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• W2885015771 abstract "Growing evidence shows that improper intake of vitamin B6 increases cancer risk and several studies indicate that diabetic patients have a higher risk of developing tumors. We previously demonstrated that in Drosophila the deficiency of Pyridoxal 5' phosphate (PLP), the active form of vitamin B6, causes chromosome aberrations (CABs), one of cancer prerequisites, and increases hemolymph glucose content. Starting from these data we asked if it was possible to provide a link between the aforementioned studies. Thus, we tested the effect of low PLP levels on DNA integrity in diabetic cells. To this aim we generated two Drosophila models of type 2 diabetes, the first by impairing insulin signaling and the second by rearing flies in high sugar diet. We showed that glucose treatment induced CABs in diabetic individuals but not in controls. More interestingly, PLP deficiency caused high frequencies of CABs in both diabetic models demonstrating that hyperglycemia, combined to reduced PLP level, impairs DNA integrity. PLP-depleted diabetic cells accumulated Advanced Glycation End products (AGEs) that largely contribute to CABs as α-lipoic acid, an AGE inhibitor, rescued not only AGEs but also CABs. These data, extrapolated to humans, indicate that low PLP levels, impacting on DNA integrity, may be considered one of the possible links between diabetes and cancer." @default.
• W2885015771 created "2018-08-03" @default.
• W2885015771 creator A5007790566 @default.
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• W2885015771 creator A5082274972 @default.
• W2885015771 creator A5088657110 @default.
• W2885015771 date "2018-07-30" @default.
• W2885015771 modified "2023-09-30" @default.
• W2885015771 title "Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes" @default.
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• W2885015771 doi "https://doi.org/10.1038/s41598-018-29801-z" @default.
• W2885015771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6065437" @default.
• W2885015771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30061626" @default.
• W2885015771 hasPublicationYear "2018" @default.
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