Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884598610> ?p ?o ?g. }
- W2884598610 abstract "B-cell activating factor of the tumour necrosis factor family (BAFF) plays a role in autoantibody production and is elevated in dermatomyositis (DM) and anti-Jo-1-positive polymyositis (PM). We investigated the inter-relationships between serum levels of BAFF, anti-Jo-1 autoantibodies, and disease activity.Serum levels of BAFF and anti-Jo-1 antibodies measured by enzyme-linked immunosorbent assay (ELISA) were compared to levels of myoglobin, creatine kinase (CK), aminotransferases (alanine (ALT) and aspartate (AST)), C-reactive protein (CRP), and disease activity assessed by the Myositis Disease Activity Assessment Tool in 63 anti-Jo-1 antibody-positive DM/PM patients. Serial serum samples collected at 2 (46 cases) and 3-5 time points (23 cases) were included. Relationships between BAFF, anti-Jo-1, disease activity, CRP, and their longitudinal changes were evaluated using correlation analysis, multiple regression (MR), path analysis (PA), and hierarchical linear models (HLM).Cross-sectional assessment demonstrated significant correlations between the levels of BAFF and anti-Jo-1 antibodies which were associated with levels of CK, myoglobin, AST, and CRP, as well as multivariate associations between BAFF, anti-Jo-1 antibodies, and CK levels. PA revealed direct effects of anti-Jo-1 antibodies on CK (β = 0.41) and both direct (β = 0.42) and indirect (through anti-Jo-1 antibodies; β = 0.17) effects of BAFF on CK. Changes in levels of both BAFF and anti-Jo-1 between two time points (Δ) were associated with Δmyoglobin and Δaminotransferases and changes of BAFF correlated with ΔCK, Δcutaneous, Δmuscle, Δglobal, and Δskeletal disease activities. The longitudinal analysis showed a high intra-individual variability of serum levels of BAFF over time (97%) which could predict 79% of the variance in anti-Jo-1 levels. The anti-Jo-1 variability was explained by inter-individual differences (68%). The close longitudinal relationship between levels of BAFF, anti-Jo-1, and disease activity was supported by high proportions of their variance explained with serum levels of CK and CRP or pulmonary and muscle activities.Our findings of associations between levels of BAFF and anti-Jo-1 antibodies in serum and myositis activity suggest a role of this cytokine in disease-specific autoantibody production as part of disease mechanisms, and support BAFF as a potential target for intervention in anti-Jo-1-positive myositis patients." @default.
- W2884598610 created "2018-08-03" @default.
- W2884598610 creator A5006308968 @default.
- W2884598610 creator A5010887266 @default.
- W2884598610 creator A5011002229 @default.
- W2884598610 creator A5019763858 @default.
- W2884598610 creator A5034269211 @default.
- W2884598610 creator A5049445685 @default.
- W2884598610 creator A5059480767 @default.
- W2884598610 creator A5079921904 @default.
- W2884598610 date "2018-07-27" @default.
- W2884598610 modified "2023-10-16" @default.
- W2884598610 title "Serum levels of B-cell activating factor of the TNF family (BAFF) correlate with anti-Jo-1 autoantibodies levels and disease activity in patients with anti-Jo-1positive polymyositis and dermatomyositis" @default.
- W2884598610 cites W1576993812 @default.
- W2884598610 cites W1587682423 @default.
- W2884598610 cites W1704455478 @default.
- W2884598610 cites W184510336 @default.
- W2884598610 cites W1938959953 @default.
- W2884598610 cites W1969808218 @default.
- W2884598610 cites W1974113719 @default.
- W2884598610 cites W1975085076 @default.
- W2884598610 cites W1980510932 @default.
- W2884598610 cites W1983463618 @default.
- W2884598610 cites W1987213193 @default.
- W2884598610 cites W1988915671 @default.
- W2884598610 cites W1991793242 @default.
- W2884598610 cites W2013478286 @default.
- W2884598610 cites W2013679387 @default.
