FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884656166> ?p ?o ?g. }

• W2884656166 abstract "The present study were Management of Diabetes mellitus is a global problem, successful treatment is veryimportant for preventing or at least delaying the onset of long term diabetic complications likediabetic neuropathy, nephropathy, retinopathy, erectile dysfunction, hypertension and injurycaused by ischaemic and reperfusion. Through nature in the form of herbal medicines or drugswith very minimal adverse effects are preferred when compared to the available synthetic drugsto treat such chronic disease and disorders. Herbal drugs as therapeutic agents are a nature’sboon when compared to the severe adverse effects of the allopathic medical practice fordiabetes, despite the fact that the search for a complete and permanent cure for the disease isbeing pursued uncompromisingly by eluding physicians and researchers. These herbalremedies which exemplifies the process of symbiosis still remains unfamiliar up to datatechnical advances, which has fashioned a marvelous scope for folk lore or traditionalmedicines .It is supposed that the tradition medicines used for the treatment of diabetes mellitussatisfy the sequence of complication of the disease.Even though, the traditional medicinal plants are used to cure the disease from humanorigin, scientific validation of such medicinal plants are necessary and also a scientific researchto prove its pharmacological and therapeutic efficacy is became vital.Nymphaea pubescens willd is having the anti-diabetic activity. As per the literaturereview still no anti-diabetic activity has been reported on this whole plant. Hence, this studyhas been taken to explore the anti-diabetic potential of Nymphaea pubescens willd onstreptozotocin induced diabetes in wistar albino rats.DISCUSSION AND CONCLUSION:The ethanolic extract from whole plant of Nymphaea Pubescens were subjected topreliminary phytochemical analysis which shown presence of flavonoids, alkaloids, tannins,proteins, steroids and phenol with absence of saponins and anthroquinones.Acute oral toxicity studies of EENP did not produce any mortality or signs of toxicity atthe dose of 2000 mg/kg b.w/p.o, in experimental rats.The anti-hyperglycemic effects of the plants is due to their ability to restore the functionof pancreatic tissues by causing an increase in insulin output or inhibit the intestinal absorptionof glucose or to the facilitation of metabolites in insulin dependent processes. Hence, treatmentwith herbal drugs has an effect on protecting b cells and smoothing out fluctuation in glucoselevels72 The present study evalulation of anti-diabetic activity of whole plant of Nymphaeapubescens STZ induced diabetic rats.Experimental induction of hyperglycemia with STZ is associated with the characteristicloss of body weight which is due to loss or degradation of structural proteins it leads to increasedmuscle wasting and due to loss of tissue protein, as the structural proteins are known tocontribute to body weight. Diabetic rats treated with glibenclamide and EENP showed increasedbody weight when compared to untreated diabetic animals. It may be due to increased insulinsecretion and glycemic control of EENP.Reduced glucose transport or absorption from the gut, extra pancreatic action probablyby stimulation of glucose utilization in peripheral tissues, increase in glycogenic or glycolyticenzyme activities in peripheral tissues, decrease in the secretion of counter-regulatory hormoneslike glucagon, growth hormones are the possible mechanisms involved with suppressing bloodglucose levels. The glibenclamide, stimulating insulin secretion from pancreatic β cellsprincipally by inhibiting ATP sensitive KATP channels in the plasma membrane and decreasesthe blood glucose level73. Blood glucose level decreased significantly in glibenclamide and EENP treated diabetic rats and the histopathology of pancreas showed normal islets in pancreaswith normal anatomy compared with normal rats which may be due to the anti-diabetic activity.Hyperglycaemia is accompanied with dyslipidemia under normal circumstances; insulinactivates the enzyme lipoprotein lipase, which hydrolyses triglycerides. However, in diabeticstate lipoprotein lipase is not activated due to insulin deficiency, resulting in hypertriglyceridemia, and insulin deficiency is also associated with hyper cholesterolemia due tometabolic abnormalities. The dyslipidemia is characterized by increase in TC, LDL, VLDL, TGand fall in HDL which is observed in STZ induced diabetic rats74. The diabetic rats treated withglibenclamide and EENP showed reduced severity of dyslipidemia with decrease in TC, LDL,VLDL, TG and increase in HDL.Both SGOT and SGPT enzyme levels get elevated during liver damage which is morein diabetic rats75. The diabetic rats treated with glibenclamide and EENP reduced the SGOT andSGPT level. The liver histopathology of STZ induced diabetic rats showed centrilobularnecrosis accompanied by fatty changes and ballooning degeneration in the hepatocytestreatment with EENP reversed in diabetic rats treated with glibenclamide and EENP whichindicates that the liver damage is reduced in EENP treated group.The diabetic hyperglycaemia induces elevation of the serum levels of creatinine whichare significant markers of renal dysfunction, The treatment of EENP in rats showed markeddecrease in serum creatinine levels in diabetic animals." @default.
