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- W2884709303 endingPage "738" @default.
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- W2884709303 abstract "Members of the 'Bacillus subtilis group' include some of the most commercially important bacteria, used for the production of a wide range of industrial enzymes and fine biochemicals. Increasingly, group members have been developed for use as animal feed enhancers and antifungal biocontrol agents. The group has long been recognised to produce a range of secondary metabolites and, despite their long history of safe usage, this has resulted in an increased focus on their safety. Traditional methods used to detect the production of secondary metabolites and other potentially harmful compounds have relied on phenotypic tests. Such approaches are time consuming and, in some cases, lack specificity. Nowadays, accessibility to genome data and associated bioinformatical tools provides a powerful means for identifying gene clusters associated with the synthesis of secondary metabolites. This review focuses primarily on well-characterised strains of B. subtilis and B. licheniformis and their synthesis of non-ribosomally synthesised peptides and polyketides. Where known, the activities and toxicities of their secondary metabolites are discussed, together with the limitations of assays currently used to assess their toxicity. Finally, the regulatory framework under which such strains are authorised for use in the production of food and feed enzymes is also reviewed." @default.
- W2884709303 created "2018-08-03" @default.
- W2884709303 creator A5012606565 @default.
- W2884709303 creator A5026960327 @default.
- W2884709303 creator A5048036989 @default.
- W2884709303 creator A5073009948 @default.
- W2884709303 date "2018-07-19" @default.
- W2884709303 modified "2023-10-14" @default.
- W2884709303 title "Secondary metabolite production and the safety of industrially important members of the Bacillus subtilis group" @default.
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