C55493867 @default.
- W2884593741 hasConceptScore W2884593741C86803240 @default.
- W2884593741 hasConceptScore W2884593741C95444343 @default.
- W2884593741 hasIssue "3" @default.
- W2884593741 hasLocation W28845937411 @default.
- W2884593741 hasLocation W28845937412 @default.
- W2884593741 hasLocation W28845937413 @default.
- W2884593741 hasLocation W28845937414 @default.
- W2884593741 hasLocation W28845937415 @default.
- W2884593741 hasOpenAccess W2884593741 @default.
- W2884593741 hasPrimaryLocation W28845937411 @default.
- W2884593741 hasRelatedWork W1990142220 @default.
- W2884593741 hasRelatedWork W2057019541 @default.
- W2884593741 hasRelatedWork W2131651816 @default.
- W2884593741 hasRelatedWork W2376931529 @default.
- W2884593741 hasRelatedWork W2387747461 @default.
- W2884593741 hasRelatedWork W2514099511 @default.
- W2884593741 hasRelatedWork W2820098495 @default.
- W2884593741 hasRelatedWork W2899236703 @default.
- W2884593741 hasRelatedWork W3081640752 @default.
- W2884593741 hasRelatedWork W4296345034 @default.
- W2884593741 hasVolume "7" @default.
- W2884593741 isParatext "false" @default.
- W2884593741 isRetracted "false" @default.
- W2884593741 magId "2884593741" @default.
- W2884593741 workType "article" @default.