FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884652818> ?p ?o ?g. }

• W2884652818 endingPage "131" @default.
• W2884652818 startingPage "126" @default.
• W2884652818 abstract "Vascular smooth muscle cells (VSMCs) contractile- synthetic phenotypic conversion takes responsibility in the atherosclerotic plaque formation by abnormal synthesis, secretion and deposition of extracellular matrix (ECM). Matrine exerts therapeutic effects on both cardiovascular diseases and organ fibrosis. In this study, we investigated matrine's inhibitory effect and mechanisms on AGEs- induced VSMC contractile- synthetic phenotypic conversion. Cultured human coronary smooth muscle cells (HCSMCs) were exposed to AGEs. Matrine at serially diluted concentrations were used to treat the cells. HCSMCs phenotype was identified by immunofluorescent staining of contractile phenotypic markers including mooth muscle myosin heavy chain (MYH11) and smooth muscle α-actin (ACTA2). Sircol collagen assay was used to assess the collagen secretion level. Notch signaling activation was determined by luciferase assay. Western blotting was used to evaluate expression levels of collagen I, collagen VIII, Delta-like (Dll)1, Dll3, Dll4, Jagged1, Jagged2, Notch intracellular domain (NICD)1 and Hes family basic helix-loop-helix (bHLH) transcription factor1 (HES1). Matrine pre-treatment recovered the AGEs- induced contractile- synthetic phenotypic conversion by increasing MYH11 and ACTA2 in HCSMCs. Matrine reduced AGEs- mediated activation of Notch signaling, down-regulated expression levels of NICD1, HES1, collagen I and collagen VIII and collagen secretion contents in HCSMCs. Matrine inhibited expression level of Dll4 without affecting other Notch ligands including Dll1, Dll3, Jagged1 and Jagged2 in HCSMCs exposed to AGEs. These results suggested that AGEs exposure facilitated the contractile- synthetic phenotypic conversion of HCSMCs. Matrine blocked this phenotypic conversion by suppressing Dll4- Notch signaling pathway activation." @default.
• W2884652818 created "2018-08-03" @default.
• W2884652818 creator A5017383224 @default.
• W2884652818 creator A5017774638 @default.
• W2884652818 creator A5027674143 @default.
• W2884652818 creator A5052135538 @default.
• W2884652818 creator A5059564497 @default.
• W2884652818 creator A5078576975 @default.
• W2884652818 creator A5082797513 @default.
• W2884652818 date "2018-09-01" @default.
• W2884652818 modified "2023-09-28" @default.
• W2884652818 title "Matrine blocks AGEs- induced HCSMCs phenotypic conversion via suppressing Dll4-Notch pathway" @default.
• W2884652818 cites W151816741 @default.
• W2884652818 cites W1795830070 @default.
• W2884652818 cites W1983384768 @default.
• W2884652818 cites W1997447288 @default.
• W2884652818 cites W2005856948 @default.
• W2884652818 cites W2022261829 @default.
• W2884652818 cites W2026890415 @default.
• W2884652818 cites W2034980513 @default.
• W2884652818 cites W2035220761 @default.
• W2884652818 cites W2037753075 @default.
• W2884652818 cites W2039068212 @default.
• W2884652818 cites W2069199025 @default.
• W2884652818 cites W2071666861 @default.
• W2884652818 cites W2072878932 @default.
• W2884652818 cites W2076619655 @default.
• W2884652818 cites W2077628510 @default.
• W2884652818 cites W2107704022 @default.
• W2884652818 cites W2121822802 @default.
• W2884652818 cites W2126294799 @default.
• W2884652818 cites W2142653769 @default.
• W2884652818 cites W2147298899 @default.
• W2884652818 cites W2153233529 @default.
• W2884652818 cites W2153249592 @default.
• W2884652818 cites W2153393998 @default.
• W2884652818 cites W2160044615 @default.
• W2884652818 cites W2160342986 @default.
• W2884652818 cites W2272921018 @default.
• W2884652818 cites W2274924551 @default.
• W2884652818 cites W2285401612 @default.
• W2884652818 cites W2339355704 @default.
• W2884652818 cites W2347810706 @default.
• W2884652818 cites W2411802291 @default.
• W2884652818 cites W2514558831 @default.
• W2884652818 cites W2599880022 @default.
• W2884652818 cites W2601156194 @default.
• W2884652818 cites W2606221513 @default.
• W2884652818 cites W2726871304 @default.
• W2884652818 cites W2755654621 @default.
• W2884652818 cites W4294349352 @default.
• W2884652818 doi "https://doi.org/10.1016/j.ejphar.2018.07.051" @default.
• W2884652818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30063915" @default.
• W2884652818 hasPublicationYear "2018" @default.
• W2884652818 type Work @default.
• W2884652818 sameAs 2884652818 @default.
• W2884652818 citedByCount "14" @default.
• W2884652818 countsByYear W28846528182019 @default.
• W2884652818 countsByYear W28846528182020 @default.
• W2884652818 countsByYear W28846528182021 @default.
• W2884652818 countsByYear W28846528182022 @default.
• W2884652818 countsByYear W28846528182023 @default.
• W2884652818 crossrefType "journal-article" @default.
• W2884652818 hasAuthorship W2884652818A5017383224 @default.
• W2884652818 hasAuthorship W2884652818A5017774638 @default.
• W2884652818 hasAuthorship W2884652818A5027674143 @default.
• W2884652818 hasAuthorship W2884652818A5052135538 @default.
• W2884652818 hasAuthorship W2884652818A5059564497 @default.
• W2884652818 hasAuthorship W2884652818A5078576975 @default.
• W2884652818 hasAuthorship W2884652818A5082797513 @default.
• W2884652818 hasConcept C104317684 @default.
• W2884652818 hasConcept C127716648 @default.
• W2884652818 hasConcept C134018914 @default.
• W2884652818 hasConcept C153911025 @default.
• W2884652818 hasConcept C161879069 @default.
• W2884652818 hasConcept C185592680 @default.
• W2884652818 hasConcept C189165786 @default.
• W2884652818 hasConcept C2776545273 @default.
• W2884652818 hasConcept C2779395532 @default.
• W2884652818 hasConcept C2780283210 @default.
• W2884652818 hasConcept C2992686903 @default.
• W2884652818 hasConcept C43617362 @default.
• W2884652818 hasConcept C55493867 @default.
• W2884652818 hasConcept C62478195 @default.
• W2884652818 hasConcept C86803240 @default.
• W2884652818 hasConcept C95444343 @default.
• W2884652818 hasConceptScore W2884652818C104317684 @default.
• W2884652818 hasConceptScore W2884652818C127716648 @default.
• W2884652818 hasConceptScore W2884652818C134018914 @default.
• W2884652818 hasConceptScore W2884652818C153911025 @default.
• W2884652818 hasConceptScore W2884652818C161879069 @default.
• W2884652818 hasConceptScore W2884652818C185592680 @default.
• W2884652818 hasConceptScore W2884652818C189165786 @default.
• W2884652818 hasConceptScore W2884652818C2776545273 @default.
• W2884652818 hasConceptScore W2884652818C2779395532 @default.
• W2884652818 hasConceptScore W2884652818C2780283210 @default.
• W2884652818 hasConceptScore W2884652818C2992686903 @default.
• W2884652818 hasConceptScore W2884652818C43617362 @default.

• next