Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884893268> ?p ?o ?g. }
- W2884893268 abstract "Heroin and methamphetamine (METH) addiction continues to be a major social, economic and therapeutic problem worldwide. The opioid pathway may mediate the effects of addictive drugs. However, the potential correlation between the κ1 opioid receptor (OPRK1) and drug addiction has not yet been characterized. The aim of the present study was to investigate the potential association between methylation of the OPRK1 promoter and substance abuse. Bisulfite pyrosequencing technology was used to determine the levels of OPRK1 promoter methylation in 60 drug abusers (30 heroin and 30 METH addicts) and 52 controls, observed to exhibit no significant differences in age or gender. The results indicated that levels of OPRK1 promoter methylation were significantly higher in drug addicts when compared with controls (P=2.43×10-4). Significant correlations between OPRK1 promoter methylation and the length and frequency of drug use were also observed in male heroin addicts (length: r=0.661, P=0.007; frequency: r=-0.684, P=0.005). In addition, a luciferase reporter gene assay indicated that the OPRK1 promoter fragment was able to regulate gene expression (fold change between two groups >32.12, P≤0.0001). In conclusion, results of the present study indicate that methylation of the OPRK1 promoter contributes to the pathophysiology of drug addiction." @default.
- W2884893268 created "2018-08-03" @default.
- W2884893268 creator A5001736408 @default.
- W2884893268 creator A5010496598 @default.
- W2884893268 creator A5015696308 @default.
- W2884893268 creator A5021249077 @default.
- W2884893268 creator A5036880568 @default.
- W2884893268 creator A5039707366 @default.
- W2884893268 creator A5040168179 @default.
- W2884893268 creator A5041746925 @default.
- W2884893268 creator A5050624639 @default.
- W2884893268 creator A5069323238 @default.
- W2884893268 creator A5072566128 @default.
- W2884893268 creator A5075309717 @default.
- W2884893268 creator A5087279766 @default.
- W2884893268 creator A5091394665 @default.
- W2884893268 date "2018-07-24" @default.
- W2884893268 modified "2023-10-04" @default.
- W2884893268 title "Hypermethylation of the κ1 opioid receptor promoter in Chinese heroin and methamphetamine addicts" @default.
- W2884893268 cites W1532642006 @default.
- W2884893268 cites W1580690188 @default.
- W2884893268 cites W1628711327 @default.
- W2884893268 cites W1889346063 @default.
- W2884893268 cites W1981899418 @default.
- W2884893268 cites W1987557775 @default.
- W2884893268 cites W2008774977 @default.
- W2884893268 cites W2019658517 @default.
- W2884893268 cites W2021363900 @default.
- W2884893268 cites W2022056804 @default.
- W2884893268 cites W2028704685 @default.
- W2884893268 cites W2029741050 @default.
- W2884893268 cites W2036139330 @default.
- W2884893268 cites W2043286371 @default.
- W2884893268 cites W2048921553 @default.
- W2884893268 cites W2052464626 @default.
- W2884893268 cites W2053931216 @default.
- W2884893268 cites W2073587729 @default.
- W2884893268 cites W2075527287 @default.
- W2884893268 cites W2077604930 @default.
- W2884893268 cites W2077730361 @default.
- W2884893268 cites W2083332683 @default.
- W2884893268 cites W2085756064 @default.
- W2884893268 cites W2092045635 @default.
- W2884893268 cites W2094815969 @default.
- W2884893268 cites W2099431078 @default.
- W2884893268 cites W2123559913 @default.
- W2884893268 cites W2129572819 @default.
- W2884893268 cites W2134515607 @default.
- W2884893268 cites W2155182235 @default.
- W2884893268 cites W2156165398 @default.
- W2884893268 cites W2293639438 @default.
- W2884893268 cites W2306402428 @default.
- W2884893268 cites W2329351433 @default.
- W2884893268 cites W904184522 @default.
- W2884893268 cites W952127240 @default.
- W2884893268 doi "https://doi.org/10.3892/etm.2018.6514" @default.
- W2884893268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6122531" @default.
- W2884893268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30210591" @default.
- W2884893268 hasPublicationYear "2018" @default.
- W2884893268 type Work @default.
- W2884893268 sameAs 2884893268 @default.
- W2884893268 citedByCount "2" @default.
- W2884893268 countsByYear W28848932682021 @default.
- W2884893268 countsByYear W28848932682023 @default.
- W2884893268 crossrefType "journal-article" @default.
- W2884893268 hasAuthorship W2884893268A5001736408 @default.
- W2884893268 hasAuthorship W2884893268A5010496598 @default.
- W2884893268 hasAuthorship W2884893268A5015696308 @default.
- W2884893268 hasAuthorship W2884893268A5021249077 @default.
- W2884893268 hasAuthorship W2884893268A5036880568 @default.
- W2884893268 hasAuthorship W2884893268A5039707366 @default.
- W2884893268 hasAuthorship W2884893268A5040168179 @default.
- W2884893268 hasAuthorship W2884893268A5041746925 @default.
- W2884893268 hasAuthorship W2884893268A5050624639 @default.
- W2884893268 hasAuthorship W2884893268A5069323238 @default.
- W2884893268 hasAuthorship W2884893268A5072566128 @default.
- W2884893268 hasAuthorship W2884893268A5075309717 @default.
- W2884893268 hasAuthorship W2884893268A5087279766 @default.
- W2884893268 hasAuthorship W2884893268A5091394665 @default.
- W2884893268 hasBestOaLocation W28848932681 @default.
- W2884893268 hasConcept C101762097 @default.
- W2884893268 hasConcept C104317684 @default.
- W2884893268 hasConcept C118552586 @default.
- W2884893268 hasConcept C126322002 @default.
- W2884893268 hasConcept C150194340 @default.
- W2884893268 hasConcept C170493617 @default.
- W2884893268 hasConcept C190727270 @default.
- W2884893268 hasConcept C2778903686 @default.
- W2884893268 hasConcept C2780035454 @default.
- W2884893268 hasConcept C2780376393 @default.
- W2884893268 hasConcept C2781063702 @default.
- W2884893268 hasConcept C33288867 @default.
- W2884893268 hasConcept C48856860 @default.
- W2884893268 hasConcept C54355233 @default.
- W2884893268 hasConcept C71924100 @default.
- W2884893268 hasConcept C86803240 @default.
- W2884893268 hasConcept C98274493 @default.
- W2884893268 hasConceptScore W2884893268C101762097 @default.
- W2884893268 hasConceptScore W2884893268C104317684 @default.
- W2884893268 hasConceptScore W2884893268C118552586 @default.