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• W2884987673 startingPage "377" @default.
• W2884987673 abstract "The cricket, Gryllus bimaculatus, is a classic model of leg regeneration following amputation. We previously demonstrated that Gryllus decapentaplegic (Gb'dpp) is expressed during leg regeneration, although it remains unclear whether it is essential for this process. In this study, double-stranded RNA targeting the Smad mathers-against-dpp homolog, Gb'mad, was used to examine the role of bone morphogenetic protein (BMP) signaling in the leg regeneration process of Gryllus bimaculatus. RNA interference (RNAi)-mediated knockdown of Gb'mad led to a loss of tarsus regeneration at the most distal region of regenerating leg segments. Moreover, we confirmed that the phenotype obtained by knockdown of Dpp type I receptor, Thick veins (Gb'tkv), closely resembled that observed for Gb'mad RNAi crickets, thereby suggesting that the BMP signaling pathway is indispensable for the initial stages of tarsus formation. Interestingly, knockdown of Gb'mad and Gb'tkv resulted in significant elongation of regenerating tibia along the proximodistal axis compared with normal legs. Moreover, our findings indicate that during the regeneration of tibia, the BMP signaling pathway interacts with Dachsous/Fat (Gb'Ds/Gb'Ft) signaling and dachshund (Gb'dac) to re-establish positional information and regulate determination of leg size. Based on these observations, we discuss possible roles for Gb'mad in the distal patterning and intercalation processes during leg regeneration in Gryllus bimaculatus." @default.
• W2884987673 created "2018-08-03" @default.
• W2884987673 creator A5001842284 @default.
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• W2884987673 date "2018-07-24" @default.
• W2884987673 modified "2023-10-13" @default.
• W2884987673 title "Bone morphogenetic protein signaling in distal patterning and intercalation during leg regeneration of the cricket,<i>Gryllus bimaculatus</i>" @default.
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• W2884987673 doi "https://doi.org/10.1111/dgd.12560" @default.
• W2884987673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30043459" @default.
• W2884987673 hasPublicationYear "2018" @default.
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