FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885069373> ?p ?o ?g. }

• W2885069373 abstract "Isolation stress is a major risk factor for neuropsychiatric disorders such as depressive and anxiety disorders. However, the molecular mechanisms underlying isolation-induced neuropsychiatric disorders remain elusive. In the present study, we investigated the subcellular mechanisms by which long-term isolation elicits depression and anxiety-related behaviors in mice. First, we found that long-term isolation induced depression-related behaviors in the forced swimming test (FST) and the sucrose preference test, as well as anxiety-related behaviors in the elevated zero maze test (EZMT) and the open field test. Next, we showed that intracentral amygdala (CeA) injection of oxytocin (OXT), but not intracerebroventricular injection, attenuated isolation-induced depression and anxiety-related behaviors via oxytocin receptor (OXTR), not vasopressin-1a receptor (V1aR), in the FST and EZMT, respectively. Quantitative real-time polymerase chain reaction analysis revealed that after 5 weeks of isolation, mRNA transcription of OXTR in the CeA, but not that of V1aR, significantly decreased, whereas OXT and vasopressin mRNA transcription in the paraventricular nucleus of hypothalamus did not change significantly. Whole-cell patch clamping of acute brain slices demonstrated that the frequency of miniature inhibitory postsynaptic currents (mIPSCs) in CeA neurons, but not their amplitude, was lower in isolated mice than in group-housed mice. Notably, OXT treatment increased the mIPSC frequency in the CeA neurons, but to a lesser extent in the case of isolated mice than in that of group-housed mice via OXTR. Taken together, our findings suggest that long-term isolation down-regulates OXTR mRNA transcription and diminishes OXT-induced inhibitory synaptic transmission in the CeA and may contribute to the development of depression and anxiety-related behaviors in isolated mice through the enhancement of CeA activity." @default.
• W2885069373 created "2018-08-22" @default.
• W2885069373 creator A5020423857 @default.
• W2885069373 creator A5025016732 @default.
• W2885069373 creator A5030657851 @default.
• W2885069373 creator A5032966324 @default.
• W2885069373 creator A5033091196 @default.
• W2885069373 creator A5047844519 @default.
• W2885069373 creator A5053059331 @default.
• W2885069373 creator A5059648067 @default.
• W2885069373 creator A5065258137 @default.
• W2885069373 creator A5070467399 @default.
• W2885069373 creator A5080306320 @default.
• W2885069373 creator A5084010479 @default.
• W2885069373 creator A5084583476 @default.
• W2885069373 creator A5088794645 @default.
• W2885069373 date "2018-08-14" @default.
• W2885069373 modified "2023-10-12" @default.
• W2885069373 title "Long-Term Isolation Elicits Depression and Anxiety-Related Behaviors by Reducing Oxytocin-Induced GABAergic Transmission in Central Amygdala" @default.
• W2885069373 cites W1803779312 @default.
• W2885069373 cites W1823169087 @default.
• W2885069373 cites W1890045606 @default.
• W2885069373 cites W1895314533 @default.
• W2885069373 cites W1906877753 @default.
• W2885069373 cites W1969375325 @default.
• W2885069373 cites W1972695948 @default.
• W2885069373 cites W1990916945 @default.
• W2885069373 cites W1994025579 @default.
• W2885069373 cites W1998872047 @default.
• W2885069373 cites W1998893802 @default.
• W2885069373 cites W1999269819 @default.
• W2885069373 cites W2001142434 @default.
• W2885069373 cites W2016117011 @default.
• W2885069373 cites W2018899064 @default.
• W2885069373 cites W2023636464 @default.
• W2885069373 cites W2033720614 @default.
• W2885069373 cites W2036707712 @default.
• W2885069373 cites W2037457456 @default.
• W2885069373 cites W2045102260 @default.
• W2885069373 cites W2051405502 @default.
• W2885069373 cites W2057498829 @default.
• W2885069373 cites W2057704927 @default.
• W2885069373 cites W2061455531 @default.
• W2885069373 cites W2064896421 @default.
• W2885069373 cites W2068471892 @default.
• W2885069373 cites W2091857612 @default.
• W2885069373 cites W2092986516 @default.
• W2885069373 cites W2095308161 @default.
• W2885069373 cites W2095898364 @default.
• W2885069373 cites W2098216509 @default.
• W2885069373 cites W2103274674 @default.
• W2885069373 cites W2139092358 @default.
• W2885069373 cites W2153566421 @default.
• W2885069373 cites W2159428856 @default.
• W2885069373 cites W2162954233 @default.
• W2885069373 cites W2163349072 @default.
• W2885069373 cites W2165172518 @default.
• W2885069373 cites W2167900457 @default.
• W2885069373 cites W2168161193 @default.
• W2885069373 cites W2223105696 @default.
• W2885069373 cites W2337855504 @default.
• W2885069373 cites W2569535213 @default.
• W2885069373 cites W2571229247 @default.
• W2885069373 cites W2590592231 @default.
• W2885069373 cites W2744823132 @default.
• W2885069373 cites W2790586369 @default.
• W2885069373 cites W2794146692 @default.
• W2885069373 cites W33568228 @default.
• W2885069373 cites W4234682840 @default.
• W2885069373 cites W4256434846 @default.
• W2885069373 cites W581256308 @default.
• W2885069373 cites W2148169226 @default.
• W2885069373 doi "https://doi.org/10.3389/fnmol.2018.00246" @default.
• W2885069373 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6104450" @default.
• W2885069373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30158853" @default.
• W2885069373 hasPublicationYear "2018" @default.
• W2885069373 type Work @default.
• W2885069373 sameAs 2885069373 @default.
• W2885069373 citedByCount "53" @default.
• W2885069373 countsByYear W28850693732019 @default.
• W2885069373 countsByYear W28850693732020 @default.
• W2885069373 countsByYear W28850693732021 @default.
• W2885069373 countsByYear W28850693732022 @default.
• W2885069373 countsByYear W28850693732023 @default.
• W2885069373 crossrefType "journal-article" @default.
• W2885069373 hasAuthorship W2885069373A5020423857 @default.
• W2885069373 hasAuthorship W2885069373A5025016732 @default.
• W2885069373 hasAuthorship W2885069373A5030657851 @default.
• W2885069373 hasAuthorship W2885069373A5032966324 @default.
• W2885069373 hasAuthorship W2885069373A5033091196 @default.
• W2885069373 hasAuthorship W2885069373A5047844519 @default.
• W2885069373 hasAuthorship W2885069373A5053059331 @default.
• W2885069373 hasAuthorship W2885069373A5059648067 @default.
• W2885069373 hasAuthorship W2885069373A5065258137 @default.
• W2885069373 hasAuthorship W2885069373A5070467399 @default.
• W2885069373 hasAuthorship W2885069373A5080306320 @default.
• W2885069373 hasAuthorship W2885069373A5084010479 @default.
• W2885069373 hasAuthorship W2885069373A5084583476 @default.
• W2885069373 hasAuthorship W2885069373A5088794645 @default.
• W2885069373 hasBestOaLocation W28850693731 @default.

• next