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• W2884869981 abstract "Amyloid precursor-like protein 2 (APLP2) belongs to the APP family and is widely expressed in human cells. Though previous studies have suggested a role of APLP2 in cancer progression, the exact role of APLP2 in cell migration remains elusive. Here in this report, we show that ectopic expression of APLP2 in Drosophila induces cell migration which is mediated by JNK signaling, as loss of JNK suppresses while gain of JNK enhances such phenotype. APLP2 is able to activate JNK signaling by phosphorylation of JNK, which triggers the expression of matrix metalloproteinase MMP1 required for basement membranes degradation to promote cell migration. The data presented here unraveled an in vivo role of APLP2 in JNK-mediated cell migration." @default.
• W2884869981 created "2018-08-03" @default.
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• W2884869981 date "2018-07-29" @default.
• W2884869981 modified "2023-10-16" @default.
• W2884869981 title "APLP2 Modulates JNK-Dependent Cell Migration inDrosophila" @default.
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• W2884869981 doi "https://doi.org/10.1155/2018/7469714" @default.
• W2884869981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6093063" @default.
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