Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884949921> ?p ?o ?g. }
- W2884949921 endingPage "521" @default.
- W2884949921 startingPage "512" @default.
- W2884949921 abstract "Significance The potential of protein therapeutics is limited because most proteins cannot reach the cytosol. Like many cell-penetrating peptides (CPPs), cell-permeant miniature proteins (CPMPs) that embody a penta-Arg motif are endocytosed; the difference is that CPMPs are released efficiently from endosomes while other CPPs are not. Here, we report that the trafficking of CPMPs into the cytosol requires the homotypic fusion and protein-sorting (HOPS) complex, a membrane-tethering complex that fuses Rab7 + endosomes. CPMPs neither inhibit nor activate HOPS function; instead, HOPS allows CPMPs to traffic into Lamp1 + endosomes as a prerequisite for endosomal escape. The identification of Lamp1 + late endosomes and lysosomes as portals for passing proteins into the cytosol will aid the development of next-generation biologics that overcome the limitations imposed by cellular membranes." @default.
- W2884949921 created "2018-08-03" @default.
- W2884949921 creator A5009101583 @default.
- W2884949921 creator A5021328301 @default.
- W2884949921 creator A5067830024 @default.
- W2884949921 creator A5069765122 @default.
- W2884949921 creator A5073929766 @default.
- W2884949921 creator A5076043843 @default.
- W2884949921 date "2019-01-04" @default.
- W2884949921 modified "2023-10-16" @default.
- W2884949921 title "HOPS-dependent endosomal fusion required for efficient cytosolic delivery of therapeutic peptides and small proteins" @default.
- W2884949921 cites W1193554 @default.
- W2884949921 cites W1493638 @default.
- W2884949921 cites W1519450813 @default.
- W2884949921 cites W1534198965 @default.
- W2884949921 cites W1534811759 @default.
- W2884949921 cites W1578330187 @default.
- W2884949921 cites W1583466614 @default.
- W2884949921 cites W1584683177 @default.
- W2884949921 cites W1670684017 @default.
- W2884949921 cites W1835592430 @default.
- W2884949921 cites W1844274376 @default.
- W2884949921 cites W1965411122 @default.
- W2884949921 cites W1979318608 @default.
- W2884949921 cites W1980149272 @default.
- W2884949921 cites W1986299453 @default.
- W2884949921 cites W2007647318 @default.
- W2884949921 cites W2008845432 @default.
- W2884949921 cites W2017642141 @default.
- W2884949921 cites W2019169633 @default.
- W2884949921 cites W2019407979 @default.
- W2884949921 cites W2023766870 @default.
- W2884949921 cites W2028858498 @default.
- W2884949921 cites W2029174147 @default.
- W2884949921 cites W2029682882 @default.
- W2884949921 cites W2032250529 @default.
- W2884949921 cites W2034812646 @default.
- W2884949921 cites W2035849683 @default.
- W2884949921 cites W2036797151 @default.
- W2884949921 cites W2040078811 @default.
- W2884949921 cites W2042143995 @default.
- W2884949921 cites W2045700382 @default.
- W2884949921 cites W2052080816 @default.
- W2884949921 cites W2052706007 @default.
- W2884949921 cites W2055791162 @default.
- W2884949921 cites W2064761355 @default.
- W2884949921 cites W2068130700 @default.
- W2884949921 cites W2069001964 @default.
- W2884949921 cites W2069981183 @default.
- W2884949921 cites W2076083257 @default.
- W2884949921 cites W2076859770 @default.
- W2884949921 cites W2077539982 @default.
- W2884949921 cites W2079335891 @default.
- W2884949921 cites W2088373848 @default.
- W2884949921 cites W2091644923 @default.
- W2884949921 cites W2094895270 @default.
- W2884949921 cites W2099540110 @default.
- W2884949921 cites W2101080130 @default.
- W2884949921 cites W2108585827 @default.
- W2884949921 cites W2110951885 @default.
- W2884949921 cites W2114072930 @default.
- W2884949921 cites W2115044534 @default.
- W2884949921 cites W2118278336 @default.
- W2884949921 cites W2123650819 @default.
- W2884949921 cites W2125924827 @default.
- W2884949921 cites W2133831816 @default.
- W2884949921 cites W2139946699 @default.
- W2884949921 cites W2140466892 @default.
- W2884949921 cites W2140915719 @default.
- W2884949921 cites W2141506589 @default.
- W2884949921 cites W2146980885 @default.
- W2884949921 cites W2148515049 @default.
- W2884949921 cites W2150091347 @default.
- W2884949921 cites W2150782426 @default.
- W2884949921 cites W2152024452 @default.
- W2884949921 cites W2152331121 @default.
- W2884949921 cites W2153026556 @default.
- W2884949921 cites W2158217645 @default.
- W2884949921 cites W2159852137 @default.
- W2884949921 cites W2166155213 @default.
- W2884949921 cites W2171033030 @default.
- W2884949921 cites W2219118753 @default.
- W2884949921 cites W2280662035 @default.
- W2884949921 cites W2312836697 @default.
- W2884949921 cites W2326124486 @default.
- W2884949921 cites W2328702355 @default.
- W2884949921 cites W2335878664 @default.
- W2884949921 cites W2346127285 @default.
- W2884949921 cites W2399628045 @default.
- W2884949921 cites W2412326609 @default.
- W2884949921 cites W2537623931 @default.
- W2884949921 cites W2555232419 @default.
- W2884949921 cites W2586724023 @default.
- W2884949921 cites W2588262749 @default.
- W2884949921 cites W2588609212 @default.
- W2884949921 cites W2588948193 @default.
- W2884949921 cites W2593116355 @default.
- W2884949921 cites W2604485757 @default.