Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884636082> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2884636082 abstract "PAF-acether-aggregated rabbit platelets did not respond to a second challenge with the same agonist after their spontaneous disaggregation, but still aggregated in the presence of arachidonic acid (AA). When using 1 nM of PAF-acether in the first stimulation, aggregation in response to a second challenge with the same dose was nil. However, when 0.34 nM was used in the first step, aggregation in response to 0.64 nM PAF-acether was 59 96, as compared to control platelets. By contrast, aggregation of platelets pretreated with 1 nM PAF-acether was 72 % in the presence of 2.8 uM AA. Adding fibrinogen (0.34 mg/ml) before the second stimulation did not modify the desensitization pehnom- enon. Supernatants from platelets desensitized with 1 nM PAF- acether exhibited neither aggregating nor inhibitory activity. PAF-acether-induced desensitization could always be overcome, since aspirin-pretreated platelets first stimulated with 10 nM PAF-acether still aggregated with 100 nM of the same agonist, i.e. when using 100 times the amount which induced maximal aggregation. All our experiments were performed in the presence of ADP scavengers and, except for AA-induced aggregation, aspirin. We tested PAF-acether from 4 different cell origins and the semi-synthetic and synthetic compounds. Platelets were cross- desensitized towards PAF-acether from any source. Totally synthetic PAF-acether bearing aC,, alkyl chain at position 1 of the glycerol moiety desensitized platelets as well as the C.g synthetic analog. Lyso-PAF-acether (i.e. a compound lackifig tne acetyl group at the position 2 of the glycerol) (0.5-10.0 nM) and PAF-acether enantiomer (0.5-5.0 nM) neither aggregated nor desensitized platelets to PAF-acether. These results indicate that 1) PAF-acether from any source exhibit at least an identical active molecular site ; 2) the presence and the stereospecific position of the 2-acetyl group are critical for the interaction of PAF-acether with platelets, a result which could indicate the existence of a platelet acceptor (receptor) for PAF-acether. However, these postulated platelet membrane acceptors were never saturated even using very high amounts of the agonist." @default.
- W2884636082 created "2018-08-03" @default.
- W2884636082 creator A5031597095 @default.
- W2884636082 creator A5044684532 @default.
- W2884636082 creator A5062365940 @default.
- W2884636082 creator A5090474227 @default.
- W2884636082 date "1981-01-01" @default.
- W2884636082 modified "2023-10-17" @default.
- W2884636082 title "Specific Desensitization Of Washed Rabbit Platelets By Paf-Acether And Derivatives" @default.
- W2884636082 doi "https://doi.org/10.1055/s-0038-1652802" @default.
- W2884636082 hasPublicationYear "1981" @default.
- W2884636082 type Work @default.
- W2884636082 sameAs 2884636082 @default.
- W2884636082 citedByCount "1" @default.
- W2884636082 crossrefType "proceedings-article" @default.
- W2884636082 hasAuthorship W2884636082A5031597095 @default.
- W2884636082 hasAuthorship W2884636082A5044684532 @default.
- W2884636082 hasAuthorship W2884636082A5062365940 @default.
- W2884636082 hasAuthorship W2884636082A5090474227 @default.
- W2884636082 hasBestOaLocation W28846360821 @default.
- W2884636082 hasConcept C12554922 @default.
- W2884636082 hasConcept C126322002 @default.
- W2884636082 hasConcept C134018914 @default.
- W2884636082 hasConcept C170493617 @default.
- W2884636082 hasConcept C185592680 @default.
- W2884636082 hasConcept C2779020240 @default.
- W2884636082 hasConcept C2779779143 @default.
- W2884636082 hasConcept C2779884254 @default.
- W2884636082 hasConcept C38652104 @default.
- W2884636082 hasConcept C41008148 @default.
- W2884636082 hasConcept C55493867 @default.
- W2884636082 hasConcept C71924100 @default.
- W2884636082 hasConcept C86803240 @default.
- W2884636082 hasConcept C89560881 @default.
- W2884636082 hasConcept C95444343 @default.
- W2884636082 hasConcept C98274493 @default.
- W2884636082 hasConceptScore W2884636082C12554922 @default.
- W2884636082 hasConceptScore W2884636082C126322002 @default.
- W2884636082 hasConceptScore W2884636082C134018914 @default.
- W2884636082 hasConceptScore W2884636082C170493617 @default.
- W2884636082 hasConceptScore W2884636082C185592680 @default.
- W2884636082 hasConceptScore W2884636082C2779020240 @default.
- W2884636082 hasConceptScore W2884636082C2779779143 @default.
- W2884636082 hasConceptScore W2884636082C2779884254 @default.
- W2884636082 hasConceptScore W2884636082C38652104 @default.
- W2884636082 hasConceptScore W2884636082C41008148 @default.
- W2884636082 hasConceptScore W2884636082C55493867 @default.
- W2884636082 hasConceptScore W2884636082C71924100 @default.
- W2884636082 hasConceptScore W2884636082C86803240 @default.
- W2884636082 hasConceptScore W2884636082C89560881 @default.
- W2884636082 hasConceptScore W2884636082C95444343 @default.
- W2884636082 hasConceptScore W2884636082C98274493 @default.
- W2884636082 hasLocation W28846360821 @default.
- W2884636082 hasOpenAccess W2884636082 @default.
- W2884636082 hasPrimaryLocation W28846360821 @default.
- W2884636082 hasRelatedWork W1969584081 @default.
- W2884636082 hasRelatedWork W1995702172 @default.
- W2884636082 hasRelatedWork W1998667028 @default.
- W2884636082 hasRelatedWork W2002511097 @default.
- W2884636082 hasRelatedWork W2003964520 @default.
- W2884636082 hasRelatedWork W2003991085 @default.
- W2884636082 hasRelatedWork W2025571159 @default.
- W2884636082 hasRelatedWork W2026006417 @default.
- W2884636082 hasRelatedWork W2031725407 @default.
- W2884636082 hasRelatedWork W2040172391 @default.
- W2884636082 hasRelatedWork W2065519705 @default.
- W2884636082 hasRelatedWork W2069421750 @default.
- W2884636082 hasRelatedWork W2093552376 @default.
- W2884636082 hasRelatedWork W2182881752 @default.
- W2884636082 hasRelatedWork W2401429230 @default.
- W2884636082 hasRelatedWork W2406269561 @default.
- W2884636082 hasRelatedWork W2434079510 @default.
- W2884636082 hasRelatedWork W2474775742 @default.
- W2884636082 hasRelatedWork W2559928571 @default.
- W2884636082 hasRelatedWork W2883588683 @default.
- W2884636082 isParatext "false" @default.
- W2884636082 isRetracted "false" @default.
- W2884636082 magId "2884636082" @default.
- W2884636082 workType "article" @default.