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• W2884943463 endingPage "254" @default.
• W2884943463 startingPage "235" @default.
• W2884943463 abstract "The landmark year 1988 can be considered as the birthdate of mitochondrial medicine, when the first pathogenic mutations affecting mtDNA were associated with human diseases. Three decades later, the field still expands and we are not 'scraping the bottom of the barrel' yet. Despite the tremendous progress in terms of molecular characterization and genotype/phenotype correlations, for the vast majority of cases we still lack a deep understanding of the pathogenesis, good models to study, and effective therapeutic options. However, recent technological advances including somatic cell reprogramming to induced pluripotent stem cells (iPSCs), organoid technology, and tailored endonucleases provide unprecedented opportunities to fill these gaps, casting hope to soon cure the major primary mitochondrial phenotypes reviewed here. This group of rare diseases represents a key model for tackling the pathogenic mechanisms involving mitochondrial biology relevant to much more common disorders that affect our currently ageing population, such as diabetes and metabolic syndrome, neurodegenerative and inflammatory disorders, and cancer." @default.
• W2884943463 created "2018-08-03" @default.
• W2884943463 creator A5048398288 @default.
• W2884943463 creator A5070622522 @default.
• W2884943463 date "2018-07-20" @default.
• W2884943463 modified "2023-09-26" @default.
• W2884943463 title "Clinical syndromes associated with mtDNA mutations: where we stand after 30 years" @default.
• W2884943463 cites W1409980657 @default.
• W2884943463 cites W1481562137 @default.
• W2884943463 cites W1484678674 @default.
• W2884943463 cites W1561484646 @default.
• W2884943463 cites W1937825562 @default.
• W2884943463 cites W1964510960 @default.
• W2884943463 cites W1965319690 @default.
• W2884943463 cites W1967496357 @default.
• W2884943463 cites W1968493182 @default.
• W2884943463 cites W1968622987 @default.
• W2884943463 cites W1968940507 @default.
• W2884943463 cites W1970693337 @default.
• W2884943463 cites W1971293741 @default.
• W2884943463 cites W1972140717 @default.
• W2884943463 cites W1976628426 @default.
• W2884943463 cites W1977174816 @default.
• W2884943463 cites W1978476989 @default.
• W2884943463 cites W1979182088 @default.
• W2884943463 cites W1983911032 @default.
• W2884943463 cites W1985391609 @default.
• W2884943463 cites W1986781430 @default.
• W2884943463 cites W1988119513 @default.
• W2884943463 cites W1989083975 @default.
• W2884943463 cites W1992477424 @default.
• W2884943463 cites W1993818941 @default.
• W2884943463 cites W1994286667 @default.
• W2884943463 cites W1994441876 @default.
• W2884943463 cites W1995764068 @default.
• W2884943463 cites W1995963577 @default.
• W2884943463 cites W1996496566 @default.
• W2884943463 cites W1997358277 @default.
• W2884943463 cites W2000875498 @default.
• W2884943463 cites W2002586562 @default.
• W2884943463 cites W2004995700 @default.
• W2884943463 cites W2007171283 @default.
• W2884943463 cites W2007997420 @default.
• W2884943463 cites W2010062976 @default.
• W2884943463 cites W2012102114 @default.
• W2884943463 cites W2012965847 @default.
• W2884943463 cites W2016957425 @default.
• W2884943463 cites W2017347785 @default.
• W2884943463 cites W2018217184 @default.
• W2884943463 cites W2020739963 @default.
• W2884943463 cites W2020783997 @default.
• W2884943463 cites W2020947215 @default.
• W2884943463 cites W2021674095 @default.
• W2884943463 cites W2023387343 @default.
• W2884943463 cites W2028856723 @default.
• W2884943463 cites W2032628875 @default.
• W2884943463 cites W2033855909 @default.
• W2884943463 cites W2034146663 @default.
• W2884943463 cites W2034317184 @default.
• W2884943463 cites W203489449 @default.
• W2884943463 cites W2037204981 @default.
• W2884943463 cites W2037911245 @default.
• W2884943463 cites W2040118814 @default.
• W2884943463 cites W2041243503 @default.
• W2884943463 cites W2043779724 @default.
• W2884943463 cites W2045409504 @default.
• W2884943463 cites W2045758444 @default.
• W2884943463 cites W2045900081 @default.
• W2884943463 cites W2046357761 @default.
• W2884943463 cites W2050328125 @default.
• W2884943463 cites W2052738911 @default.
• W2884943463 cites W2053478411 @default.
• W2884943463 cites W2055053033 @default.
• W2884943463 cites W2056712045 @default.
• W2884943463 cites W2057299803 @default.
• W2884943463 cites W2058837644 @default.
• W2884943463 cites W2059115555 @default.
• W2884943463 cites W2059798983 @default.
• W2884943463 cites W2060057158 @default.
• W2884943463 cites W2061574765 @default.
• W2884943463 cites W2063420612 @default.
• W2884943463 cites W2063874785 @default.
• W2884943463 cites W2066336881 @default.
• W2884943463 cites W2067091330 @default.
• W2884943463 cites W2069514722 @default.
• W2884943463 cites W2069765215 @default.
• W2884943463 cites W2070018921 @default.
• W2884943463 cites W2071888455 @default.
• W2884943463 cites W2072967805 @default.
• W2884943463 cites W2073459918 @default.
• W2884943463 cites W2075824246 @default.
• W2884943463 cites W2075835114 @default.
• W2884943463 cites W2076704428 @default.
• W2884943463 cites W2077414996 @default.
• W2884943463 cites W2078439142 @default.
• W2884943463 cites W2078475387 @default.
• W2884943463 cites W2078479092 @default.
• W2884943463 cites W2079640584 @default.

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