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• W2884860421 abstract "Pressure overload-induced myocardial hypertrophy is a key step leading to heart failure. Previous cellular and animal studies demonstrated that deteriorated excitation-contraction coupling occurs as early as the compensated stage of hypertrophy before the global decrease in left ventricular ejection fraction (LVEF). This study was to evaluate the cardiac electromechanical coupling time in evaluating cardiac systolic function in the early stage of heart failure.Twenty-six patients with Stage B heart failure (SBHF) and 31 healthy controls (CONs) were enrolled in this study. M-mode echocardiography was performed to measure LVEF. Tissue Doppler imaging (TDI) combined with electrocardiography (ECG) was used to measure cardiac electromechanical coupling time.There was no significant difference in LVEF between SBHF patients and CONs (64.23 ± 8.91% vs. 64.52 ± 5.90%; P = 0.886). However, all four electromechanical coupling time courses (Qsb: onset of Q wave on ECG to beginning of S wave on TDI, Qst: onset of Q wave on ECG to top of S wave on TDI, Rsb: top of R wave on ECG to beginning of S wave on TDI, and Rst: top of R wave on ECG to top of S wave on TDI) of SBHF patients were significantly longer than those of CONs (Qsb: 119.19 ± 35.68 ms vs. 80.30 ± 14.81 ms, P < 0.001; Qst: 165.42 ± 60.93 ms vs. 129.04 ± 16.97 ms, P = 0.006; Rsb: 82.43 ± 33.66 ms vs. 48.30 ± 15.18 ms, P < 0.001; and Rst: 122.37 ± 36.66 ms vs. 93.25 ± 16.72 ms, P = 0.001), and the Qsb, Rsb, and Rst time showed a significantly higher sensitivity than LVEF (Rst: P =0.032; Rsb: P = 0.003; and Qsb: P = 0.004).The cardiac electromechanical coupling time is more sensitive than LVEF in evaluating cardiac systolic function.心肌电-机械耦联参数评价心脏收缩功能的优越性摘要背景：压力负荷引起的心肌肥厚是引起心力衰竭的重要因素之一，前期的细胞实验和动物实验表明在心脏收缩功能（左心室射血分数）下降之前，心肌细胞兴奋-收缩耦联效率已经发生下降。本研究的目的是为检测心肌电-机械耦联参数在心力衰竭早期对心脏收缩功能的评价作用。 方法：26名心力衰竭B期患者和31名健康志愿者纳入此研究中，使用M型超声心动图测量左心室射血分数（LVEF），超声心动图组织多普勒联合心电图用于测量心肌的电-机械耦联参数。 结果：与健康志愿者相比，心力衰竭B期患者的LVEF值未显著降低（64.23±8.91 vs. 64.52±5.90 %; P=0.886）。然而，心力衰竭B期患者心肌电-机械耦联参数均明显延长（Qsb：心电图Q波的波谷至组织多普勒S波起点的时间；Qst：心电图Q波的波谷至组织多普勒S波波峰的时间；Rsb：心电图R波的波峰至组织多普勒S波起点的时间；Rst：心电图上R波的波峰至组织多普勒上S波波峰的时间）（Qsb: 119.19 ± 35.68 vs. 80.30 ±14.81 ms, P<0.001; Qst: 165.42 ± 60.93 vs. 129.04 ± 16.97 ms, P=0.006; Rsb: 82.43 ± 33.66 vs. 48.30 ±15.18 ms, P<0.001; Rst: 122.37 ±36.66 vs. 93.25 ± 16.72 ms, P=0.001）。此外，Qsb，Rsb与Rst 的敏感性明显高于LVEF（Rst: P=0.032; Rsb: P=0.003; Qsb: P=0.004）。 结论：研究结果显示心肌电-机械耦联参数在评价心脏收缩功能方面比LVEF更加敏感。." @default.
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• W2884860421 date "2018-08-05" @default.
• W2884860421 modified "2023-09-27" @default.
• W2884860421 title "Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function" @default.
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• W2884860421 doi "https://doi.org/10.4103/0366-6999.237395" @default.
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