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- W2884901910 abstract "Malignant mesothelioma (MM), a rare and severe cancer, mainly caused as a result of past-asbestos exposure, is presently a public health concern. Current molecular studies aim to improve the outcome of the disease, providing efficient therapies based on the principles of precision medicine. To model the molecular profile of human malignant mesothelioma, animal models have been developed in rodents, wild type animals and genetically engineered mice harbouring mutations in tumour suppressor genes, especially selecting genes known to be inactivated in human malignant mesothelioma. Animals were either exposed or not exposed to asbestos or to other carcinogenic fibres, to understand the mechanism of action of fibres at the molecular level, and the role of the selected genes in mesothelial carcinogenesis. The aim of the manuscript was to compare mesothelioma models to human malignant mesothelioma and to specify the clue genes playing a role in mesothelial carcinogenesis. Collectively, MM models recapitulate the clinical features of human MM. At least two altered genes are needed to induce malignant mesothelioma in mice. Two pathways regulated by Cdkn2a and Trp53 seem independent key players in mesothelial carcinogenesis. Other genes and pathways appear as bona fide modulators of the neoplastic transformation." @default.
- W2884901910 created "2018-08-03" @default.
- W2884901910 creator A5088709075 @default.
- W2884901910 creator A5089268107 @default.
- W2884901910 date "2018-07-27" @default.
- W2884901910 modified "2023-10-16" @default.
- W2884901910 title "Mesotheliomas in Genetically Engineered Mice Unravel Mechanism of Mesothelial Carcinogenesis" @default.
- W2884901910 cites W102573316 @default.
- W2884901910 cites W1517688143 @default.
- W2884901910 cites W1558724718 @default.
- W2884901910 cites W1964389584 @default.
- W2884901910 cites W1966625054 @default.
- W2884901910 cites W1977727861 @default.
- W2884901910 cites W1977849264 @default.
- W2884901910 cites W1978135247 @default.
- W2884901910 cites W1988829860 @default.
- W2884901910 cites W1998543226 @default.
- W2884901910 cites W1998966516 @default.
- W2884901910 cites W2011047576 @default.
- W2884901910 cites W2016343650 @default.
- W2884901910 cites W2021820791 @default.
- W2884901910 cites W2025730393 @default.
- W2884901910 cites W2030813809 @default.
- W2884901910 cites W2039272485 @default.
- W2884901910 cites W2042328755 @default.
- W2884901910 cites W2045720834 @default.
- W2884901910 cites W2048241935 @default.
- W2884901910 cites W2050426104 @default.
- W2884901910 cites W2060355103 @default.
- W2884901910 cites W2067423716 @default.
- W2884901910 cites W2070736508 @default.
- W2884901910 cites W2071734901 @default.
- W2884901910 cites W2094769871 @default.
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- W2884901910 cites W2105905382 @default.
- W2884901910 cites W2115758341 @default.
- W2884901910 cites W2118880233 @default.
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- W2884901910 cites W2124555630 @default.
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- W2884901910 cites W2161488572 @default.
- W2884901910 cites W2161622567 @default.
- W2884901910 cites W2162193607 @default.
- W2884901910 cites W2184726952 @default.
- W2884901910 cites W2221814429 @default.
- W2884901910 cites W2266849806 @default.
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- W2884901910 cites W2418665003 @default.
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- W2884901910 doi "https://doi.org/10.3390/ijms19082191" @default.
- W2884901910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6121615" @default.
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- W2884901910 hasPublicationYear "2018" @default.
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