FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884676598> ?p ?o ?g. }

• W2884676598 endingPage "122" @default.
• W2884676598 startingPage "122" @default.
• W2884676598 abstract "Background: E. coli and K. pneumoniae are common causes of both community- and hospital-acquired bloodstream infections (BSI). Resistance to commonly used antibiotics threatens the treatment of these infections. We describe the antibiotic resistance profiles and outcomes of CA- and HA-BSI with these organisms in a tertiary hospital in Cape Town, South Africa. Methods & Materials: Patients with E. coli (n = 70) and K. pneumoniae (n = 70) bacteraemia identified at Tygerberg Hospital between April 2015 and March 2016 were included. Admission and discharge dates, BC collection date, and outcome were obtained through record review. A 72-hour cut-off differentiated HA- and CA-infections. ESBL-genes were characterised by PCR and DNA sequencing; isolates were typed using REP-PCR and PFGE. Chi-square and Mann-Whitney tests were used to estimate the significance of correlation. Results: 45% of patients were male, and 31% were paediatric (<18 years); 66% of BSI were hospital-acquired. K. pneumoniae accounted for 61% of HA-isolates; 72% of CA-isolates were E. coli. 56% of K. pneumoniae and 16% of E. coli were cephalosporin resistant (presumed ESBL). Patients spent an average of 11 days (16,9 HA; 0,7 CA) in hospital before BC collection. HA-isolates were associated with cephalosporin resistance. Quinolone resistance was similar in both CA and HA E. coli (24% vs 25%); gentamicin resistance was more common in CA E. coli (21% vs 11%). The 30-day mortality rate was 30%, with no association between mortality and cephalosporin resistance or HA-infection. All isolates were carbapenemase gene negative. TEM and SHV were the commonest β-lactamases in E. coli (70%) and K. pneumoniae (84,3%) respectively. Multiple β-lactamase genes were present in 60% of K. pneumoniae isolates, and 5.7% of E. coli isolates. Strain typing showed substantial diversity among both organisms with minimal clustering, suggesting multiple clones in the hospital. Conclusion: The association between antibiotic resistance and hospital acquisition is not surprising. Resistance rates in CA-infections deserve further attention, and may reflect antibiotic usage patterns in the community. More detailed prospective studies are required to better understand the effect of resistance on outcomes. The diversity among both HA- and CA-isolates precluded any associations between strain type and resistance phenotype or genotype." @default.
• W2884676598 created "2018-08-03" @default.
• W2884676598 creator A5008016027 @default.
• W2884676598 creator A5068738780 @default.
• W2884676598 creator A5086584366 @default.
• W2884676598 date "2018-08-01" @default.
• W2884676598 modified "2023-09-26" @default.
• W2884676598 title "The epidemiology of Gram negative bacteraemia at Tygerberg Hospital" @default.
• W2884676598 cites W1481519324 @default.
• W2884676598 cites W1483247593 @default.
• W2884676598 cites W1515864879 @default.
• W2884676598 cites W1598136901 @default.
• W2884676598 cites W1796585208 @default.
• W2884676598 cites W1855450948 @default.
• W2884676598 cites W1856609834 @default.
• W2884676598 cites W1902535075 @default.
• W2884676598 cites W1904484517 @default.
• W2884676598 cites W1920534944 @default.
• W2884676598 cites W1927106291 @default.
• W2884676598 cites W1947958018 @default.
• W2884676598 cites W1951178169 @default.
• W2884676598 cites W1964148388 @default.
• W2884676598 cites W1973676386 @default.
• W2884676598 cites W1980850215 @default.
• W2884676598 cites W1981531221 @default.
• W2884676598 cites W1983883238 @default.
• W2884676598 cites W1986946784 @default.
• W2884676598 cites W2001838110 @default.
• W2884676598 cites W2007510271 @default.
• W2884676598 cites W2011121341 @default.
• W2884676598 cites W2013547178 @default.
• W2884676598 cites W2014287197 @default.
• W2884676598 cites W2014499961 @default.
• W2884676598 cites W2035755223 @default.
• W2884676598 cites W2037731504 @default.
• W2884676598 cites W2039442221 @default.
• W2884676598 cites W2039553466 @default.
• W2884676598 cites W2052714851 @default.
• W2884676598 cites W2053828698 @default.
• W2884676598 cites W2054445610 @default.
• W2884676598 cites W2068319625 @default.
• W2884676598 cites W2073524740 @default.
• W2884676598 cites W2076196434 @default.
• W2884676598 cites W2079732970 @default.
• W2884676598 cites W2082317013 @default.
• W2884676598 cites W2086368616 @default.
• W2884676598 cites W2096525273 @default.
• W2884676598 cites W2097081283 @default.
• W2884676598 cites W2098618245 @default.
• W2884676598 cites W2098721184 @default.
• W2884676598 cites W2101996554 @default.
• W2884676598 cites W2102648116 @default.
• W2884676598 cites W2104843155 @default.
• W2884676598 cites W2106950843 @default.
• W2884676598 cites W2109063350 @default.
• W2884676598 cites W2111368630 @default.
• W2884676598 cites W2112104265 @default.
• W2884676598 cites W2112203749 @default.
• W2884676598 cites W2113701842 @default.
• W2884676598 cites W2123677996 @default.
• W2884676598 cites W2124635476 @default.
• W2884676598 cites W2131946678 @default.
• W2884676598 cites W2133268685 @default.
• W2884676598 cites W2142183671 @default.
• W2884676598 cites W2145037862 @default.
• W2884676598 cites W2149088271 @default.
• W2884676598 cites W2151496242 @default.
• W2884676598 cites W2152127318 @default.
• W2884676598 cites W2153679512 @default.
• W2884676598 cites W2155623469 @default.
• W2884676598 cites W2157370150 @default.
• W2884676598 cites W2157554943 @default.
• W2884676598 cites W2163100965 @default.
• W2884676598 cites W2164278522 @default.
• W2884676598 cites W2164951804 @default.
• W2884676598 cites W2165055228 @default.
• W2884676598 cites W2166785990 @default.
• W2884676598 cites W2169550448 @default.
• W2884676598 cites W2170272276 @default.
• W2884676598 cites W2170605303 @default.
• W2884676598 cites W2171688341 @default.
• W2884676598 cites W2189116376 @default.
• W2884676598 cites W2297477897 @default.
• W2884676598 cites W2298346855 @default.
• W2884676598 cites W2313086788 @default.
• W2884676598 cites W2314985120 @default.
• W2884676598 cites W2317397217 @default.
• W2884676598 cites W2396597555 @default.
• W2884676598 cites W2413463682 @default.
• W2884676598 cites W2513006721 @default.
• W2884676598 cites W2527216252 @default.
• W2884676598 cites W2582469210 @default.
• W2884676598 cites W2594067464 @default.
• W2884676598 cites W2604922170 @default.
• W2884676598 cites W2608489635 @default.
• W2884676598 cites W2784619191 @default.
• W2884676598 doi "https://doi.org/10.1016/j.ijid.2018.04.3693" @default.
• W2884676598 hasPublicationYear "2018" @default.

• next