FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885056455> ?p ?o ?g. }

• W2885056455 abstract "Arterial hyperoxia may induce vasoconstriction and reduce cardiac output, which is particularly undesirable in patients who already have compromised perfusion of vital organs. Due to the inaccessibility of vital organs in humans, vasoconstrictive effects of hyperoxia have primarily been studied in animal models. However, the results of these studies vary substantially. Here, we investigate the variation in magnitude of the hyperoxia effect among studies and explore possible sources of heterogeneity, such as vascular region and animal species.Pubmed and Embase were searched for eligible studies up to November 2017. In vivo and ex vivo animal studies reporting on vascular tone changes induced by local or systemic normobaric hyperoxia were included. Experiments with co-interventions (e.g. disease or endothelium removal) or studies focusing on lung, brain or fetal vasculature or the ductus arteriosus were not included. We extracted data pertaining to species, vascular region, blood vessel characteristics and method of hyperoxia induction. Overall effect sizes were estimated with a standardized mean difference (SMD) random effects model.We identified a total of 60 studies, which reported data on 67 in vivo and 18 ex vivo experiments. In the in vivo studies, hyperoxia caused vasoconstriction with an SMD of - 1.42 (95% CI - 1.65 to - 1.19). Ex vivo, the overall effect size was SMD - 0.56 (95% CI - 1.09 to - 0.03). Between-study heterogeneity (I2) was high for in vivo (72%, 95% CI 62 to 85%) and ex vivo studies (86%, 95% CI 78 to 98%). In vivo, in comparison to the overall effect size, hyperoxic vasoconstriction was less pronounced in the intestines and skin (P = 0.03) but enhanced in the cremaster muscle region (P < 0.001). Increased constriction was seen in vessels 15-25 μm in diameter. Hyperoxic constriction appeared to be directly proportional to oxygen concentration. For ex vivo studies, heterogeneity could not be explained with subgroup analysis.The effect of hyperoxia on vascular tone is substantially higher in vivo than ex vivo. The magnitude of the constriction is most pronounced in vessels ~ 15-25 μm in diameter and is proportional to the level of hyperoxia. Relatively increased constriction was seen in muscle vasculature, while reduced constriction was seen in the skin and intestines." @default.
• W2885056455 created "2018-08-22" @default.
• W2885056455 creator A5000013385 @default.
• W2885056455 creator A5006309963 @default.
• W2885056455 creator A5017531203 @default.
• W2885056455 creator A5043315520 @default.
• W2885056455 creator A5057808566 @default.
• W2885056455 creator A5057836299 @default.
• W2885056455 creator A5064022439 @default.
• W2885056455 creator A5083887066 @default.
• W2885056455 date "2018-08-04" @default.
• W2885056455 modified "2023-10-13" @default.
• W2885056455 title "Effects of hyperoxia on vascular tone in animal models: systematic review and meta-analysis" @default.
• W2885056455 cites W1438680585 @default.
• W2885056455 cites W1507205421 @default.
• W2885056455 cites W1786829471 @default.
• W2885056455 cites W183148266 @default.
• W2885056455 cites W1870364570 @default.
• W2885056455 cites W1879916716 @default.
• W2885056455 cites W1918204060 @default.
• W2885056455 cites W1936677313 @default.
• W2885056455 cites W1963656657 @default.
• W2885056455 cites W1968321219 @default.
• W2885056455 cites W1975890282 @default.
• W2885056455 cites W1979774496 @default.
• W2885056455 cites W1982662524 @default.
• W2885056455 cites W1982896936 @default.
• W2885056455 cites W1984390712 @default.
• W2885056455 cites W1992313394 @default.
• W2885056455 cites W1993056616 @default.
• W2885056455 cites W1993405930 @default.
• W2885056455 cites W1999090874 @default.
• W2885056455 cites W2005527315 @default.
• W2885056455 cites W2005711140 @default.
• W2885056455 cites W2008602734 @default.
• W2885056455 cites W2011411086 @default.
• W2885056455 cites W2012491995 @default.
• W2885056455 cites W2014206832 @default.
• W2885056455 cites W2015634907 @default.
• W2885056455 cites W2015752045 @default.
• W2885056455 cites W2031738511 @default.
• W2885056455 cites W2033585778 @default.
• W2885056455 cites W2035556792 @default.
• W2885056455 cites W2043385084 @default.
• W2885056455 cites W2048675209 @default.
• W2885056455 cites W2048698670 @default.
• W2885056455 cites W2049579935 @default.
• W2885056455 cites W2058998046 @default.
• W2885056455 cites W2062503388 @default.
• W2885056455 cites W2070211004 @default.
• W2885056455 cites W2070527076 @default.
• W2885056455 cites W2080343296 @default.
• W2885056455 cites W2088928458 @default.
• W2885056455 cites W2093884000 @default.
• W2885056455 cites W2101891501 @default.
• W2885056455 cites W2105871663 @default.
• W2885056455 cites W2110239296 @default.
• W2885056455 cites W2110625603 @default.
• W2885056455 cites W2114297749 @default.
• W2885056455 cites W2115043583 @default.
• W2885056455 cites W2117200377 @default.
• W2885056455 cites W2119228425 @default.
• W2885056455 cites W2131464004 @default.
• W2885056455 cites W2142635246 @default.
• W2885056455 cites W2145214437 @default.
• W2885056455 cites W2147945311 @default.
• W2885056455 cites W2149230682 @default.
• W2885056455 cites W2149423296 @default.
• W2885056455 cites W2156098321 @default.
• W2885056455 cites W2156809602 @default.
• W2885056455 cites W2162658182 @default.
• W2885056455 cites W2164074199 @default.
• W2885056455 cites W2166204906 @default.
• W2885056455 cites W2171112058 @default.
• W2885056455 cites W2171611414 @default.
• W2885056455 cites W2178669657 @default.
• W2885056455 cites W2179315784 @default.
• W2885056455 cites W2182005969 @default.
• W2885056455 cites W2182323656 @default.
• W2885056455 cites W2187351197 @default.
• W2885056455 cites W2195106579 @default.
• W2885056455 cites W2213111413 @default.
• W2885056455 cites W2215433200 @default.
• W2885056455 cites W2228034435 @default.
• W2885056455 cites W2233270811 @default.
• W2885056455 cites W2256365768 @default.
• W2885056455 cites W2258863907 @default.
• W2885056455 cites W2274583998 @default.
• W2885056455 cites W2300893170 @default.
• W2885056455 cites W2316197291 @default.
• W2885056455 cites W231911488 @default.
• W2885056455 cites W2394606473 @default.
• W2885056455 cites W2395507550 @default.
• W2885056455 cites W2398779272 @default.
• W2885056455 cites W2399833787 @default.
• W2885056455 cites W2407978659 @default.
• W2885056455 cites W2409146641 @default.
• W2885056455 cites W2409170312 @default.
• W2885056455 cites W2411180473 @default.
• W2885056455 cites W2415858107 @default.

• next