FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885038553> ?p ?o ?g. }

• W2885038553 abstract "Cervical cancer is the second most prevalent cancer among women of child-bearing age in Ethiopia. The aim of this study was to determine human papilloma virus (HPV) genotype distribution among HIV-negative women with normal and abnormal cervical cytology results.We investigated a consecutive of 233 HIV-negative women between December 2008 and March 2009 presenting in a Tertiary Gynecology Referral Clinic in Ethiopia. Screening was done by Pap cytology and HPV detection and genotyping method was nested PCR (direct amplification with MY09/MY11 primers, followed by nested amplification with GP5/GP6 primers) and sequencing of the nested products. Sequencing of the non-purified nested PCR products was performed following re-amplification with Big dye terminator, using the GP6 primer.Of the 233 study participants, 92 (39.5%) had abnormal cytology. All women with abnormal cervical cytology had positive HPV DNA compared to only 48.9% of those presenting with normal cytology. Of these women, the frequency of high-risk (HR)-HPV was 83.2% and its prevalence in women with abnormal cervical cytology was significantly higher than those with normal cytology (92.4% vs. 71%, p < 0.0001). The most frequent genotypes identified were HPV16 (44.1%), followed by HPV35 and HPV45 (each 6.2%), HPV31 (4.4%), HPV56 (3.7%), HPV18 and HPV59 (each 3.1%), HPV58 (2.5%) and HPV39 (1.9%). While the most common HR-HPV infections among women with normal cytology were HPV16 (20.3%), followed by HPV35 (8.7%), HPV56 and HPV58 (each 5.8%), HPV18, HPV31 and HPV39 (each 4.4%), HPV45 (2.9%) and HPV59 and HPV68 (each 1.5%), the most common HR-HPV infections in women with abnormal cytology included HPV16 (62%), followed by HPV45 (8.7%), HPV 31, HPV35 and HPV59 (each 4.4%), and HPV18, HPV52 and HPV56 (each 2.2%). We also noted low prevalence of multiple HPV infections in women with normal or abnormal cytology. Multivariable logistic analysis showed that residing in rural area (OR 3.24, 95% CI: 1.13-9.30), being multipara (OR 7.35, 95% CI: 1.78-30.38) and having abnormal cervical cytology results (OR 6.75, 95% CI: 1.78-25.57) were all independently associated with HPV16 genotype.Our study revealed a significant risk of infection with HR-HPV, in particular with HPV16 genotype, in women attending a referral center in Ethiopian women presenting with or without abnormal cervical cytology. Moreover, Pap smear cytology missed a significant proportion of women compared to those who were identified by PCR for HR-HPV infections. In addition, the PCR method we used was not suitable for sensitive detection of co-existent multiple infections. Data from the present study indicate that currently available HPV vaccines could prevent nearly 67% of all cervical cancer cases in women in Ethiopia." @default.
• W2885038553 created "2018-08-22" @default.
• W2885038553 creator A5004061432 @default.
• W2885038553 creator A5009246498 @default.
• W2885038553 creator A5035361569 @default.
• W2885038553 creator A5048485020 @default.
• W2885038553 creator A5057212485 @default.
• W2885038553 creator A5063034794 @default.
• W2885038553 creator A5063467555 @default.
• W2885038553 creator A5076717551 @default.
• W2885038553 creator A5081336232 @default.
• W2885038553 date "2018-08-14" @default.
• W2885038553 modified "2023-10-16" @default.
• W2885038553 title "HPV genotype distribution among women with normal and abnormal cervical cytology presenting in a tertiary gynecology referral Clinic in Ethiopia" @default.
• W2885038553 cites W1601036107 @default.
• W2885038553 cites W1965926544 @default.
• W2885038553 cites W1980563950 @default.
• W2885038553 cites W1990398387 @default.
• W2885038553 cites W2039745983 @default.
• W2885038553 cites W2052987283 @default.
• W2885038553 cites W2053131735 @default.
• W2885038553 cites W2055688085 @default.
• W2885038553 cites W2084836260 @default.
• W2885038553 cites W2095250514 @default.
• W2885038553 cites W2100367404 @default.
• W2885038553 cites W2114212562 @default.
• W2885038553 cites W2160382477 @default.
• W2885038553 cites W2168981334 @default.
• W2885038553 cites W2306530628 @default.
