FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884837163> ?p ?o ?g. }

• W2884837163 endingPage "1657" @default.
• W2884837163 startingPage "1647" @default.
• W2884837163 abstract "Muscle changes of critical illness are attributed to systemic inflammatory responses and disuse atrophy. GTS-21 (3-(2,4-dimethoxy-benzylidene)anabaseine), also known as DMBX-A) is a synthetic derivative of the natural product anabaseine that acts as an agonist at α7-acetylcholine receptors (α7nAChRs). Hypothesis tested was that modulation of inflammation by agonist GTS-21 (10 mg/kg b.i.d. intraperitoneally) will attenuate body weight (BW) and muscle changes. Systemic sham inflammation was produced in 125 rats by Cornyebacterium parvum (C.p.) or saline injection on days 0/4/8. Seventy-four rats had one immobilized-limb producing disuse atrophy. GTS-21 effects on BW, tibialis muscle mass (TMM), and function were assessed on day 12. Systemically, methemoglobin levels increased 26-fold with C.p. (p < 0.001) and decreased significantly (p < 0.033) with GTS-21. Control BW increased (+ 30 ± 9 g, mean ± SD) at day 12, but decreased with C.p. and superimposed disuse (p = 0.005). GTS-21 attenuated BW loss in C.p. (p = 0.005). Compared to controls, TMM decreased with C.p. (0.43 ± 0.06 g to 0.26 ± 0.03 g) and with superimposed disuse (0.18 ± 0.04 g); GTS-21 ameliorated TMM loss to 0.32 ± 0.04 (no disuse, p = 0.028) and to 0.22 ± 0.03 (with disuse, p = 0.004). Tetanic tensions decreased with C.p. or disuse and GTS-21 attenuated tension decrease in animals with disuse (p = 0.006) and in animals with C.p. and disuse (p = 0.029). C.p.-induced 11-fold increased muscle α7nAChR expression was decreased by > 60% with GTS-21 treatment. In conclusion, GTS-21 modulates systemic inflammation, evidenced by both decreased methemoglobin levels and decrease of α7nAChR expression, and mitigates inflammation-mediated loss of BW, TMM, fiber size, and function." @default.
• W2884837163 created "2018-08-03" @default.
• W2884837163 creator A5004025632 @default.
• W2884837163 creator A5008948855 @default.
• W2884837163 creator A5010644716 @default.
• W2884837163 creator A5021219312 @default.
• W2884837163 creator A5023563705 @default.
• W2884837163 creator A5024681233 @default.
• W2884837163 creator A5031160333 @default.
• W2884837163 creator A5035143218 @default.
• W2884837163 creator A5062438305 @default.
• W2884837163 creator A5069730232 @default.
• W2884837163 creator A5078398049 @default.
• W2884837163 creator A5088628229 @default.
• W2884837163 date "2018-07-13" @default.
• W2884837163 modified "2023-10-11" @default.
• W2884837163 title "GTS-21 attenuates loss of body mass, muscle mass, and function in rats having systemic inflammation with and without disuse atrophy" @default.
• W2884837163 cites W1845178728 @default.
• W2884837163 cites W1964493140 @default.
• W2884837163 cites W1967635792 @default.
• W2884837163 cites W1973078413 @default.
• W2884837163 cites W1973684890 @default.
• W2884837163 cites W1974318049 @default.
• W2884837163 cites W1978492957 @default.
• W2884837163 cites W1978923001 @default.
• W2884837163 cites W1985918099 @default.
• W2884837163 cites W1989139348 @default.
• W2884837163 cites W1991980674 @default.
• W2884837163 cites W1993879746 @default.
• W2884837163 cites W1994684670 @default.
• W2884837163 cites W1995846564 @default.
• W2884837163 cites W1996668514 @default.
• W2884837163 cites W1999693191 @default.
• W2884837163 cites W2026008603 @default.
• W2884837163 cites W2026809945 @default.
• W2884837163 cites W2027206507 @default.
• W2884837163 cites W2029479929 @default.
• W2884837163 cites W2042411481 @default.
• W2884837163 cites W2044214453 @default.
• W2884837163 cites W2044886197 @default.
• W2884837163 cites W2046437271 @default.
• W2884837163 cites W2048977247 @default.
• W2884837163 cites W2050700956 @default.
• W2884837163 cites W2054428671 @default.
• W2884837163 cites W2058039595 @default.
• W2884837163 cites W2076809595 @default.
• W2884837163 cites W2079936287 @default.
• W2884837163 cites W2087483514 @default.
• W2884837163 cites W2093731835 @default.
• W2884837163 cites W2100580040 @default.
• W2884837163 cites W2102891554 @default.
• W2884837163 cites W2109005423 @default.
• W2884837163 cites W2111861407 @default.
• W2884837163 cites W2112079434 @default.
• W2884837163 cites W2117567032 @default.
• W2884837163 cites W2118240638 @default.
• W2884837163 cites W2120431726 @default.
• W2884837163 cites W2124533302 @default.
• W2884837163 cites W2131699531 @default.
• W2884837163 cites W2133764408 @default.
• W2884837163 cites W2138394833 @default.
• W2884837163 cites W2139641232 @default.
• W2884837163 cites W2146346947 @default.
• W2884837163 cites W2149189574 @default.
• W2884837163 cites W2150091209 @default.
• W2884837163 cites W2152263844 @default.
• W2884837163 cites W2156291518 @default.
• W2884837163 cites W2159075977 @default.
• W2884837163 cites W2159545287 @default.
• W2884837163 cites W2161096914 @default.
• W2884837163 cites W2163204104 @default.
• W2884837163 cites W2171775725 @default.
• W2884837163 cites W2326121756 @default.
• W2884837163 cites W2331809063 @default.
• W2884837163 cites W2396986249 @default.
• W2884837163 cites W2404360023 @default.
• W2884837163 cites W2517976315 @default.
• W2884837163 cites W2518330583 @default.
• W2884837163 cites W2525291310 @default.
• W2884837163 cites W2593556902 @default.
• W2884837163 cites W2747130438 @default.
• W2884837163 cites W2783888699 @default.
• W2884837163 cites W4231838896 @default.
• W2884837163 cites W4234642177 @default.
• W2884837163 cites W4251677055 @default.
• W2884837163 doi "https://doi.org/10.1007/s00424-018-2180-6" @default.
• W2884837163 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6330254" @default.
• W2884837163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30006848" @default.
• W2884837163 hasPublicationYear "2018" @default.
• W2884837163 type Work @default.
• W2884837163 sameAs 2884837163 @default.
• W2884837163 citedByCount "11" @default.
• W2884837163 countsByYear W28848371632019 @default.
• W2884837163 countsByYear W28848371632020 @default.
• W2884837163 countsByYear W28848371632021 @default.
• W2884837163 countsByYear W28848371632022 @default.
• W2884837163 countsByYear W28848371632023 @default.
• W2884837163 crossrefType "journal-article" @default.

• next