Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884782017> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2884782017 endingPage "10313" @default.
- W2884782017 startingPage "10299" @default.
- W2884782017 abstract "Hepatitis C virus(HCV) is a hepatotrophic virus and a major cause of chronic liver disease,including hepatocellular carcinoma,worldwide. The life cycle of HCV is closely associated with the metabolism of lipids and lipoproteins. The main function of lipoproteins is transporting lipids throughout the body. Triglycerides,free cholesterol,cholesteryl esters,and phospholipids are the major components of the transported lipids. The pathway of HCV assembly and secretion is closely linked to lipoprotein production and secretion,and the infectivity of HCV particles largely depends on the interaction of lipoproteins. Moreover,HCV entry into hepatocytes is strongly influenced by lipoproteins. The key lipoprotein molecules mediating these interactions are apolipoproteins. Apolipoproteins are amphipathic proteins on the surface of a lipoprotein particle,which help stabilize lipoprotein structure. They perform a key role in lipoprotein metabolism by serving as receptor ligands,enzyme co-factors,and lipid transport carriers. Understanding the association between the life cycle of HCV and lipoprotein metabolism is important because each step of the life cycle of HCV that is associated with lipoprotein metabolism is a potential target for anti-HCV therapy. In this article,we first concisely review the nature of lipoprotein and its metabolism to better understand the complicated interaction of HCV with lipoprotein. Then,we review the outline of the processes of HCV assembly,secretion,and entry into hepatocytes,focusing on the association with lipoproteins. Finally,we discuss the clinical aspects of disturbed lipid/lipoprotein metabolism and the significance of dyslipoproteinemia in chronic HCV infection with regard to abnormal apolipoproteins." @default.
- W2884782017 created "2018-08-03" @default.
- W2884782017 creator A5018999139 @default.
- W2884782017 creator A5024095185 @default.
- W2884782017 creator A5039860249 @default.
- W2884782017 creator A5079066313 @default.
- W2884782017 date "2015-01-01" @default.
- W2884782017 modified "2023-09-24" @default.
- W2884782017 title "Chronic hepatitis C virus infection and lipoprotein metabolism" @default.
- W2884782017 hasPublicationYear "2015" @default.
- W2884782017 type Work @default.
- W2884782017 sameAs 2884782017 @default.
- W2884782017 citedByCount "0" @default.
- W2884782017 crossrefType "journal-article" @default.
- W2884782017 hasAuthorship W2884782017A5018999139 @default.
- W2884782017 hasAuthorship W2884782017A5024095185 @default.
- W2884782017 hasAuthorship W2884782017A5039860249 @default.
- W2884782017 hasAuthorship W2884782017A5079066313 @default.
- W2884782017 hasConcept C203014093 @default.
- W2884782017 hasConcept C2522874641 @default.
- W2884782017 hasConcept C2776408679 @default.
- W2884782017 hasConcept C2778163477 @default.
- W2884782017 hasConcept C2780072125 @default.
- W2884782017 hasConcept C4733338 @default.
- W2884782017 hasConcept C49039625 @default.
- W2884782017 hasConcept C55493867 @default.
- W2884782017 hasConcept C8243546 @default.
- W2884782017 hasConcept C86803240 @default.
- W2884782017 hasConceptScore W2884782017C203014093 @default.
- W2884782017 hasConceptScore W2884782017C2522874641 @default.
- W2884782017 hasConceptScore W2884782017C2776408679 @default.
- W2884782017 hasConceptScore W2884782017C2778163477 @default.
- W2884782017 hasConceptScore W2884782017C2780072125 @default.
- W2884782017 hasConceptScore W2884782017C4733338 @default.
- W2884782017 hasConceptScore W2884782017C49039625 @default.
- W2884782017 hasConceptScore W2884782017C55493867 @default.
- W2884782017 hasConceptScore W2884782017C8243546 @default.
- W2884782017 hasConceptScore W2884782017C86803240 @default.
- W2884782017 hasIssue "36" @default.
- W2884782017 hasLocation W28847820171 @default.
- W2884782017 hasOpenAccess W2884782017 @default.
- W2884782017 hasPrimaryLocation W28847820171 @default.
- W2884782017 hasRelatedWork W108071359 @default.
- W2884782017 hasRelatedWork W1969454927 @default.
- W2884782017 hasRelatedWork W1976894444 @default.
- W2884782017 hasRelatedWork W2016893082 @default.
- W2884782017 hasRelatedWork W2082385872 @default.
- W2884782017 hasRelatedWork W2128821411 @default.
- W2884782017 hasRelatedWork W2165493519 @default.
- W2884782017 hasRelatedWork W2295433043 @default.
- W2884782017 hasRelatedWork W2384465757 @default.
- W2884782017 hasRelatedWork W2417579059 @default.
- W2884782017 hasRelatedWork W2530314574 @default.
- W2884782017 hasRelatedWork W2609297799 @default.
- W2884782017 hasRelatedWork W2620861705 @default.
- W2884782017 hasRelatedWork W2763598169 @default.
- W2884782017 hasRelatedWork W3005694982 @default.
- W2884782017 hasRelatedWork W3048774260 @default.
- W2884782017 hasRelatedWork W3097133327 @default.
- W2884782017 hasRelatedWork W3159967698 @default.
- W2884782017 hasRelatedWork W3203036656 @default.
- W2884782017 hasRelatedWork W609654621 @default.
- W2884782017 isParatext "false" @default.
- W2884782017 isRetracted "false" @default.
- W2884782017 magId "2884782017" @default.
- W2884782017 workType "article" @default.