• W2885038553 cites W2333429195 @default.
• W2885038553 cites W2411515213 @default.
• W2885038553 cites W2466140194 @default.
• W2885038553 cites W46765896 @default.
• W2885038553 doi "https://doi.org/10.1186/s13027-018-0201-x" @default.
• W2885038553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6092870" @default.
• W2885038553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30127841" @default.
• W2885038553 hasPublicationYear "2018" @default.
• W2885038553 type Work @default.
• W2885038553 sameAs 2885038553 @default.
• W2885038553 citedByCount "24" @default.
• W2885038553 countsByYear W28850385532019 @default.
• W2885038553 countsByYear W28850385532020 @default.
• W2885038553 countsByYear W28850385532021 @default.
• W2885038553 countsByYear W28850385532022 @default.
• W2885038553 countsByYear W28850385532023 @default.
• W2885038553 crossrefType "journal-article" @default.
• W2885038553 hasAuthorship W2885038553A5004061432 @default.
• W2885038553 hasAuthorship W2885038553A5009246498 @default.
• W2885038553 hasAuthorship W2885038553A5035361569 @default.
• W2885038553 hasAuthorship W2885038553A5048485020 @default.
• W2885038553 hasAuthorship W2885038553A5057212485 @default.
• W2885038553 hasAuthorship W2885038553A5063034794 @default.
• W2885038553 hasAuthorship W2885038553A5063467555 @default.
• W2885038553 hasAuthorship W2885038553A5076717551 @default.
• W2885038553 hasAuthorship W2885038553A5081336232 @default.
• W2885038553 hasBestOaLocation W28850385531 @default.
• W2885038553 hasConcept C104317684 @default.
• W2885038553 hasConcept C121608353 @default.
• W2885038553 hasConcept C126322002 @default.
• W2885038553 hasConcept C131872663 @default.
• W2885038553 hasConcept C135763542 @default.
• W2885038553 hasConcept C142724271 @default.
• W2885038553 hasConcept C157431215 @default.
• W2885038553 hasConcept C167135981 @default.
• W2885038553 hasConcept C18823058 @default.
• W2885038553 hasConcept C2776135927 @default.
• W2885038553 hasConcept C2778220009 @default.
• W2885038553 hasConcept C2780283434 @default.
• W2885038553 hasConcept C29456083 @default.
• W2885038553 hasConcept C31467283 @default.
• W2885038553 hasConcept C49105822 @default.
• W2885038553 hasConcept C512399662 @default.
• W2885038553 hasConcept C55493867 @default.
• W2885038553 hasConcept C71924100 @default.
• W2885038553 hasConcept C86803240 @default.
• W2885038553 hasConceptScore W2885038553C104317684 @default.
• W2885038553 hasConceptScore W2885038553C121608353 @default.
• W2885038553 hasConceptScore W2885038553C126322002 @default.
• W2885038553 hasConceptScore W2885038553C131872663 @default.
• W2885038553 hasConceptScore W2885038553C135763542 @default.
• W2885038553 hasConceptScore W2885038553C142724271 @default.
• W2885038553 hasConceptScore W2885038553C157431215 @default.
• W2885038553 hasConceptScore W2885038553C167135981 @default.
• W2885038553 hasConceptScore W2885038553C18823058 @default.
• W2885038553 hasConceptScore W2885038553C2776135927 @default.
• W2885038553 hasConceptScore W2885038553C2778220009 @default.
• W2885038553 hasConceptScore W2885038553C2780283434 @default.
• W2885038553 hasConceptScore W2885038553C29456083 @default.
• W2885038553 hasConceptScore W2885038553C31467283 @default.
• W2885038553 hasConceptScore W2885038553C49105822 @default.
• W2885038553 hasConceptScore W2885038553C512399662 @default.
• W2885038553 hasConceptScore W2885038553C55493867 @default.
• W2885038553 hasConceptScore W2885038553C71924100 @default.
• W2885038553 hasConceptScore W2885038553C86803240 @default.
• W2885038553 hasIssue "1" @default.
• W2885038553 hasLocation W28850385531 @default.
• W2885038553 hasLocation W28850385532 @default.
• W2885038553 hasLocation W28850385533 @default.
• W2885038553 hasLocation W28850385534 @default.
• W2885038553 hasLocation W28850385535 @default.

• next