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- W2885048311 abstract "We report a case of prostatic carcinosarcoma, a rare variant of prostatic cancer, which is composed of a mixture of epithelial and mesenchymal components with a generally poor outcome.We aim to identify molecular alterations, in particular copy number variations of AR and c -MYC genes, methylation and expression of glutathione S-transferase P1 (GSTP1), programmed death-ligand 1 (PD-L1), AR, and phosphorylated AR expression.We found a distinct molecular pattern between adenocarcinoma and carcinosarcoma, which was characterized by high AR copy number variation gain; positive expression of PD-L1, AR, and phosphorylated AR; low espression of GSTP1 in epithelial component. The sarcomatoid component had a lower gain of the AR gene, and no expression of PD-L1, AR, phosphorylated AR, or GSTP1. Both components had a gain of c-MYC copy number variation.Our findings suggest that carcinosarcoma has specific molecular characteristics that could be indicative for early diagnosis and treatment selection." @default.
- W2885048311 created "2018-08-22" @default.
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- W2885048311 date "2018-08-12" @default.
- W2885048311 modified "2023-09-26" @default.
- W2885048311 title "Carcinosarcoma of the prostate: case report with molecular and histological characterization" @default.
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- W2885048311 doi "https://doi.org/10.1177/1724600818791463" @default.
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