FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885048965> ?p ?o ?g. }

• W2885048965 endingPage "1952" @default.
• W2885048965 startingPage "1937" @default.
• W2885048965 abstract "Decompensated cirrhosis is characterized by exuberant systemic inflammation. Although the inducers of this feature remain unknown, the presence of circulating forms of oxidized albumin, namely human nonmercaptalbumin 1 (HNA1) and HNA2, is a common finding in cirrhosis. The aim of this study was to explore the ability of these oxidized albumin forms to induce systemic inflammation by triggering the activation of peripheral leukocytes. We observed significantly higher plasma levels of HNA1 and HNA2 in patients with cirrhosis (n = 256) compared to healthy volunteers (n = 48), which gradually increased during the course from compensated to decompensated to acute-on-chronic liver failure. Plasma HNA1 and HNA2 levels significantly correlated with inflammatory markers (i.e., interleukin-6 [IL-6], IL-1β, tumor necrosis factor-alpha [TNF-α] and IL-8) in patients with cirrhosis. To directly test the inflammatory effects of HNA1 and HNA2 on leukocytes, these oxidized albumin forms were prepared ex vivo and their posttranslational modifications monitored by liquid chromatography (LC)-quadrupole time-of-flight/mass spectrometry (MS). HNA1, but not HNA2, increased IL-1β, IL-6, and TNF-α mRNA and protein expression in leukocytes from both healthy volunteers and patients with cirrhosis. Moreover, HNA1 up-regulated the expression of eicosanoid-generating enzymes (i.e., cyclooxygenase-2 [COX-2] and microsomal prostaglandin E [PGE] synthase 1) and the production of inflammatory eicosanoids (PGE2 , PGF2α , thromboxane B2 , and leukotriene B4 ), as determined by LC-electrospray ionization-MS/MS. The inflammatory response to HNA1 was more pronounced in peripheral blood mononuclear cells (PBMCs) and marginal in polymorphonuclear neutrophils. Kinome analysis of PBMCs revealed that HNA1 induced the phosphorylation of p38 mitogen-activated protein kinase, the inhibition of which blocked HNA1-induced cytokine and COX-2 induction. Conclusion: HNA1 triggers an inflammatory response in PBMCs, providing a rationale for its removal and replacement by reduced albumin in the prevention of systemic inflammation in patients with advanced liver disease." @default.
• W2885048965 created "2018-08-22" @default.
• W2885048965 creator A5013316271 @default.
• W2885048965 creator A5026730867 @default.
• W2885048965 creator A5028869995 @default.
• W2885048965 creator A5029609610 @default.
• W2885048965 creator A5033355668 @default.
• W2885048965 creator A5036022888 @default.
• W2885048965 creator A5049933888 @default.
• W2885048965 creator A5058760209 @default.
• W2885048965 creator A5066290707 @default.
• W2885048965 creator A5082616191 @default.
• W2885048965 creator A5086126811 @default.
• W2885048965 date "2018-10-13" @default.
• W2885048965 modified "2023-10-18" @default.
• W2885048965 title "Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen‐Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis" @default.
• W2885048965 cites W1575436886 @default.
• W2885048965 cites W1766122222 @default.
• W2885048965 cites W1901598726 @default.
• W2885048965 cites W1994460343 @default.
• W2885048965 cites W1998643708 @default.
• W2885048965 cites W2006957711 @default.
• W2885048965 cites W2007670274 @default.
• W2885048965 cites W2023455126 @default.
• W2885048965 cites W2046702516 @default.
• W2885048965 cites W2062502161 @default.
• W2885048965 cites W2068319865 @default.
• W2885048965 cites W2083082460 @default.
• W2885048965 cites W2103951348 @default.
• W2885048965 cites W2118765712 @default.
• W2885048965 cites W2120631754 @default.
• W2885048965 cites W2125326232 @default.
• W2885048965 cites W2140044845 @default.
• W2885048965 cites W2144416322 @default.
