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- W2885031718 abstract "Objective: Isosorbide mononitrate (ISMN), a well-known nitrate, have been widely used in the management of ischemic heart disease. Although it significantly alleviate angina pain, development of tolerance and its pro-oxidant properties have been provoking continuing debate. To this day, the effect of nitrate therapy on atherosclerotic formation remains unsolved. To elucidate this clinically-important problem, we examined the effect of ISMN treatment on the atherosclerotic formation using high-fat fed low density lipoprotein (LDL) receptor and heme oxygenase-2 double-deficient (LDL-R/HO-2 -/-) mice, in which only anti-oxidative and anti-inflammatory isoform of heme oxygenase-1 (HO-1) had been expressed in atherosclerotic arterial wall cells. We also examined the role of bilirubin, a product of HO-1 reaction, in these ISMN models. Methods: During 6 week high-fat diet, LDL-R/HO-2 -/- mice were treated with ISMN (2 mg/kg/day or 200 mg/kg/day). Control animals were treated with vehicle. After sacrifice, result..." @default.
- W2885031718 created "2018-08-22" @default.
- W2885031718 creator A5048325803 @default.
- W2885031718 date "2014-05-01" @default.
- W2885031718 modified "2023-09-23" @default.
- W2885031718 title "Abstract 261: Inhibitory Effect of Isosorbide Mononitrate on the Formation of Atherosclerosis in Low-Density Lipoprotein Receptor and Heme Oxygenase-2 Double Knockout Mice" @default.
- W2885031718 hasPublicationYear "2014" @default.
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