• W2884656166 created "2018-08-03" @default.
• W2884656166 creator A5074072708 @default.
• W2884656166 date "2017-10-01" @default.
• W2884656166 modified "2023-09-27" @default.
• W2884656166 title "Evaluation on Anti-Diabetic Effect of Ethanolic Extract of Whole Plant of Nymphaea Pubescens on Streptozotocin Induced Diabetes in Wistar Rats" @default.
• W2884656166 hasPublicationYear "2017" @default.
• W2884656166 type Work @default.
• W2884656166 sameAs 2884656166 @default.
• W2884656166 citedByCount "0" @default.
• W2884656166 crossrefType "dissertation" @default.
• W2884656166 hasAuthorship W2884656166A5074072708 @default.
• W2884656166 hasConcept C126322002 @default.
• W2884656166 hasConcept C134018914 @default.
• W2884656166 hasConcept C177713679 @default.
• W2884656166 hasConcept C197934379 @default.
• W2884656166 hasConcept C2779134260 @default.
• W2884656166 hasConcept C2779158651 @default.
• W2884656166 hasConcept C2779829184 @default.
• W2884656166 hasConcept C555293320 @default.
• W2884656166 hasConcept C556039675 @default.
• W2884656166 hasConcept C71924100 @default.
• W2884656166 hasConcept C98274493 @default.
• W2884656166 hasConceptScore W2884656166C126322002 @default.
• W2884656166 hasConceptScore W2884656166C134018914 @default.
• W2884656166 hasConceptScore W2884656166C177713679 @default.
• W2884656166 hasConceptScore W2884656166C197934379 @default.
• W2884656166 hasConceptScore W2884656166C2779134260 @default.
• W2884656166 hasConceptScore W2884656166C2779158651 @default.
• W2884656166 hasConceptScore W2884656166C2779829184 @default.
• W2884656166 hasConceptScore W2884656166C555293320 @default.
• W2884656166 hasConceptScore W2884656166C556039675 @default.
• W2884656166 hasConceptScore W2884656166C71924100 @default.
• W2884656166 hasConceptScore W2884656166C98274493 @default.
• W2884656166 hasLocation W28846561661 @default.
• W2884656166 hasOpenAccess W2884656166 @default.
• W2884656166 hasPrimaryLocation W28846561661 @default.
• W2884656166 hasRelatedWork W1492846777 @default.
• W2884656166 hasRelatedWork W1991912777 @default.
• W2884656166 hasRelatedWork W2010458081 @default.
• W2884656166 hasRelatedWork W2016449378 @default.
• W2884656166 hasRelatedWork W2042219020 @default.
• W2884656166 hasRelatedWork W2094943143 @default.
• W2884656166 hasRelatedWork W2105057621 @default.
• W2884656166 hasRelatedWork W2158717301 @default.
• W2884656166 hasRelatedWork W2181953783 @default.
• W2884656166 hasRelatedWork W2284333748 @default.
• W2884656166 hasRelatedWork W2318135496 @default.
• W2884656166 hasRelatedWork W2369927492 @default.
• W2884656166 hasRelatedWork W2398316856 @default.
• W2884656166 hasRelatedWork W2505369960 @default.
• W2884656166 hasRelatedWork W2519109113 @default.
• W2884656166 hasRelatedWork W2781823897 @default.
• W2884656166 hasRelatedWork W2800748798 @default.
• W2884656166 hasRelatedWork W2948118921 @default.
• W2884656166 hasRelatedWork W3014972546 @default.
• W2884656166 hasRelatedWork W3025163598 @default.
• W2884656166 isParatext "false" @default.
• W2884656166 isRetracted "false" @default.
• W2884656166 magId "2884656166" @default.
• W2884656166 workType "dissertation" @default.