Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884919562> ?p ?o ?g. }
- W2884919562 endingPage "2173" @default.
- W2884919562 startingPage "2173" @default.
- W2884919562 abstract "Spontaneous beating of the heart pacemaker, the sinoatrial node, is generated by sinoatrial node cells (SANC) and caused by gradual change of the membrane potential called diastolic depolarization (DD). Submembrane local Ca2+ releases (LCR) from sarcoplasmic reticulum (SR) occur during late DD and activate an inward Na+/Ca2+ exchange current, which accelerates the DD rate leading to earlier occurrence of an action potential. A comparison of intrinsic SR Ca2+ cycling revealed that, at similar physiological Ca2+ concentrations, LCRs are large and rhythmic in permeabilized SANC, but small and random in permeabilized ventricular myocytes (VM). Permeabilized SANC spontaneously released more Ca2+ from SR than VM, despite comparable SR Ca2+ content in both cell types. In this review we discuss specific patterns of expression and distribution of SR Ca2+ cycling proteins (SR Ca2+ ATPase (SERCA2), phospholamban (PLB) and ryanodine receptors (RyR)) in SANC and ventricular myocytes. We link ability of SANC to generate larger and rhythmic LCRs with increased abundance of SERCA2, reduced abundance of the SERCA inhibitor PLB. In addition, an increase in intracellular [Ca2+] increases phosphorylation of both PLB and RyR exclusively in SANC. The differences in SR Ca2+ cycling protein expression between SANC and VM provide insights into diverse regulation of intrinsic SR Ca2+ cycling that drives automaticity of SANC." @default.
- W2884919562 created "2018-08-03" @default.
- W2884919562 creator A5048711709 @default.
- W2884919562 creator A5060742163 @default.
- W2884919562 creator A5075325289 @default.
- W2884919562 date "2018-07-25" @default.
- W2884919562 modified "2023-09-25" @default.
- W2884919562 title "Unique Ca2+-Cycling Protein Abundance and Regulation Sustains Local Ca2+ Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells" @default.
- W2884919562 cites W138609828 @default.
- W2884919562 cites W1479127827 @default.
- W2884919562 cites W1483833346 @default.
- W2884919562 cites W1534028861 @default.
- W2884919562 cites W1567439183 @default.
- W2884919562 cites W1567439646 @default.
- W2884919562 cites W1819240213 @default.
- W2884919562 cites W1841459307 @default.
- W2884919562 cites W1879592195 @default.
- W2884919562 cites W1903925553 @default.
- W2884919562 cites W1963573758 @default.
- W2884919562 cites W1964799458 @default.
- W2884919562 cites W1967688761 @default.
- W2884919562 cites W1969615011 @default.
- W2884919562 cites W1972134881 @default.
- W2884919562 cites W1975928461 @default.
- W2884919562 cites W1975931806 @default.
- W2884919562 cites W1978598122 @default.
- W2884919562 cites W1983128983 @default.
- W2884919562 cites W1983155732 @default.
- W2884919562 cites W1989361508 @default.
- W2884919562 cites W1992290425 @default.
- W2884919562 cites W1992778391 @default.
- W2884919562 cites W1994006752 @default.
- W2884919562 cites W1995536774 @default.
- W2884919562 cites W1996022889 @default.
- W2884919562 cites W1996753588 @default.
- W2884919562 cites W1999242870 @default.
- W2884919562 cites W2001261561 @default.
- W2884919562 cites W2004895216 @default.
- W2884919562 cites W2005062146 @default.
- W2884919562 cites W2006265598 @default.
- W2884919562 cites W2010305640 @default.
- W2884919562 cites W2011038097 @default.
- W2884919562 cites W2012725313 @default.
- W2884919562 cites W2016543067 @default.
- W2884919562 cites W2017348510 @default.
- W2884919562 cites W2017784700 @default.
- W2884919562 cites W2020424651 @default.
- W2884919562 cites W2023470676 @default.
- W2884919562 cites W2023591835 @default.
- W2884919562 cites W2031916898 @default.
- W2884919562 cites W2032602706 @default.
- W2884919562 cites W2032979918 @default.
- W2884919562 cites W2037521168 @default.
- W2884919562 cites W2044145296 @default.
- W2884919562 cites W2044390013 @default.
- W2884919562 cites W2046032102 @default.
- W2884919562 cites W2046077259 @default.
- W2884919562 cites W2047671271 @default.
- W2884919562 cites W2049445457 @default.
- W2884919562 cites W2051048223 @default.
- W2884919562 cites W2052890699 @default.
- W2884919562 cites W2054225000 @default.
- W2884919562 cites W2059509358 @default.
- W2884919562 cites W2062997685 @default.
- W2884919562 cites W2064438064 @default.
- W2884919562 cites W2066089349 @default.
- W2884919562 cites W2070995576 @default.
- W2884919562 cites W2071568942 @default.
- W2884919562 cites W2078317871 @default.
- W2884919562 cites W2080375132 @default.
- W2884919562 cites W2080482562 @default.
- W2884919562 cites W2084584963 @default.
- W2884919562 cites W2084874490 @default.
- W2884919562 cites W2086106297 @default.
- W2884919562 cites W2086678636 @default.
- W2884919562 cites W2091867363 @default.
- W2884919562 cites W2092726461 @default.
- W2884919562 cites W2092836487 @default.
- W2884919562 cites W2093289575 @default.
- W2884919562 cites W2093827572 @default.
- W2884919562 cites W2094821222 @default.
- W2884919562 cites W2096204354 @default.
- W2884919562 cites W2097216911 @default.
- W2884919562 cites W2101822309 @default.
- W2884919562 cites W2104688167 @default.
- W2884919562 cites W2106754238 @default.
- W2884919562 cites W2109285036 @default.
- W2884919562 cites W2110275949 @default.
- W2884919562 cites W2112428065 @default.
- W2884919562 cites W2112483397 @default.
- W2884919562 cites W2112618887 @default.
- W2884919562 cites W2112792367 @default.
- W2884919562 cites W2114135306 @default.
- W2884919562 cites W2114341210 @default.
- W2884919562 cites W2114942701 @default.
- W2884919562 cites W2116297568 @default.
- W2884919562 cites W2116691755 @default.
- W2884919562 cites W2117404190 @default.