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- W2884792170 abstract "Background: Infection is a major contributor to morbidity and mortality in sickle cell disease (SCD). Together with hygiene and antibiotics, vaccination led to the elimination of many childhood infectious diseases and contributed to the increase in disability-free life expectancy that in Western societies rose from 50 to 78-85 years. Though it has been shown that individuals with sickle cell disease (SCD) are more susceptible to Salmonella infection, Salmonella vaccine is not included in the routine vaccination schedule for children in Nigeria. The objective of this study therefore is to determine the prevalence of Salmonella infections in SCD children compared to non-SCD children in Abuja with the aim of advocating for the inclusion of Salmonella vaccine to the routine immunization schedule of Nigerian children, especially children with sickle cell disease Methods & Materials: A retrospective study of children enrolled into the Community Acquired Bacteremia among Young Nigerian Children Research(CABSYNC) over a 6 year period was done to determine the Salmonella isolates implicated in bacteremia of sickle cell disease (SCD). Blood culture and sickle cell screening results of a total of 5435 children aged 5 years and below were analyzed. Results: Of the 5435 children, a total number of 370 positive blood cultures were reported, giving a 6.7% prevalence rate of bacteraemia, while 253 cases were SCD, giving a SCD prevalence rate of 4.7%. Of the 370 positive blood cultures, the frequencies of isolates are Salmonella Typhi (121, 32.7%), Non-Typhoidal Salmonella (42, 11.4%), Staphylococcus aureus (31, 8.4%), Pseudomonas spp (24, 6.5%), Streptococcus pneumoniae (17, 4.6%) and Enterococcus faecalis (20, 5.4%). Out of the 253 SCD cases, 16(6.3%) had positive blood cultures, out of which 7(43.8%) were Salmonella Typhi, 5(31.3%) were Non-Typhoidal Salmonella, 2(12.5%) were Enterobacter spp, 1(6.3%) was Streptococcus pneumoniae and 1(6.3%) was non-haemolytic streptococcus. Chi-square test revealed a statistically significant higher proportion of Typhoidal Salmonella within the SCD group compared to the non-SCD group (OR 2.804, p = 0.0613). Conclusion: The result of this study shows that Salmonella is an implicated organism in bacteraemia among children with SCD, hence the need to include Salmonella vaccine into the routine immunization schedule for Nigerian children" @default.
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- W2884792170 date "2018-08-01" @default.
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- W2884792170 title "A retrospective survey of bacteraemia and advocacy for routine Salmonella immunization in children with sickle cell disease in north central Nigeria" @default.
- W2884792170 doi "https://doi.org/10.1016/j.ijid.2018.04.3655" @default.
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