- W2884598610 cites W2014956545 @default.
- W2884598610 cites W2029980677 @default.
- W2884598610 cites W2049511380 @default.
- W2884598610 cites W2052079772 @default.
- W2884598610 cites W2054352916 @default.
- W2884598610 cites W2062857005 @default.
- W2884598610 cites W2081595928 @default.
- W2884598610 cites W2083617728 @default.
- W2884598610 cites W2094910932 @default.
- W2884598610 cites W2096946410 @default.
- W2884598610 cites W2097671812 @default.
- W2884598610 cites W2104077617 @default.
- W2884598610 cites W2105294966 @default.
- W2884598610 cites W2105594762 @default.
- W2884598610 cites W2108971388 @default.
- W2884598610 cites W2125816072 @default.
- W2884598610 cites W2127850323 @default.
- W2884598610 cites W2128198448 @default.
- W2884598610 cites W2136615407 @default.
- W2884598610 cites W2140393033 @default.
- W2884598610 cites W2151403954 @default.
- W2884598610 cites W2162800454 @default.
- W2884598610 cites W2166022914 @default.
- W2884598610 cites W2166714841 @default.
- W2884598610 cites W2195720705 @default.
- W2884598610 cites W2217038405 @default.
- W2884598610 cites W2314311014 @default.
- W2884598610 cites W2322139300 @default.
- W2884598610 cites W2742891217 @default.
- W2884598610 doi "https://doi.org/10.1186/s13075-018-1650-8" @default.
- W2884598610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6062864" @default.
- W2884598610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30053824" @default.
- W2884598610 hasPublicationYear "2018" @default.
- W2884598610 type Work @default.
- W2884598610 sameAs 2884598610 @default.
- W2884598610 citedByCount "20" @default.
- W2884598610 countsByYear W28845986102019 @default.
- W2884598610 countsByYear W28845986102020 @default.
- W2884598610 countsByYear W28845986102021 @default.
- W2884598610 countsByYear W28845986102022 @default.
- W2884598610 countsByYear W28845986102023 @default.
- W2884598610 crossrefType "journal-article" @default.
- W2884598610 hasAuthorship W2884598610A5006308968 @default.
- W2884598610 hasAuthorship W2884598610A5010887266 @default.
- W2884598610 hasAuthorship W2884598610A5011002229 @default.
- W2884598610 hasAuthorship W2884598610A5019763858 @default.
- W2884598610 hasAuthorship W2884598610A5034269211 @default.
- W2884598610 hasAuthorship W2884598610A5049445685 @default.
- W2884598610 hasAuthorship W2884598610A5059480767 @default.
- W2884598610 hasAuthorship W2884598610A5079921904 @default.
- W2884598610 hasBestOaLocation W28845986101 @default.
- W2884598610 hasConcept C126322002 @default.
- W2884598610 hasConcept C159654299 @default.
- W2884598610 hasConcept C163764329 @default.
- W2884598610 hasConcept C170286685 @default.
- W2884598610 hasConcept C198451711 @default.
- W2884598610 hasConcept C203014093 @default.
- W2884598610 hasConcept C2776670291 @default.
- W2884598610 hasConcept C2778453870 @default.
- W2884598610 hasConcept C2778751314 @default.
- W2884598610 hasConcept C2779075594 @default.
- W2884598610 hasConcept C2779387793 @default.
- W2884598610 hasConcept C36880943 @default.
- W2884598610 hasConcept C71924100 @default.
- W2884598610 hasConceptScore W2884598610C126322002 @default.
- W2884598610 hasConceptScore W2884598610C159654299 @default.
- W2884598610 hasConceptScore W2884598610C163764329 @default.
- W2884598610 hasConceptScore W2884598610C170286685 @default.
- W2884598610 hasConceptScore W2884598610C198451711 @default.
- W2884598610 hasConceptScore W2884598610C203014093 @default.
- W2884598610 hasConceptScore W2884598610C2776670291 @default.
- W2884598610 hasConceptScore W2884598610C2778453870 @default.