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- W2884905658 abstract "Abstract Despite recent improvement in short-term outcome following ST-elevation myocardial infarction, long-term outcome remains challenged by increased post-infarction mortality and morbidity predominantly caused by heart failure. Coronary microvascular obstruction and intramyocardial hemorrhage, compromising coronary microvascular function, are important determinants of short- and long-term outcome following reperfusion therapy of acute myocardial infarction but specific therapy is not established. Identification of patients with adverse outcome related to coronary microvascular dysfunction is possible by cardiac magnetic resonance imaging. Risk factor modification and guideline-based anticongestive therapy including complete revascularization are evidence-based therapies that may delay disease progression of post-infarction heart failure, while heart transplantation remains the only treatment for end-stage failure. Long-term remote ischemic conditioning, stem cell transplantation and stem cell-derived exosome therapy mediating the paracrine mechanisms underlying stem cell-based therapy may be potential treatments addressing repair and regeneration of the damaged myocardium in the future treatment of post-infarction heart failure." @default.
- W2884905658 created "2018-08-03" @default.
- W2884905658 creator A5001353746 @default.
- W2884905658 date "2018-01-01" @default.
- W2884905658 modified "2023-10-17" @default.
- W2884905658 title "Long-Term Management After Coronary Microvascular Obstruction Complicating Reperfusion in ST-Elevation Myocardial Infarction" @default.
- W2884905658 doi "https://doi.org/10.1016/b978-0-12-812528-1.00020-8" @default.
- W2884905658 hasPublicationYear "2018" @default.
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