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- W2884815033 abstract "Ticlopidine inhibits platelet function ex-vivo and prolongs the bleeding time. We investigated its antithrombotic potential in patients with extensive peripheral vascular disease by measurement of survival of Na51Cr- labelled platelets before and following two months treatment with ticlopidine, 250mg twice daily. Platelet survival in six patients with aortic Dacron prostheses and one who had undergone aorto-iliac endarterectomy was 8.04 ± 0.14 days (mean ± SEM) calculated by linear regression and 7.08 ± 0.7l days by gamma function analysis. This is considerably shorter than the mean normal value of 9.98 ± 0.22 days for platelet life-span established in 40 normal subjects by the aspi rin-labelling technique, which correlates very closely with survival time of Na5lCr- labelled platelets in patients. During the eighth week of treatment with ticlopidine measurement of survival of Na5l Cr-labelled platelets was repeated. Mean platelet survival was not affected by ticlopidine treatment, with survival times of 8.12 ± 0.24 days by linear regression and 7.0 ± 0.54 days by gamma function analysis. Tablet counts indicated that patients complied with the treatment regime and single random blood sampling indicated that adequate plasma concentrations of ticlopidine were attained. It is concluded that ticlopidine 250mg twice daily does not prolong shortened platelet survival in patients with Dacron prostheses." @default.
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- W2884815033 date "1981-01-01" @default.
- W2884815033 modified "2023-09-27" @default.
- W2884815033 title "Platelet Survival In Patients With Aortic Dacron Prostheses Treated With Ticlopidine" @default.
- W2884815033 doi "https://doi.org/10.1055/s-0038-1652862" @default.
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