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- W2885079428 abstract "Significance Smyd1 is a muscle-specific histone methyltransferase, and its role in the regulation of growth and differentiation in skeletal and cardiac muscle is well established. However, despite the persistent expression of Smyd1 in postnatal cardiomyocytes, the role of Smyd1 in the adult heart is largely unknown. We show that Smyd1 regulates energy metabolism in the heart. Cardiac-specific ablation of Smyd1 in the mouse adult heart resulted in global downregulation of mitochondrial proteins involved in oxidative phosphorylation, concurrent with reduced mitochondrial respiration capacity. We further demonstrate that the regulation of Smyd1 in metabolism is through transcriptional control of PGC-1α, a key regulator of mitochondrial energetics. Thus, our data reveal a role for Smyd1 as a master regulator of cardiac energetics." @default.
- W2885079428 created "2018-08-22" @default.
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- W2885079428 date "2018-07-30" @default.
- W2885079428 modified "2023-10-11" @default.
- W2885079428 title "Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart" @default.
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- W2885079428 doi "https://doi.org/10.1073/pnas.1800680115" @default.
- W2885079428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6099878" @default.
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