FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885037892> ?p ?o ?g. }

• W2885037892 endingPage "284" @default.
• W2885037892 startingPage "274" @default.
• W2885037892 abstract "Fluorogenic labeling is a potential technique in biology that allows for direct detection and tracking of cells undergoing various biological processes. Compared to traditional genetic modification approaches, labeling cells with nanoparticles has advantages, especially for the additional safety they provide by avoiding genomic integration. However, it remains a challenge to determine whether nanoparticles interfere with cell traits and provide long-lasting signals in living cells. We employed an amphiphilic fluorophore-derived nanoparticle (denoted by TPE-11) bearing a tetraphenylethene (TPE) moiety and two ionic heads; this nanoparticle has an aggregation-induced emission (AIE) effect and the ability to self-assemble. TPE-11 exhibited the property of higher or longer fluorescence intensities in cell imaging than the other two nanomaterials under the same conditions. We used this nanomaterial to label human embryonic stem (hES) cells and monitor their differentiation. Treatment with low concentrations of TPE-11 (8.0 μg/mL) resulted in high-intensity labeling of hES cells, and immunostaining analysis and teratoma formation assays showed that at this concentration, their pluripotency remained unaltered. TPE-11 nanoparticles allowed for long-term monitoring of hES cell differentiation into neuron-like cells; remarkably, strong nanoparticle signals were detected throughout the nearly 40-day differentiation process. Thus, these results demonstrate that the TPE-11 nanoparticle has excellent biocompatibility for hES cells and is a potential fluorogen for labeling and tracking the differentiation of human pluripotent stem cells. This study uses a nanoparticle-based approach to label human embryonic stem (hES) cells and monitor their differentiation. hES cells are distinguished by two distinctive properties: the state of their pluripotency and the potential to differentiate into various cell types. Thus, these cells will be useful as a source of cells for transplantation or tissue engineering applications. We noticed the effect of aggregation-induced emission, and the ability to self-assemble could enhance the persistence of signals. Treatment with low concentrations of TPE-11 nanoparticles showed high-intensity labeling of hES cells, and immunostaining analysis and teratoma formation assays showed that at this concentration, their pluripotency remained unaltered. Additionally, these nanoparticles allowed for long-term monitoring of hES cell differentiation into neuron-like cells lasting for 40 days." @default.
• W2885037892 created "2018-08-22" @default.
• W2885037892 creator A5001605572 @default.
• W2885037892 creator A5038791444 @default.
• W2885037892 creator A5039052622 @default.
• W2885037892 creator A5040425022 @default.
• W2885037892 creator A5041294713 @default.
• W2885037892 creator A5074461919 @default.
• W2885037892 creator A5074490226 @default.
• W2885037892 creator A5076523051 @default.
• W2885037892 creator A5078649390 @default.
• W2885037892 creator A5079680509 @default.
• W2885037892 date "2018-09-01" @default.
• W2885037892 modified "2023-10-16" @default.
• W2885037892 title "Application of amphiphilic fluorophore-derived nanoparticles to provide contrast to human embryonic stem cells without affecting their pluripotency and to monitor their differentiation into neuron-like cells" @default.
• W2885037892 cites W1473386422 @default.
• W2885037892 cites W1526595001 @default.
• W2885037892 cites W1771588344 @default.
• W2885037892 cites W1965161030 @default.
• W2885037892 cites W1979697767 @default.
• W2885037892 cites W1990555407 @default.
• W2885037892 cites W1990813571 @default.
• W2885037892 cites W1998047469 @default.
• W2885037892 cites W2000703762 @default.
• W2885037892 cites W2001029428 @default.
• W2885037892 cites W2020189938 @default.
• W2885037892 cites W2023198955 @default.
• W2885037892 cites W2031378691 @default.
• W2885037892 cites W2032338594 @default.
• W2885037892 cites W2033197664 @default.
• W2885037892 cites W2033284482 @default.
• W2885037892 cites W2038455758 @default.
• W2885037892 cites W2041972032 @default.
• W2885037892 cites W2044008891 @default.
• W2885037892 cites W2044521110 @default.
• W2885037892 cites W2066301717 @default.
• W2885037892 cites W2066717075 @default.
• W2885037892 cites W2067311708 @default.
• W2885037892 cites W2067683181 @default.
• W2885037892 cites W2079478685 @default.
• W2885037892 cites W2080795320 @default.
• W2885037892 cites W2086943348 @default.
• W2885037892 cites W2090810663 @default.
• W2885037892 cites W2111586718 @default.
• W2885037892 cites W2130128490 @default.
• W2885037892 cites W2148890861 @default.
• W2885037892 cites W2152069828 @default.
• W2885037892 cites W2159182565 @default.
• W2885037892 cites W2171656799 @default.
• W2885037892 cites W2230903848 @default.
• W2885037892 cites W2315300672 @default.
• W2885037892 cites W2315752176 @default.
• W2885037892 cites W2615383334 @default.
• W2885037892 cites W2734716724 @default.
• W2885037892 cites W2741192958 @default.
• W2885037892 cites W2769216568 @default.
• W2885037892 doi "https://doi.org/10.1016/j.actbio.2018.07.051" @default.
• W2885037892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30071352" @default.
• W2885037892 hasPublicationYear "2018" @default.
• W2885037892 type Work @default.
• W2885037892 sameAs 2885037892 @default.
• W2885037892 citedByCount "9" @default.
• W2885037892 countsByYear W28850378922019 @default.
• W2885037892 countsByYear W28850378922020 @default.
• W2885037892 countsByYear W28850378922021 @default.
• W2885037892 countsByYear W28850378922022 @default.
• W2885037892 crossrefType "journal-article" @default.
• W2885037892 hasAuthorship W2885037892A5001605572 @default.
• W2885037892 hasAuthorship W2885037892A5038791444 @default.
• W2885037892 hasAuthorship W2885037892A5039052622 @default.
• W2885037892 hasAuthorship W2885037892A5040425022 @default.
• W2885037892 hasAuthorship W2885037892A5041294713 @default.
• W2885037892 hasAuthorship W2885037892A5074461919 @default.
• W2885037892 hasAuthorship W2885037892A5074490226 @default.
• W2885037892 hasAuthorship W2885037892A5076523051 @default.
• W2885037892 hasAuthorship W2885037892A5078649390 @default.
• W2885037892 hasAuthorship W2885037892A5079680509 @default.
• W2885037892 hasConcept C104317684 @default.
• W2885037892 hasConcept C107459253 @default.
• W2885037892 hasConcept C121332964 @default.
• W2885037892 hasConcept C12554922 @default.
• W2885037892 hasConcept C145103041 @default.
• W2885037892 hasConcept C148738053 @default.
• W2885037892 hasConcept C155672457 @default.
• W2885037892 hasConcept C171250308 @default.
• W2885037892 hasConcept C185592680 @default.
• W2885037892 hasConcept C191897082 @default.
• W2885037892 hasConcept C192562407 @default.
• W2885037892 hasConcept C203014093 @default.
• W2885037892 hasConcept C204232928 @default.
• W2885037892 hasConcept C2777230088 @default.
• W2885037892 hasConcept C2778617687 @default.
• W2885037892 hasConcept C28328180 @default.
• W2885037892 hasConcept C4224716 @default.
• W2885037892 hasConcept C55493867 @default.
• W2885037892 hasConcept C62520636 @default.
• W2885037892 hasConcept C86803240 @default.
• W2885037892 hasConcept C91881484 @default.

• next