• W2885048965 cites W2155712158 @default.
• W2885048965 cites W2168090948 @default.
• W2885048965 cites W2217807288 @default.
• W2885048965 cites W2322673970 @default.
• W2885048965 cites W2418438757 @default.
• W2885048965 cites W2514899465 @default.
• W2885048965 cites W2533320009 @default.
• W2885048965 cites W2535574647 @default.
• W2885048965 cites W2616932765 @default.
• W2885048965 doi "https://doi.org/10.1002/hep.30135" @default.
• W2885048965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30070728" @default.
• W2885048965 hasPublicationYear "2018" @default.
• W2885048965 type Work @default.
• W2885048965 sameAs 2885048965 @default.
• W2885048965 citedByCount "60" @default.
• W2885048965 countsByYear W28850489652018 @default.
• W2885048965 countsByYear W28850489652019 @default.
• W2885048965 countsByYear W28850489652020 @default.
• W2885048965 countsByYear W28850489652021 @default.
• W2885048965 countsByYear W28850489652022 @default.
• W2885048965 countsByYear W28850489652023 @default.
• W2885048965 crossrefType "journal-article" @default.
• W2885048965 hasAuthorship W2885048965A5013316271 @default.
• W2885048965 hasAuthorship W2885048965A5026730867 @default.
• W2885048965 hasAuthorship W2885048965A5028869995 @default.
• W2885048965 hasAuthorship W2885048965A5029609610 @default.
• W2885048965 hasAuthorship W2885048965A5033355668 @default.
• W2885048965 hasAuthorship W2885048965A5036022888 @default.
• W2885048965 hasAuthorship W2885048965A5049933888 @default.
• W2885048965 hasAuthorship W2885048965A5058760209 @default.
• W2885048965 hasAuthorship W2885048965A5066290707 @default.
• W2885048965 hasAuthorship W2885048965A5082616191 @default.
• W2885048965 hasAuthorship W2885048965A5086126811 @default.
• W2885048965 hasBestOaLocation W28850489651 @default.
• W2885048965 hasConcept C126322002 @default.
• W2885048965 hasConcept C134018914 @default.
• W2885048965 hasConcept C137061746 @default.
• W2885048965 hasConcept C17991360 @default.
• W2885048965 hasConcept C185592680 @default.
• W2885048965 hasConcept C202751555 @default.
• W2885048965 hasConcept C203014093 @default.
• W2885048965 hasConcept C2776125364 @default.
• W2885048965 hasConcept C2776252253 @default.
• W2885048965 hasConcept C2776685179 @default.
• W2885048965 hasConcept C2776914184 @default.
• W2885048965 hasConcept C2777214474 @default.
• W2885048965 hasConcept C2778690821 @default.
• W2885048965 hasConcept C55493867 @default.
• W2885048965 hasConcept C71924100 @default.
• W2885048965 hasConceptScore W2885048965C126322002 @default.
• W2885048965 hasConceptScore W2885048965C134018914 @default.
• W2885048965 hasConceptScore W2885048965C137061746 @default.
• W2885048965 hasConceptScore W2885048965C17991360 @default.
• W2885048965 hasConceptScore W2885048965C185592680 @default.
• W2885048965 hasConceptScore W2885048965C202751555 @default.
• W2885048965 hasConceptScore W2885048965C203014093 @default.
• W2885048965 hasConceptScore W2885048965C2776125364 @default.
• W2885048965 hasConceptScore W2885048965C2776252253 @default.
• W2885048965 hasConceptScore W2885048965C2776685179 @default.
• W2885048965 hasConceptScore W2885048965C2776914184 @default.
• W2885048965 hasConceptScore W2885048965C2777214474 @default.
• W2885048965 hasConceptScore W2885048965C2778690821 @default.
• W2885048965 hasConceptScore W2885048965C55493867 @default.
• W2885048965 hasConceptScore W2885048965C71924100 @default.

• next