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- W2884844055 abstract "Two novel platinum(ii) complexes, [PtCl2(H-MeOBC)(DMSO)] (Pt1) and [Pt2Cl3(MeOBC)(DMSO)2] (Pt2), with 3-(2'-benzimidazolyl)-8-methoxycoumarin (H-MeOBC) as the ligand were synthesized and evaluated for their antiproliferative activity. Among all the tumor cells, dual-Pt(ii) complex Pt2 exhibited the most potent activity, with an IC50 value of 0.5 ± 0.2 μM against cisplatin-resistant SK-OV-3/DDP cancer cells. In the case of SK-OV-3/DDP cells, Pt2 displayed a 20.1-196.0-fold increased activity when compared with cisplatin, H-MeOBC and Pt1. Importantly, Pt1 and Pt2 displayed low inhibitory rates against normal HL-7702 cells. Further investigation revealed that Pt2 is a novel telomerase inhibitor binding to c-myc promoter elements. Mechanistic studies demonstrated that dual-Pt(ii) complex Pt2 arrests the cell cycle at the G2/M phase and induces apoptosis and causes mitochondrial dysfunction." @default.
- W2884844055 created "2018-08-03" @default.
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- W2884844055 date "2018-01-01" @default.
- W2884844055 modified "2023-10-14" @default.
- W2884844055 title "Synthesis and antitumor mechanisms of two novel platinum(<scp>ii</scp>) complexes with 3-(2′-benzimidazolyl)-7-methoxycoumarin" @default.
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- W2884844055 cites W1979521450 @default.
- W2884844055 cites W1982339020 @default.
- W2884844055 cites W1982859999 @default.
- W2884844055 cites W1983111514 @default.
- W2884844055 cites W1984196191 @default.
- W2884844055 cites W1988376335 @default.
- W2884844055 cites W1993394468 @default.
- W2884844055 cites W1996868772 @default.
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- W2884844055 cites W2002404925 @default.
- W2884844055 cites W2002905732 @default.
- W2884844055 cites W2008006215 @default.
- W2884844055 cites W2010617308 @default.
- W2884844055 cites W2015591824 @default.
- W2884844055 cites W2016730049 @default.
- W2884844055 cites W2017588171 @default.
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- W2884844055 doi "https://doi.org/10.1039/c8mt00125a" @default.
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