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• W2884994513 abstract "Nonalcoholic steatohepatitis (NASH) is largely driven by the dysregulation of liver metabolism and inflammation. Bile acids and their receptor Farnesoid X receptor (FXR) play a critical role in the disease development. Here, we investigated whether INT-767, the newly-identified dual FXR/TGR5 agonist, can protect rat from liver injury during NASH.NASH model was established by feeding the male SD rats with high-fat diet for 16 weeks. INT-767 was given by gavage to NASH rats from week 13 to week 16. At the end of 16 weeks, liver and serum were harvested, and bile acids, glucose and lipid metabolism, liver injury and histological features were evaluated.INT-767 treatment significantly alleviates high-fat caused liver damage characterized with lipid accumulation and hepatic infiltration of immune cells. INT-767 robustly restores the lipid, glucose metabolism to normal level, attenuates insulin resistance through upregulating FXR level and reverting the dysregulation of its target genes in liver metabolism. Molecularly INT-767 also attenuates the pro-inflammatory response by suppression of TNF-α and NF-κB signaling pathway.INT-767 may be an attractive candidate for a potential novel strategy on the treatment of NASH." @default.
• W2884994513 created "2018-08-03" @default.
• W2884994513 creator A5034848501 @default.
• W2884994513 creator A5037879304 @default.
• W2884994513 creator A5078237117 @default.
• W2884994513 date "2018-07-01" @default.
• W2884994513 modified "2023-10-13" @default.
• W2884994513 title "Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis" @default.
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• W2884994513 doi "https://doi.org/10.2147/dddt.s170518" @default.
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• W2884994513 hasPublicationYear "2018" @default.
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