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- W2884951805 abstract "Plenty of evidence showing that microRNAs (miRNAs) post-transcriptionally regulate gene expression and are involved in a wide range of biological processes. However, the roles of miRNAs in ovarian development process remain largely unknown in shrimp. In the present study, high-throughput sequencing of small RNAs was performed to find specific miRNAs that are involved in ovarian development process in Penaeus monodon. Two small RNA libraries were constructed from undeveloped (UNDEV group) and developed (DEV group) ovarian tissues in P. monodon. In total, 43 differentially expressed miRNAs were identified between the two groups (P ≤ 0.05, |log2 ratio| ≥1), and their expression profiles were validated by qRT-PCR. In order to further clarify the functional roles of these differentially expressed miRNAs during ovarian development process, target gene prediction was performed. In total, 4,102 target genes of 43 miRNAs were predicted, then clustered by the Kyoto Encyclopedia of Genes and Genomes (KEGG) database; only four specific pathways related to ovarian development were obtained (P < 0.05). Dual-luciferase reporter assays and integrated expression analysis were also conducted to further clarify the interaction between the miRNAs and their target mRNAs. This study provides important information about the function of miRNAs involved in ovarian developmental stages in P. monodon." @default.
- W2884951805 created "2018-08-03" @default.
- W2884951805 creator A5022217341 @default.
- W2884951805 creator A5023651982 @default.
- W2884951805 creator A5052744243 @default.
- W2884951805 date "2018-08-02" @default.
- W2884951805 modified "2023-10-14" @default.
- W2884951805 title "Identification of MicroRNAs and Their Target Genes Associated with Ovarian Development in Black Tiger Shrimp (Penaeus monodon) Using High-Throughput Sequencing" @default.
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- W2884951805 doi "https://doi.org/10.1038/s41598-018-29597-y" @default.
- W2884951805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6072753" @default.
- W2884951805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30072718" @default.
- W2884951805 hasPublicationYear "2018" @default.
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