FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884594780> ?p ?o ?g. }

• W2884594780 endingPage "56" @default.
• W2884594780 startingPage "45" @default.
• W2884594780 abstract "Maladaptive behavioral outcomes following stress have been associated with immune dysregulation. For example, we have previously reported that stress-induced dorsal hippocampal interleukin-1β signaling is critical to the development of stress-enhanced fear learning (SEFL). In parallel, astroglial signaling has been linked to the development of post-traumatic stress disorder (PTSD)-like phenotypes and our most recent studies have revealed astrocytes as the predominant cellular source of stress-induced IL-1β. Here, we used chemogenetic technology and morphological analyses to further explore dorsal hippocampal astrocyte function in the context of SEFL. Using a glial-expressing DREADD construct (AAV8-GFAP-hM4Di(Gi)-mCherry), we show that dorsal hippocampal astroglial Gi activation is sufficient to attenuate SEFL. Furthermore, our data provide the first initial evidence to support the function of the glial-DREADD construct employed. Specifically, we find that CNO (clozapine-n-oxide) significantly attenuated colocalization of the Gi-coupled DREADD receptor and cyclic adenosine monophosphate (cAMP), indicating functional inhibition of cAMP production. Subsequent experiments examined dorsal hippocampal astrocyte volume, surface area, and synaptic contacts (colocalization with postsynaptic density 95 (PSD95)) following exposure to severe stress (capable of inducing SEFL). While severe stress did not alter dorsal hippocampal astrocyte volume or surface area, the severe stressor exposure reduced dorsal hippocampal PSD95 immunoreactivity and the colocalization analysis showed reduced PSD95 colocalized with astrocytes. Collectively, these data provide evidence to support the functional efficacy of the glial-expressing DREADD employed, and suggest that an astrocyte-specific manipulation, activation of astroglial Gi signaling, is sufficient to protect against the development of SEFL, a PTSD-like behavior." @default.
• W2884594780 created "2018-08-03" @default.
• W2884594780 creator A5001688558 @default.
• W2884594780 creator A5016012778 @default.
• W2884594780 creator A5023043347 @default.
• W2884594780 creator A5028049188 @default.
• W2884594780 creator A5069398757 @default.
• W2884594780 date "2018-09-01" @default.
• W2884594780 modified "2023-09-26" @default.
• W2884594780 title "Chemogenetic Manipulation of Dorsal Hippocampal Astrocytes Protects Against the Development of Stress-enhanced Fear Learning" @default.
• W2884594780 cites W1440335865 @default.
• W2884594780 cites W1563267988 @default.
• W2884594780 cites W1950113474 @default.
• W2884594780 cites W1967490301 @default.
• W2884594780 cites W1979019425 @default.
• W2884594780 cites W1989228397 @default.
• W2884594780 cites W1991513272 @default.
• W2884594780 cites W1993364340 @default.
• W2884594780 cites W1997123576 @default.
• W2884594780 cites W2001986928 @default.
• W2884594780 cites W2004331086 @default.
• W2884594780 cites W2008969164 @default.
• W2884594780 cites W2012121005 @default.
• W2884594780 cites W2015284998 @default.
• W2884594780 cites W2015455559 @default.
• W2884594780 cites W2019954351 @default.
• W2884594780 cites W2021239864 @default.
• W2884594780 cites W2032505039 @default.
• W2884594780 cites W2040937016 @default.
• W2884594780 cites W2041383924 @default.
• W2884594780 cites W2041384106 @default.
• W2884594780 cites W2043275406 @default.
• W2884594780 cites W2053685935 @default.
• W2884594780 cites W2054601951 @default.
• W2884594780 cites W2057681905 @default.
• W2884594780 cites W2059150405 @default.
• W2884594780 cites W2066170543 @default.
• W2884594780 cites W2067511308 @default.
• W2884594780 cites W2078181370 @default.
• W2884594780 cites W2088519055 @default.
• W2884594780 cites W2097547448 @default.
• W2884594780 cites W2103901522 @default.
• W2884594780 cites W2114418219 @default.
• W2884594780 cites W2117439876 @default.
• W2884594780 cites W2120880599 @default.
• W2884594780 cites W2121667809 @default.
• W2884594780 cites W2127621191 @default.
• W2884594780 cites W2127799485 @default.
• W2884594780 cites W2136920852 @default.
• W2884594780 cites W2137689778 @default.
• W2884594780 cites W2149997622 @default.
• W2884594780 cites W2154380548 @default.
• W2884594780 cites W2163329040 @default.
• W2884594780 cites W2163639252 @default.
• W2884594780 cites W2169505641 @default.
• W2884594780 cites W2197177898 @default.
• W2884594780 cites W2284615312 @default.
• W2884594780 cites W2334132217 @default.
• W2884594780 cites W2417295330 @default.
• W2884594780 cites W2462700979 @default.
• W2884594780 cites W2478122494 @default.
• W2884594780 cites W2500216776 @default.
• W2884594780 cites W2510094205 @default.
• W2884594780 cites W2572094849 @default.
• W2884594780 cites W2591693802 @default.
• W2884594780 cites W2602823808 @default.
• W2884594780 cites W2736217419 @default.
• W2884594780 cites W2742705977 @default.
• W2884594780 cites W2757120791 @default.
• W2884594780 cites W2760721217 @default.
• W2884594780 cites W2804560798 @default.
• W2884594780 doi "https://doi.org/10.1016/j.neuroscience.2018.07.015" @default.
• W2884594780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30030056" @default.
• W2884594780 hasPublicationYear "2018" @default.
• W2884594780 type Work @default.
• W2884594780 sameAs 2884594780 @default.
• W2884594780 citedByCount "34" @default.
• W2884594780 countsByYear W28845947802018 @default.
• W2884594780 countsByYear W28845947802019 @default.
• W2884594780 countsByYear W28845947802020 @default.
• W2884594780 countsByYear W28845947802021 @default.
• W2884594780 countsByYear W28845947802022 @default.
• W2884594780 countsByYear W28845947802023 @default.
• W2884594780 crossrefType "journal-article" @default.
• W2884594780 hasAuthorship W2884594780A5001688558 @default.
• W2884594780 hasAuthorship W2884594780A5016012778 @default.
• W2884594780 hasAuthorship W2884594780A5023043347 @default.
• W2884594780 hasAuthorship W2884594780A5028049188 @default.
• W2884594780 hasAuthorship W2884594780A5069398757 @default.
• W2884594780 hasConcept C112592302 @default.
• W2884594780 hasConcept C148762608 @default.
• W2884594780 hasConcept C169760540 @default.
• W2884594780 hasConcept C17077164 @default.
• W2884594780 hasConcept C187541742 @default.
• W2884594780 hasConcept C2777542381 @default.
• W2884594780 hasConcept C2781161787 @default.
• W2884594780 hasConcept C40209533 @default.
• W2884594780 hasConcept C529278444 @default.

• next