Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884826785> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2884826785 endingPage "1483" @default.
- W2884826785 startingPage "1478" @default.
- W2884826785 abstract "The evolutionary conserved genomic sequences that have acquired significantly increased number of nucleotide substitutions specifically in the human lineage, called human accelerated regions (HARs), have been identified as candidate genomic regions that have contributed to the evolution of human-specific traits. A number of HARs were indeed shown to have novel enhancer activity and be associated with human-specific brain development and with cognition and social behavior. It is therefore of great importance to investigate the details of genomic function of each HAR to understand the roles of HARs as critical contributors to the genetic basis of human evolution. In this study, we identified a previously unannotated brain-expressed noncoding RNA gene, HSTR1, at a human-specific tandem repeat locus. Notably, the 5' flanking sequence of HSTR1 showed the signature of HARs and the dramatic human-specific enhancement of promoter activity, providing the evidence of positive selection to increase the expression level of HSTR1 during human evolution. We also revealed that the tandem repeat number in HSTR1 was highly variable among individual alleles and affected the stability of HSTR1 RNA, suggesting variation in the activity of HSTR1 between human individuals. Our work thus provides a novel candidate gene that potentially contributed to the evolution of the human brain. It may also underpin some of the variation between human brains." @default.
- W2884826785 created "2018-08-03" @default.
- W2884826785 creator A5015936580 @default.
- W2884826785 creator A5039059746 @default.
- W2884826785 creator A5076546588 @default.
- W2884826785 date "2018-09-01" @default.
- W2884826785 modified "2023-09-24" @default.
- W2884826785 title "Novel brain-expressed noncoding RNA, HSTR1, identified at a human-specific variable number tandem repeat locus with a human accelerated region" @default.
- W2884826785 cites W1689369637 @default.
- W2884826785 cites W1977294183 @default.
- W2884826785 cites W1978083828 @default.
- W2884826785 cites W1983130040 @default.
- W2884826785 cites W2024439539 @default.
- W2884826785 cites W2048128721 @default.
- W2884826785 cites W2060256600 @default.
- W2884826785 cites W2085384621 @default.
- W2884826785 cites W2086514583 @default.
- W2884826785 cites W2089340258 @default.
- W2884826785 cites W2098573707 @default.
- W2884826785 cites W2102702746 @default.
- W2884826785 cites W2102773855 @default.
- W2884826785 cites W2115435518 @default.
- W2884826785 cites W2127608175 @default.
- W2884826785 cites W2128969076 @default.
- W2884826785 cites W2133663604 @default.
- W2884826785 cites W2142331601 @default.
- W2884826785 cites W2146120203 @default.
- W2884826785 cites W2152156139 @default.
- W2884826785 cites W2210213181 @default.
- W2884826785 cites W2460597599 @default.
- W2884826785 cites W2516461792 @default.
- W2884826785 cites W2522953732 @default.
- W2884826785 cites W2770441915 @default.
- W2884826785 doi "https://doi.org/10.1016/j.bbrc.2018.07.066" @default.
- W2884826785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30029879" @default.
- W2884826785 hasPublicationYear "2018" @default.
- W2884826785 type Work @default.
- W2884826785 sameAs 2884826785 @default.
- W2884826785 citedByCount "2" @default.
- W2884826785 countsByYear W28848267852019 @default.
- W2884826785 countsByYear W28848267852023 @default.
- W2884826785 crossrefType "journal-article" @default.
- W2884826785 hasAuthorship W2884826785A5015936580 @default.
- W2884826785 hasAuthorship W2884826785A5039059746 @default.
- W2884826785 hasAuthorship W2884826785A5076546588 @default.
- W2884826785 hasConcept C104317684 @default.
- W2884826785 hasConcept C111936080 @default.
- W2884826785 hasConcept C141231307 @default.
- W2884826785 hasConcept C150194340 @default.
- W2884826785 hasConcept C169760540 @default.
- W2884826785 hasConcept C27149982 @default.
- W2884826785 hasConcept C2777670902 @default.
- W2884826785 hasConcept C54355233 @default.
- W2884826785 hasConcept C70721500 @default.
- W2884826785 hasConcept C78458016 @default.
- W2884826785 hasConcept C84597430 @default.
- W2884826785 hasConcept C86803240 @default.
- W2884826785 hasConceptScore W2884826785C104317684 @default.
- W2884826785 hasConceptScore W2884826785C111936080 @default.
- W2884826785 hasConceptScore W2884826785C141231307 @default.
- W2884826785 hasConceptScore W2884826785C150194340 @default.
- W2884826785 hasConceptScore W2884826785C169760540 @default.
- W2884826785 hasConceptScore W2884826785C27149982 @default.
- W2884826785 hasConceptScore W2884826785C2777670902 @default.
- W2884826785 hasConceptScore W2884826785C54355233 @default.
- W2884826785 hasConceptScore W2884826785C70721500 @default.
- W2884826785 hasConceptScore W2884826785C78458016 @default.
- W2884826785 hasConceptScore W2884826785C84597430 @default.
- W2884826785 hasConceptScore W2884826785C86803240 @default.
- W2884826785 hasFunder F4320320912 @default.
- W2884826785 hasIssue "3" @default.
- W2884826785 hasLocation W28848267851 @default.
- W2884826785 hasLocation W28848267852 @default.
- W2884826785 hasOpenAccess W2884826785 @default.
- W2884826785 hasPrimaryLocation W28848267851 @default.
- W2884826785 hasRelatedWork W1886625688 @default.
- W2884826785 hasRelatedWork W2020838698 @default.
- W2884826785 hasRelatedWork W2028087115 @default.
- W2884826785 hasRelatedWork W2074557265 @default.
- W2884826785 hasRelatedWork W2082080217 @default.
- W2884826785 hasRelatedWork W2104498991 @default.
- W2884826785 hasRelatedWork W2465559157 @default.
- W2884826785 hasRelatedWork W4233150668 @default.
- W2884826785 hasRelatedWork W4233699406 @default.
- W2884826785 hasRelatedWork W64331312 @default.
- W2884826785 hasVolume "503" @default.
- W2884826785 isParatext "false" @default.
- W2884826785 isRetracted "false" @default.
- W2884826785 magId "2884826785" @default.
- W2884826785 workType "article" @default.